「社会脳」が生み出す動物のコミュニケーションとその役割

動物は匂い、視覚、聴覚など様々な感覚能力を駆使して、相手の情報を集めています。そしてそれらの情報を適切に処理する社会認知能力によって、その場面に見合った社会行動や生理反応を示します。動物の社会認知能力にはまだまだ不明なことが多いですが、近年ではげっ歯類でも相手の痛みを感じるといった能力まであることがわかってきています。本研究室ではこのような社会認知を研究することで、動物のコミュニケーションとその意義を明らかにします。

主なテーマは以下の通りです。

・マウスの情動伝染における神経回路の解明

・集団行動におけるオキシトシン神経系の役割解明

・慰め行動におけるオキシトシン神経系の役割解明

・マウスの求愛行動におけるホルモンの役割解明

・自閉症モデルマウスを用いた社会性の解明

・イヌのhuman-like social skillsの遺伝的基盤の解明

・イヌの集団意識と内分泌系の関連解析

Selected publications

ーMiceー

Saito H, Nishizumi H, Suzuki S, Matsumoto H, Ieki N, Abe T, Kiyonari H, Morita M, Yokota H, Hirayama N, Yamazaki T, Kikusui T, Mori K, Sakano H. (2017) Immobility responses are induced by photoactivation of single glomerular species responsive to fox odor TMT. Nature Communications 8:16011.

Inokuchi K, Imamura F, Takeuchi H, Kim R, Okuno H, Nishizumi H, Bito H, Kikusui T, Sakano H. (2017) Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odor-induced attractive social responses. Nature Communications 8:15977.

Okabe S, Tsuneoka Y, Takahashi A, Oyama R, Watarai A, Maeda S, Honda Y, Nagasawa M, Mogi K, Nishimori K, Kuroda M, Koide T, Kikusui T. (2017) Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice. Psychoneuroendocrinology 79: 20-30.

Mogi K, Takakuda A, Tsukamoto C, Oyama R, Okabe S, Koshida N, Nagasawa M, Kikusui T. (2017) Mutual mother-infant recognition in mice: the role of pup ultrasonic vocalizations. Behav. Brain Res. 325(Pt B):138-146.

Asaba A, Mogi K, Kikusui T. (2017) Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity. Horm. and Behav. 94:53-60.

Kikusui T, Ishio Y, Nagasawa M, Mogil J, Mogi K. (2016) Early weaning impairs a social contagion of pain-related stretching behavior in mice. Developmental Psychobiology 58(8):1101-1107

Asaba A, Hattori T, Mogi K, Kikusui T. (2014) Sexual attractiveness of male chemicals and vocalizations in mice. Frontiers in Neuroscience 8: 231.

Asaba A, Okabe S, Nagasawa M, Kato M, Koshida N, Osakada T, Mogi K, Kikusui T. (2014) Developmental social environment imprints female preference for male song in mice. PLoS One 9(2): e87186.

Okabe S, Nagasawa M, Kihara T, Kato M, Harada T, Koshida N, Mogi K, Kikusui T. (2013) Pup odor and ultrasonic vocalizations synergistically stimulate maternal attention in mice. Behav. Neurosci. 127(3): 432-8.

Esposito G, Yoshida S, Ohnishi R, Tsuneoka Y, Rostagno Mdel C, Yokota S, Okabe S, Kamiya K, Hoshino M, Shimizu M, Venuti P, Kikusui T, Kato T, Kuroda KO. (2013) Infant calming responses during maternal carrying in humans and mice. Curr. Biol. 23(9):739-45.

Sugimoto H, Okabe S, Kato M, Koshida N, Shiroishi T, Mogi K, Kikusui T, Koide T. (2011) A role for strain differences in waveforms of ultrasonic vocalizations during male–female interaction. PLoS One 6(7): e22093.

Kikusui T, Nakanishi K, Nakagawa R, Nagasawa M, Mogi K, Okanoya K. (2011) Cross fostering experiments suggest that mice songs are innate. PLoS One 6(3): e17721.

Haga S, Hattori T, Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K. (2010) A male mouse pheromone ESP1 enhances female sexual receptive behavior via a select vomeronasal receptor. Nature 466: 118-122.

Okabe S, Nagasawa M, Kihara T, Kato M, Harada T, Koshida N, Mogi K, Kikusui T. (2010) The Effects of Social Experience and Gonadal Hormones on Retrieving Behavior of Mice and their Responses to Pup Ultrasonic Vocalizations. Zool Sci. (10): 790-5.

Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, Ikeda M, Itohara S, Ikawa M, Okabe M, Kikusui T, Mori K, Sakano H. (2007) Innate versus learned odor processing in the mouse olfactory bulb. Nature 450: 503-508.

ーDogsー

Ohkita M, Nagasawa M, Mogi K, Kikusui T. (2016) Owners' direct gazes increase dogs' attention-getting behaviors. Behav. Processes 125: 96–100.

Katayama M, Kubo T, Mogi K, Ikeda K, Nagasawa M, Kikusui T. (2016) Heart rate variability predicts the emotional state in dogs. Behav. Processes 128: 108–112.

Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T. (2015) Oxytocin-gaze positive loop and the coevolution of human-dog bonds. Science 348(6232):333-6.

Tonoike A, Nagasawa M, Mogi K, Serpell J, Ohtsuki H, Kikusui T. (2015) Comparison of owner-reported behavioral characteristics among genetically clustered breeds of dog (Canis familiaris). Scientific Rep. 5: 17710.

Saito A, Hamada H, Kikusui T, Mogi K, Nagasawa M, Mitsui S, Higuchi T, Hasegawa T, Hiraki K. (2014) Urinary oxytocin positively correlates with performance in facial visual search in unmarried males, without specific reaction to infant face. Frontiers in Neuroscience 8: 217.

Romero T, Nagasawa M, Mogi K, Hasegawa T, Kikusui T. (2014) Oxytocin promotes social bonding in dogs. Proc. Natl. Acad. Sci. U S A. 111(25):9085-90.

Nagasawa M, Kawai E, Mogi K, Kikusui T. (2013) Dogs show left facial lateralization upon reunion with their owners. Behav. Processes 98:112-6.

Nagasawa M, Mogi K, Kikusui T (2012) Continued Distress among Abandoned Dogs in Fukushima. Scientific Reports 2: 724.

Mitsui S, Yamamoto M, Nagasawa M, Mogi K, Kikusui T, Ohtani N, Ohta M. (2011) Urinary oxytocin as a noninvasive biomarker of positive emotion in dogs. Horm Behav. 60(3):239-43.

Nagasawa M, Murai K, Mogi K, Kikusui T. (2011) Dogs can discriminate human smiling faces from blank expressions. Anim. Cogn.14(4): 525-33.

Nagasawa M, Mogi K, Kikusui T. (2009) Attachment between humans and dogs. Jpn. Psychol. Res. 51(3):209-221.

Nagasawa M, Kikusui T, Onaka T, Ohta M. (2009) Dog's gaze at its owner increases owner's urinary oxytocin during social interaction. Horm. Behav. 55: 434-441.