論文與著作
Papers and Publications
期刊 Journal
L.-C. Hsieh, Z. T. Soh, W.-A. Tsai, T.-F. Chen, H.-H. Lin and J.-S. Lin (2024) Enhancement of stress response in Chinese cabbage through eugenol and clove essential oil. Current Plant Biology 37, 100324 download
Y.-C. Chang, Y.-C. Chiu, N.-W. Tsao, Y.-L. Chou, C.-M. Tan, Y.-H. Chiang, P.-C. Liao, Y.-C. Lee, L.-C. Hsieh, S.-Y. Wang and J.-Y. Yang (2021) Elucidation of the core betalain biosynthesis pathway in Amaranthus tricolor. Scientific Reports 11, 6086 download
Y.-W. Chu, K.-P. Chang, C.-W. Chen, Y.-T. Liang, Z. T. Soh and L.-C. Hsieh* (2020) miRgo: integrating various off-the-shelf tools for identification of microRNA–target interactions by heterogeneous features and a novel evaluation indicator. Scientific Reports 10, 1466. (*corresponding author) download
W.-Y. Lin, Y.-Y. Lin, S.-F. Chiang, C. Syu, L.-C. Hsieh* and T.-J. Chiou* (2018) Evolution of microRNA827 targeting in the plant kingdom. New Phytologist. 217 (4):1712-1725 (*co-corresponding author) download
Y.-W. Chen, R. Satange, P.-C. Wu, C.-R. Jhan, C.-K. Chang, K.-R. Chung, M. J. Waring, S.-W. Lin, L.-C. Hsieh* and M.-H. Hou* (2018) CoII(Chromomycin)2 complex induces a conformational change of CCG repeats from i-motif to base-extruded DNA duplex. Int. J. Mol. Sci. 19 (9), 2796 (*co-corresponding author) download
T.-Y. Huang, C.-K. Chang, Y.-F. Kao, C.-H. Chin, C.-W. Ni, H.-Y. Hsu, N.-J. Hu, L.-C. Hsieh, S.-H. Chou, I.-R. Lee, and M.-H. Hou (2017) Parity-dependent hairpin configurations of repetitive DNA sequence promote slippage associated with DNA expansion. Proc. Natl. Acad. Sci. U.S.A.114 (36): 9535-9540 download
C. M. Tan, C.-H. Li, N.-W. Tsao, L.-W. Su, Y.-T. Lu, S. H. Chang, Y. Y. Lin, J.-C. Liou, L.-C. Hsieh, J.-Z. Yu, C.-R. Sheue, S.-Y. Wang, C.-F. Lee and J.-Y. Yang (2016) Phytoplasma SAP11 alters 3-isobutyl-2-methoxypyrazine biosynthesis in Nicotiana benthamiana by suppressing NbOMT1. J Exp. Bot. 67 (14): 4415-4425 download
L.-C. Hsieh, C.-Y. Tseng, L. Luo, F. Ji and H.-C. Lee (2015) Evolutionary Tree Based on Oligonucleotide Frequencies and Conserved Words in 16S and 18S Ribosomal RNA. Biomed Sci. Today 2:e11-1-13. download
L.-C. Hsieh, C.-Y. Tseng, L. Luo, F. Ji and H.-C. Lee (2015) Oligo-distance: A Sequence Distance Determined by Word Frequencies. Biomedical Science Today 1:e5-1-8. download
B. Schaefke, J.J. Emerson, T.-Y. Wang, M.-Y. Lu, L.-C. Hsieh, W.-H. Li. (2013) Inheritance of gene expression level and selective constraints on trans- and cis-regulatory changes in yeast. Mol. Biol. Evol. 30: 2121-2133. download
J.J. Emerson*, L.-C. Hsieh*, H.-M. Sung*, T.-Y. Wang*, C.-J. Huang, H.-H. Lu, M.-Y. Lu, S.-H. Wu, and W.-H. Li. (2010) Natural selection on cis and trans regulation in yeasts. Genome Research 20: 826-836. (*contributed equally) download
L.-C. Hsieh*, S.-I Lin*, H.-F. Kuo and T.-J. Chiou. (2010) Abundance of tRNA-derived small RNAs in phosphate-starved Arabidopsis roots. Plant Signaling and Behavior 5:5, 1-3. (*contributed equally) download
L.-C. Hsieh*, S.-I Lin*, A. C. Shih, J.-W. Chen, W.-Y. Lin, C.-Y. Tseng, W.-H. Li and T.-J. Chiou. (2009) Uncovering small RNA-mediated responses to phosphate-deficiency in Arabidopsis by deep sequencing. Plant Physiol. 151: 2120-2132. (*contributed equally) download
Y.-C. Lin*, L.-C. Hsieh*, M.-W. Kuo, J. Yu, H.-H. Kuo, W.-L. Lo, R.-J. Lin, A. L. Yu and W.-H. Li (2007) Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. Mol. Biol. Evol. 24: 2525-2534. (*contributed equally) download
H.-D. Chen, C.-H. Chang, L.-C. Hsieh and H.-C. Lee (2005) Divergence and Shannon information in genomes. Phys. Rev. Lett. 94: 178103. download
C.-H. Chang, L.-C. Hsieh, T.-Y. Chen, H.-D. Chen, L. Luo and H.-C. Lee (2005) Shannon information in complete genomes. J. Bioinfo. Comp. Biology 3: 587-608. download
