論文與著作

2023-07

Small intestine submucosa as a growth factor attractor promotes peripheral nerve regeneration by enhancing syndecan-3/glial cell line-derived neurotrophic factor (GDNF) signalling: in vivo study 

Chiung-Hui Liu, Yin-Hung Chu, Yin-Hsiu Chen, Yu-Hsin Chiang, Yu-Hsuan Chen, Chung-Yao Ku, Min-Yen Hsu, Yi-Ju Lee, Mao-Yi Yang, Wen-Chieh Liao 

Biomedical materials

2023-06

CHST11-modified chondroitin 4-sulfate as a potential therapeutic target for glioblastoma.

You-Cheng Lin, Yin-Hung Chu, Wen-Chieh Liao, Chia-Hua Chen, Wen-Chuan Hsiao, Ying-Jui Ho, Meng-Yin Yang, Chiung-Hui Liu

American Journal of Cancer Research 

2023-05

Targeting Chondroitin Sulphate Synthase 1 (Chsy1) Promotes Axon Growth Following Neurorrhaphy by Suppressing Versican Accumulation.   

 Accumulation.

Chiung-Hui Liu , Ying-Jui Ho , Che-Yu Wang , Chao-Chun Hsu , Yin-Hung Chu , Min-Yen Hsu, Shiu-Jau Chen , Wen-Chuan Hsiao and Wen-Chieh Liao

Molecules  

2023-03

Effects of the individual three-dimensional printed craniofacial bones with a quick response code on the skull spatial knowledge of undergraduate medical students  

Mao-Yi Yang, Hsien-Chun Tseng, Chiung-Hui Liu, Shao-Yu Tsai, Jyun-Syong Chen,Yin-Hung Chu, Shao-Ti Li, Jian-Jr Lee, and Wen-Chieh Liao   

Anatomical Sciences Education  

2022-12

Risk of Liver Dysfunction and Non-Alcoholic Fatty Liver Diseases in People with Hidradenitis Suppurativa: A Systematic Review and Meta-Analysis of Real-World Evidences 

Shuo-Yan Gau, Yu-Ping Hsiao, Wen-Chieh Liao, Kevin Sheng-Kai Ma, and Meng-Che Wu 

Frontiers in Immunology 

2022-11

Olfactory Stimulation Successfully Modulates the Neurochemical, Biochemical and Behavioral Phenotypes of the Visceral Pain

Wen-Chieh Liao , Rou-An Yao,Li-You Chen, Ting-Yi Renn, Igor V. Klimenkov, Nikolay P. Sudakov, Fu-Der Mai, Yea-Tzy Chen, and Hung-Ming Chang. Molecules

2022-02

Olfactory Stimulation Successfully Improves Swallowing Function of Aged Rats Through Activating Central Neuronal Networks and Downstream DHPR–RyRmediated Neuromuscular Activities.

Yea-Tzy Chen , Li-You Chen , Ting-Yi Renn , Meng-Shan Cheng , Chi-Te Wang , Igor V Klimenkov , Nikolay P Sudakov , Wen-Chieh Liao , Yea-Jyh Chen , Hung-Ming Chang. The Journals of Gerontology: Series A

2022-01

Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin. Ting-Yi Renn, Chih-Ping Yang, Un-In Wu, Li-You Chen, Fu-Der Mai,Maria A. Tikhonova , Tamara G. Amstislavskaya, Wen-Chieh Liao, Che-Tong Lin, YuChuan Liu , Hung-Ming Chang. Chemical Engineering Journal

2021-12

Targeting chondroitin sulfate reduces invasiveness of glioma cells by suppressing CD44 and integrin β1 expression

Yin-Hung Chu, Wen-Chieh Liao, Ying-Jui Ho, Chih-Hsien Huang, To-Jung Tseng Tseng, Chiung-Hui Liu. Cells

2021-09

Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model

Chiung-Hui Liu, Wen-Chieh Liao, Hsin-Hua Li, Li-Ho Tseng, Wei-Han Wang, Hsin Tung, Pin-Jiun Lin, Hsin-Tung Jao,W en-Yuan Liu, Ching-Sui Hung, Chih-Li Lin, Ying-Jui Ho. Fundamental & Clinical Pharmacology

2021-09

Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin. Ting-Yi Renn, Chih-PingYang, Un-In Wu, Li-You Chen, Fu-Do Mai, Maria A.Tikhonova Tamara G, Amstislavski, Wen-Chieh Liao, Che-Tong Ling, Yu-Chuan Liu, Hung-MingChang. Chemical Engineering Journal

2021-08

Olfactory Stimulation Successfully Improves Swallowing Function of Aged Rats through Activating Central Neuronal Networks and Downstream DHPR-RyR-mediated Neuromuscular Activities

Yea-Tzy Chen, Li-You Chen, Ting-Yi Renn , Meng-Shan Cheng, Chi-Te Wang Igor V Klimenkov, Nikolay P Sudakov, Wen-Chieh Liao, Yea-Jyh Chen, Hung-Ming Chang. The journals of gerontology. Series A, Biological sciences and medical sciences

2021-08

Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin. Chen, Y.T., Chen, L.Y., Renn, T.Y., Cheng, M.S., Wang, C.T., Klimenkov, I.V., Sudakov, N.P., Liao, W.C., Chen, Y.J. and Chang, H.M.* Chemical Engineering Journal

2021-07

Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells.

