Email : prashant.k@cmrit.ac.in
Orchid ID : http://orcid.org/0000-0002-2420-4169
Google Scholar : https://scholar.google.com/citations?user=lEnDOG8AAAAJ&hl=en
Areas of Interest in Teaching
Applied Chemistry for Smart Systems (1BCHES102/202).
Applied Chemistry for Emerging Electronics and Futuristic Devices (1BCHEE102/202).
Areas of Interest in Research
Synthesis and structural activity relationship of biologically important organic compounds.
Discovery and development of novel drugs for Cancer, Hepataties B Virus and Down Syndrome Diseases.
Reactivation of mutant p53 using low molecular weight compounds and peptides.
Asymmetric synthesis of natural products.
Education:
2008-2014 : Ph.D., Organic Chemistry, Department of Organic Chemistry, Indian Institute of Science, Bangalore, India.
Research Experience:
2021-2022 : Research Associate, Institute for Stem Cell Science and Regenerative Medicine, Bangalore, India
2020-2021 : Research Associate, University of Mysore, Mysuru, India.
2014-2016 : Research Associate, University of Colorado, Boulder, USA.
Teaching Experience:
2026-present : Assistant Professor, Department of Chemistry, CMR Institute of Technology, Bangalore, India
2022-2026 : Assistant Professor, Department of Chemistry, SECAB Institute of Engineering and Technology, Vijayapura, India
2017-2020 : Assistant Professor, Department of Chemistry, S. B. Arts and K.C.P Science College , Vijayapura, India
Research Publications:
Enantiospecific Total synthesis of (─) Bengamide E. Prashant K. Metri, Raphael Schiess and Kavirayani R. Prasad. Chem. Asian J. 2013, 8, 488. (Impact Factor: 4.839).
MPK-09, a Small Molecule Inspired from Bioactive Styryllactone Restores the Wild- Type Function of Mutant p53. Prashant K. Metri, Sarwat Naz, Paturu Kondaiah and Kavirayani R. Prasad. ACS Chem. Biol. 2013, 8, 1429. (Impact Factor: 4.634).
Peptaibols from Tichoderma sp (MSX70741): Isolation, structure elucidation and biological activity. Rivera-Chavez J; Raja HA; Metri P; Xue D; Pearce CJ; Oberlies NH. Planta medica. 2016, 82 (S 01): S1. (Impact Factor: 3.007).
Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: validation of their authenticity via in site chemical analysis. Rivera-Chavez J; Raja HA; Graf TN; Gallagher JM; Metri P; Xue D; Pearce CJ; Oberlies NH. RSC Advances. 2017, 7, 45733. (Impact Factor: 4.036).
Enantiospecific formal total synthesis of (+)-dihydrokawain-5-ol. Prashant K. Metri*. Synthetic Communications. 2020, 50, 1361-1366. (Corresponding author). (Impact factor: 1.937).
Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells. Dukanya, Muthu K. Shanmugam, Shobith Rangappa, Prashant K. Metri, Surender Mohan, Basappaa, Kanchugarakoppal S. Rangappa. Bioorganic Med. Chem Lett. 2020, 30, 127330. (Impact Factor: 2.94).
Anti-proliferative activity and Characterization Data on Oxadiazole Derivatives. Dukanya, Muthu K Shanmugam, Shobith Rangappa, Prashant K Metri, Surender Mohan, Basappa, K. S Rangappa. Data in Brief. 2020, 31, 105979. (Impact Factor: 1.379).
Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer. Vikas H. Malojirao, Swamy S. Girimanchanaika, Muthu K. Shanmugam, Ankith Sherapura, Dukanya, Prashant K. Metri, Vellingiri Vigneshwaran, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Shobith Rangappa, Chakrabhavi Dhananjaya Mohan, Basappa, Bettadathunga T. Prabhakar and Kanchugarakoppal S. Rangappa. Biomedicines. 2020, 8, 368. (Impact Factor: 4.757).