T.-Y. Chen, L.-C. Hsieh and H.-C. Lee (2005) Shannon Information and Self-similarity in whole genomes. Computer Physics Communications 169 218-221. download
T.-Y. Chen, L.-C. Hsieh, C.-H. Chang, L. Luo, F. Ji and H.-C. Lee (2004) Universal lengths in complete microbial genomes. Int. J. Mod. Phys. B 18: 2448-2454. download
L.-C. Hsieh, L. Luo, F. Ji and H.-C. Lee (2003) Minimal model for genome evolution and growth. Phys. Rev. Lett. 90: 018101-018104. download
L.-C. Hsieh, H.-C. Lee (2002) Model for the growth of bacterial genomes. Mod. Phys. Lett. B 16: 821-827. download
國內、外研討會 Seminar
C.-H. Yang, K.-L. Huang, F.-R. Liu, Y.-J. Chen, H.-W. Li, Y. Lin and L.-C. Hsieh (2023) An Integrated Image-Based Database for Phalaenopsis Orchids: A Resource for Phalaenopsis Breeding Using Images and Genetic Relationships. 17th International Symposium on Biocatalysis and Agricultural Biotechnology (17th ISBAB). Taichung, Taiwan. November 8-10 (Invited Lecture)
C.-H. Chen and L.-C. Hsieh (2023) A cross-species promoter prediction model based on the inception module. 2023 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2023). Hsinchu, Taiwan. June 29-30
M.-H. Li, W.-L. Fan, J.-L. Huang, C.-Y. Wu and L.-C. Hsieh (2023) Identification of Novel Biogenetic Markers in SLE through PRS Model and Rare Variant Analysis. 2023 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2023). Hsinchu, Taiwan. June 29-30
Hsing-Fun Hsu, Fa-Ren Liu, K.-L. Huang, C.-H. Yang and L.-C. Hsieh (2022) Identification of orchid miRNA-target pairs using Degradome-Seq and sRNA-Seq technologies. 16th International Symposium on Biocatalysis and Agricultural Biotechnology (16th ISBAB). Taichung, Taiwan. November 9-11 (Invited Lecture)
K.-L. Huang, C-L. Ma, C.-H. Yang and L.-C. Hsieh (2022) The differentially expressed genes and the regulation of miRNAs during the development of perianth organs in Phalaenopsis. 16th International Symposium on Biocatalysis and Agricultural Biotechnology (16th ISBAB). Taichung, Taiwan. November 9-11
M.-H. Li, W.-L. Fan, P.-C. Lu and L.-C. Hsieh (2022) Utilizing genome-wide association analysis and machine learning techniques to predict genetic biomarkers in patients with systemic lupus erythematosus from next-generation sequencing. 2022 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2022). Taipei, Taiwan. March 12-13
K.-L. Huang, F.-R. Liu, C.-H. Yang and L.-C. Hsieh (2021) Identification of differentially expressed microRNAs and their targets during the development of perianth organs in Phalaenopsis. Joint Conference for Agriculture Biotechnology. Nantou, Taiwan. December 10-11
W.-T. Chen, C.-X. Chen, J.-Y. Yang and L.-C. Hsieh (2021) Investigation of the key enzyme CYP76AD1 of the betalain pathway and its transcriptional regulation in Amaranthus tricolor. Joint Conference for Agriculture Biotechnology. Nantou, Taiwan. December 10-11
K.-L. Huang, F.-R. Liu and L.-C. Hsieh (2020) Identification of microRNAs of a moth orchid Phalaenopsis Sogo Yukidian from small RNA sequencing data. 2020 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2020). Taipei, Taiwan. December 5
L.-C. Hsieh, F.-R. Liu and Y.-M. Hsiao (2019) Genome-free detection of plant microRNAs from small RNA sequencing data - a homology-based approach. International Symposium on Advanced Plant Biotechnology. Hanoi, Vietnam. December 5-7 (Invited Lecture)
Z. T. Soh, T.-F. Chen, W.-A. Tsai, L.-C. Hsieh, J.-S. Lin (2019) Effects of natural products on thermoregulatory responses in Brassica rapa. 2019 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2019). Miaoli, Taiwan. November 3-4
S.-J. Huang, L.-C. Hsieh and S.-M. Dai (2019) Transcriptome analysis of permethrin-resistant Aedes aegypti in Taiwan. 2019 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2019). Miaoli, Taiwan. November 3-4