Kuo-Chen Wei, You-Cheng Lin, Chia-Hua Chen, Yin-Hung Chu, Chiung-Yin Huang, Wen-Chieh Liao*, Chiung-Hui Liu.American journal of cancer research

2021-07

Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1α-Sirt1 Pathway. Min-Yen Hsu,Yai-Ping Hsiao, Yu-Ta Lin,Connie Chen, Chee-Ming Lee, Wen-Chieh Liao, Shang-Chun Tsou, Hui-Wen Lin, and Yuan-Yen Chang. Antioxidants

2021-07

Syndecan-3 contributes to the regulation of the microenvironment at the node of Ranvier following end-to-side neurorrhaphy: sodium image analysis. Chiung-Hui Liu, Yu-Chen Kuo, Che-Wu Wang, Chao-Chun Hsu, Ying-Jui Ho, Yun-Chi Chiang, Fu‑Der Mai, Wei-Jhih Lin, Wen-Chieh Liao.

Histochemistry and Cell Biology.

2021-06

Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioral functions in an epilepsy rat model

Hsin-Hua Li, Pin-Jiun Lin, Wei-Han Wang, Li-Ho Tseng, Hsin Tung, Wen-Yuan Liu, Chih-Li Lin1, Chiung-Hui Liu, Wen-Chieh Liao＊, Ching-Sui Hung＊, Ying-Jui Ho＊ Experimental Physiology

2021-03

CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment

Wen-Chieh Liao, Hung-Rong Yen, Chia-Hua Chen, Yin-Hung Chu, Ying‐Chyi Song, To-Jung Tseng, Chiung-Hui Liu. American Journal of Cancer Research

2021-03

CHPF regulates the aggressive phenotypes of hepatocellular carcinoma cells via the modulation of the decorin and TGF-β pathways

Chiung-Hui Liu , Bo-Rui Wu , Ying-Jui Ho , Yin-Hung Chu , Wei-Cheng Hsu , To-Jung Tseng , Ju-Pi Li,* and Wen-Chieh Liao. cancers

2021-02

Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling Ching Chang, Hung-Kai Liu, Chao-Bin Yeh, Ming-Lin Yang, Wen-Chieh Liao, Chiung-Hui Liu and To-Jung Tseng. International journal of molecular sciences

2021-01

Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin. Ting-Yi Renn, Chih-Ping Yang, Un-In Wu, Li-You Chen,Fu-DerMai, Maria A.TikhonovaeTamara, G.Amstislavskaya, Wen-Chieh Liao, Che-Ton Lin, Yu-Chuan Liu, Hung-Ming Chang. Chemical Engineering Journal

2020-03

Melatonin promotes nerve regeneration following end‑to‑side neurorrhaphy by accelerating cytoskeletal remodeling via the melatonin receptor-dependent pathway. Chiung-Hui Liu, Hung-Ming Chang, Yin-Shuo Yang, Yu-Ta Lin, Ying-Jui Ho, To-Jung Tseng , Chyn-Tair Lan , Shao-Ti, Li, Wen-Chieh Liao*. Neuroscience

2020-02

Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability. Wen-Chieh Liao*, Chih-Kai Liao, To-Jung Tseng, Ying‐Jui Ho, Ying-Ru Chen, Kuan-Hung Lin, Te‐Jen Lai, Chyn-Tair Lan, and Kuo-Chen Wei, Chiung-Hui Liu. Oncogenesis

2019-05

A new avenue for treating neuronal diseases: ceftriaxone, an old antibiotic demonstrating behavioral neuronal effects. 