Development of a New Arylamination Reaction Catalyzed by Polymer Bound 1,3- (Bisbenzimidazolyl)Benzene Co (II) Complex and Generation of Bioactive Adamanate Amines. Baburajeev Chumadathil Pookunoth, Shilpa Eshwar Rao,Suresha Nayakanahundi Deveshegowda, Prashant Kashinath Metri, Kashifa Fazl-Ur- Rahman, Ganga Periyasamy, Gayathri Virupaiah, Babu Shubha Priya, Vijay Pandey, Peter E. Lobie, Rangappa Knchugarakoppal Subbegowda, Basappa. Catalysts. 2020, 10(11), 1315. (Impact Factor :4.501).
Development of 1-(4-(substituted)piperazin-1-yl)-2-((2-((4- methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethenone as Poly (ADP-Ribose) polymerase cleavage entity in human breast cancer cells. Suresha Nayakanahundi Deveshegowda*, Prashant K Metri*, Muthu K Shanmugam, Shobith Rangappa, Ananda Swamynayaka, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vijay Pandey, Kwang Seok Ahn, Peter E. Lobie, and Basappa Basappa. Molecules, 2022, 27, 2848. (* contributed equally). (Impact Factor: 4.927).
Development of Novel Indole and Coumarin Derivatives as Antibacterial Agents That Target Histidine Kinase in S. aureus. Lisha K. Poonacha , Rashmi Ramesh , Akshay Ravish , Arunkumar Mohan , Pradeep M. Uppar, Prashant K. Metri, Nanjunda Swamy Shivananju, Santosh L. Gaonkar, Shubha Gopal , Alexey Yu Sukhorukov, Vijay Pandey, Priya Babu Shubha and Basappa Basappa. Appl. Microbiology, 2023, 3, 1214.
Development of Novel Pyridine and Pyrimidine Clubbed Bisindoles as Inhibitors of AKT Pathway.Lisha K. Poonacha+, Prashant K. Metri+, Zhang Xi, Akshay Ravish, Omantheswara Nagaraja, Arun M. Kumar, Sindhu M. Parameshwaraiah, Nanjunda, Swamy Shivananju, Mahendra Madegowda, Peter E. Lobie, Priya Babu Shubha, Vijay Pandey, Basappa Basappa. ChemistrySelect. 2024, 9, 1. (+contributed equally).
Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation. Alec Petersa, Fatima Baninea, Kanon Yasuharaa, Angela Hoffmanc, Basappa, Prashant K. Metri, Lily Gunning, Ava Huffman, Jake VanCampen, Clinton C. Shock, Stephen A. Back, Larry S. Shermana*. Journal Of Biological Chemistry, 2024, 300, 107916. (Impact Factor: 4.0).
Patent:
Indian Provisional Patent (1728\CHE\2013). Title: Compounds for activation of mutant p53 protein and process thereof. Inventors Kavirayani Prasad, Pataru Kondaiah, Prashant Metri, Sarwat Naz.
Projects Underaken during M.Sc.:
Undergone training at Indira Gandhi Centre for Atomic Research Kalpakkam 603102, Tamil Nadu, India from 28/0 5/2007 to 06/06/2007 and carried out the project on "Supercritical Fluid Extraction of Organic compounds”.
Carried out the project on “Separation of Uranium from Thorium using HPLC “under the supervision Dr. N. Sivaraman, scientific officer (G) Fuel chemistry Division, Chemistry Group, Indira Gandhi Centre for Atomic Research KALPAKKAM-603102, Tamil Nadu, India.
Honors and Awards :
8th rank in B. Sc from Karnataka Science College Dharwad, Karnatak University, Dharwad.
Gold medal (1st rank) in M.Sc organic chemistry from Karnatak University, Dharwad Karnataka.
Qualified GATE (Graduate Aptitude Test in Engineering) Exam 2008.
Qualified UGC-NET JRF conducted in 2008.
Prof. U. U. Badiger scholarship for standing highest at the M.Sc (pre) chemistry highest continued to M.Sc final examination of the university held in 2007.
Prof. S. Siddappa Endowment scholarship for standing highest at the M.Sc (pre) chemistry highest continued to M.Sc final examination of the university held in 2007.