Y.-C. Huang, W.-C. Chao and L.-C. Hsieh (2018) Identification of sepsis pathogens in the plasma by next generation sequencing. International Conference on Computational Biology and Bioinformatics. Tokyo, Japan. September 5-6
Y.-C. Huang, Y.-Z. Huang, T.-H. Lee and L.-C. Hsieh (2017) Investigation of differently expressed genes and related pathways in brain in response to cold stress in Oryzias dancena by de novo assembly and analysis of RNA-Seq data. 2017 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2017). Hualian, Taiwan. November 5-6
H.-T. Yang, Y.-M. Hsiao and L.-C. Hsieh (2016) Identification of microRNA transcription start sites of vertebrates using RNA-seq data and sequence features. 2016 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2016). Kaohsiung, Taiwan. November 24-25
Y.-C. Huang, T.-H. Lee and L.-C. Hsieh (2016) Transcriptome analysis reveals the low-temperature-induced genes and pathways in brains of the brackish medaka, Oryzias dancena. 2016 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2016). Kaohsiung, Taiwan. November 24-25
L.-C. Hsieh and C.-K. Lai (2015) Identification of chimpanzee microRNA transcription start sites and divergence of the regulation of miRNA transcription between human and chimpanzee. 2015 Annual Meeting of Society for Molecular Biology and Evolution (SMBE 2015). Vienna, Austria. June 12-16
H.-H. Chu, C.-K. Lai and L.-C. Hsieh* (2014) Identification of MicroRNA Promoters from CAGE Data and Sequence Features. 2014 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB 2014). Tainan, Taiwan. November 7-8
L.-C. Hsieh (2014) Identification of Promoter regions of intergenic microRNAs from next-generation transcriptome sequencing data. Biology Inspired Theoretical Sciences Congress 2014 (BITS 2014). Taoyuan, Taiwan. June 26-28 (Invited Lecture)
L.-C. Hsieh (2013) Identification of transcription start sites of intergenic microRNAs from high-throughput transcriptome sequencing data. International Symposium on Evolutionary Genomics and Bioinformatics 2013(ISEGB 2013). Taichung, Taiwan. November 8-9 (Invited Lecture)
H.-Y. Fang, Y.-P. Hsu, H.-H. Chu and L.-C. Hsieh* (2013) Using high-throughput sequencing data to predict the transcriptional start sites of mouse microRNAs. Proceedings of the Taiwan Academic Network Conference, pp. 1029 -1034. Taichung, Taiwan. October 23-25
L.-C. Hsieh, Y.-C. Fang, W.-H. Li and A. C. Shih. (2012) Not Genetic Hitchhiking but Positive Selection Plays a Major Role in Influenza A Hemagglutinin Evolution. 2012 Annual Meeting of Society for Molecular Biology and Evolution (SMBE 2012). Dublin, Ireland. June 23-26
T.-Y. Wang, H.-M. Sung, T.-L. Liu, L.-C. Hsieh and W.-H. Li. (2011) Trans vs. Cis Changes in Yeast Gene Expression Evolution. 2011 Annual Meeting of Society for Molecular Biology and Evolution (SMBE 2011). Kyoto, Japan. July 26-30
L.-C. Hsieh, S.-I Lin, C. C. Shih, W.-H. Li and T.-J. Chiou. Uncovering small RNA-mediated responses to stress conditions by deep sequencing-based expression analysis. The 15th Joint Biophysics Conference. Taipei, Taiwan. May 19-21, 2010. (Invited Lecture)
C.-H. Chang, L.-C. Hsieh, T.-Y. Chen, H.-D. Chen, L. Luo and H.-C. Lee. (2004) Shannon information in complete genomes. IEEE Computational Systems Bioinformatics Conference (CSB 04): 20-30.
L. Luo, L.-C. Hsieh, F. Ji, M. Jia, H.-C. Lee. (2003) Search for evolution-related-oligonucleotides and conservative words in rRNA sequences. IEEE Computer Society Bioinformatics Conference (CSB 03): 468-469.
L.-C. Hsieh, L. Luo, H.-C. Lee. (2003) Evidence for growth of microbial genomes by short segmental duplications. IEEE Computer Society Bioinformatics Conference (CSB'03): 474-475.