Chun-Hwei Tai, Michele Bellesi, An-Chih Chen, Chih-Li Lin, Hsin-Hua Li, Pin-Jiun Lin, Wen-Chieh Liao, Ching-Sui Hung, Rainer K. Schwarting, Ying-Jui Ho. Brain Research Bulletin

2019-05

Use of Ceftriaxone in Treating Cognitive and Neuronal Deficits Associated With Dementia With Lewy Bodies

Ying-Jui Ho, Mei-Shiuan Shen, Chun-Hwei Tai, Hsin-Hua Li, Jian-Horng Chen, Wen-Chieh Liao, Pai-Yi Chiu, I-Yen Lee, Chih-Li Lin, Ching-Sui Hung. Frontiers in Neuroscience

2019-01

Phosphorylation of extracellular signal-regulated kinase 1/2 in subepidermal nerve fibers mediates hyperalgesia following diabetic peripheral neuropathy. Chiung-Hui Liu, Chyn-Tair Lana, Li-You Chen, Wen-Chieh Liao, Miau-Hwa Koc,To-Jung Tseng. Neurotoxicology

2018-06

DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling

Wen-Chieh Liao*, Chih-Kai Liao, You-Huan Tsai, To-Jung Tseng, Li-Ching Chuang, Chyn-Tair Lan, Hung-Ming Chang, Chiung-Hui Liu

Plos one

2018-03

Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies. Ying-Jui Ho, Jun-Cheng Weng, Chih-Li Lin, Mei-Shiuan Shen, Hsin-Hua Li, Wen-Chieh Liao, Nu-Man Tsai, Ching-Sui Hung, Te-Jen Lai, and I-Yen Lee. Behavioural Neurology

2018-02

Plasmon-activated water effectively relieves hepatic oxidative damage resulting from chronic sleep deprivation. Hsiao-Chien Chen, Chung-Yi Cheng, Li-You Chen, Chun-Chao Chang, Chih-Ping Yang, Fu-Der Mai, Wen-Chieh Liao, Hung-Ming Chang and Yu-Chuan Liu. RSC Advances

2017-10

Rearrangement of potassium ions and Kv1.1/Kv1.2 potassium channels in regenerating axonsfollowing end-to-end neurorrhaphy: ionic images from TOF-SIMS.

Chiung‑Hui Liu, Hung‑Ming Chang, Tsung-Huan Wu, Li‑You Chen, Yin-Shuo Yang, To‑Jung Tseng, Wen‑Chieh Liao*. Histochemistry and cell biology

2017-09

CHSY1 promotes aggressive phenotypes of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway. Chiung-Hui Liu, To-Jung Tseng, Jui-Feng Chou, Chyn-Tair Lan, Wen-Chieh Liao*. Cancer Letters

2017-09

Melatonin successfully rescues hippocampal bioenergetics and improves cognitive functionfollowing drug intoxication by promoting Nrf2-ARE signaling activity. Li‑You Chen , Ting-Yi Renn , Wen-Chieh Liao, Fu-Der Mai, Ying-Jui Ho, George Hsiao, Ai-Wei Lee, Hung‑Ming Chang. Journal of Pineal Research

2017-06

Ceftriaxone reverses deficits of behavior and neurogenesis in an MPTP induced rat model of Parkinson’s disease dementia. Ming-Hong Hsieh*, Wan-Yun Meng*, Wen-Chieh Liao*, Jun-Cheng Weng, Hsin-Hua Li, Hong-Lin Su, Chih-Li Lin, Ching-Sui Hung, Ying-Jui Ho. Brain Research Bulletin

2016-11

Redistribution of Cav2.1 channels and calcium ions in nerve terminals following end-to-side neurorrhaphy: Ionic imaging analysis by TOF-SIMS. Chiung‑Hui Liu, Hung‑Ming Chang,To‑Jung Tseng, Chyn‑Tair Lan, Li‑You Chen, Su‑Chung Youn, Jian‑Jr Lee , Fu‑Der Mai, Jui‑Feng Chou, Wen‑Chieh Liao*

Histochemistry and Cell Biology

2015-12

Comprehensive Application of Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS) for Ionic Imaging and Bio-energetic Analysis of Club Drug-induced Cognitive Deficiency. Su-Chung Youn, Li-You Chen, Ruei-Jen Chiou, Te-Jen Lai , Wen-Chieh Liao ,Fu-Der Mai , Chun-Tsung Hsu , Hung-Ming Chang

Scientific Reports

2015-04

Ceftriaxone Prevents and Reverses Behavioral and Neuronal Deficits in an MPTP-induced Animal Model of Parkinson's Disease Dementia.

Chao-Yu Hsu, Dr.; Ching-Sui Hung, Ph.D.; Hung-Ming Chang, Ph.D.; Wen-Chieh Liao, Ph.D.; Shih-Chun Ho, MS; Ying-Jui Ho, Ph.D.

Neuropharmacology

2015-04

beta-1,4-galactosyltransferase III suppresses extravillous trophoblast invasion through modifying beta 1-integrin glycosylation. Wen-Chieh Liao*; Chiung-Hui Liu; Chia-Hua Chen; Wen-Ming Hsu; Ying-Yu Liao; Hung-Ming Chang; Chyn-Tair Lan; Min-Chuan Huang; Ming-Kwang Shyu. Placenta

2015-03

Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency

Chen LY, Tiong C, Tsai CH, Liao WC, Yang SF, Youn SC Mai FD,Chang HM. Brain Structure and Function

2014-04

Proliferative Effects of Melatonin on Schwann Cells: Implication for Nerve Regeneration following Peripheral Nerve Injury. Chang HM, Liu CH, Hsu WM, Chen LY, Wang HP, Wu TH, Chen KY, Ho WH, Liao WC. Journal of Pineal Reserch

2013-09

Methylcobalamin facilitates collateral sprouting of donor axons and innervation of recipient muscle in end-to-side neurorrhaphy in rats

Liao WC, Wang YJ, Huang MC, Tseng GF. PLoS ONE

2013-03

Resveratrol Suppresses Calcium-Mediated Microglial Activation and Rescues Hippocampal Neurons of Adult Rats following Acute Bacterial Meningitis.

Sheu JN, Liao WC, Wu UI, Shyu LY, Mai FD, Chen LY, Chen MJ, Youn SC, Chang HM*.

Comparative Immunology, Microbiology & Infectious Disease

2013-01

Neuregulin Facilitates Nerve Regeneration by Speeding Schwann Cell Migration via ErbB2/3-dependent FAK Pathway. Chang HM, Shyu MK, Tseng GF, Liu CH, Chang HS, Lan CT, and Liao WC*. Plos one

2012-12

Expression of GALNT2 in human extravillous trophoblasts and its suppressive role in trophoblast invasion. Liao WC, Chen CH, Liu CH, Huang MJ, Chen CW, Hung JS, Chou CH, Chen CH, Che MI, Chang HM, Lan CT, Huang HC, Tseng GF, Shyu MK, Huang MC. Placenta

2012-06

Sleep Deprivation Impairs Ca2+ Expression in the Hippocampus: Ionic Imaging Analysis for Cognitive Deficiency with TOF-SIMS

Chang HM,Liao WC, Sheu JN, Chang CC,Lan CT and Mai FD.

microscopy and microanalysis

2011-12

MUC1 expression is elevated in severe preeclamptic placentas and suppresses trophoblast cell invasion via β1-integrin signaling

Shyu MK, Chen CW, Lin NY, Liao WC, Chen CC, Lin CJ, Huang HC, Lee JJ, Huang MJ, Tseng GF, Shih JC, Lee CN, Hsieh FJ, and Huang MC.

Journal of Clinical Endocrinology and Metabolism.

2010-12

Methylcobalamin, but not methylprednisolone or pleiotrophin, accelerates the recovery of rat. Liao WC, Chen JR, Wang YJ, Tseng GF.Neuroscience

 2009-10

The efficacy of end-to-end and end-to-side neurorrhaphy of brachial plexus nerves in rat. Liao WC, Chen JR, Wang YJ, Tseng GF.Jounal of anatomy

2008-03

Replantation of total avulsed scalp with microsurgery: experience of eight cases and literature review. Yin JW, Matsuo JM, Hsieh CH, Yeh MC, Liao WC, Jeng SF. J Trauma

 2007-06

Reconstruction of extensive scalp defects with free tissue transfer.

Yin JW, Tsan-Shiun Lin, Liao WC, Jeng SF. The journal of plastic surgical association R.O.C.

2003-01

Upregulation of NMDA receptor and neuronal NADPH-d/NOS expression in the nodose ganglion of acute hypoxic rats.

Chang HM, Liao WC, Lue JH, Wen CY, Shieh JY.

J Chem Neuroanat.

 111-114 科技部計畫:利用硫酸肝素蛋白聚醣的分子特性於修復周邊神經損傷之研 究與治療策略開發

• 110 科技 部 計畫名稱：續前年計畫:神經組織蛋白聚醣於神經再生之應用 與相關生物材料開發

• 109 科技 部 計畫名稱：端側神經吻合術後神經性 syndecan 介導神經再生 的治療作用及應用

• 108 科技 部 計畫名稱：探討神經接合術後調控硫酸軟骨素在神經再生的 分子機轉與治療應用

• 105-108 科技部 計畫名稱：褪黑激素調控側接吻合術後再生軸突細胞骨架重 組之療效與分子機制探討

• 103-105 科技部 計畫名稱：探討周邊神經再生後鈣離子通道調控機制與鈣離 子通道調節劑之應用

• 102 科技部 計畫名稱：褪黑激素應用於促進側枝神經接合再生功效之探 討

• 101 科技部 計畫名稱：神經調節蛋白於側枝神經接合再生之應用