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This P50 center supports preclinical research aimed at understanding the molecular, cellular and circuitry mechanisms by which developmental exposure to ethanol influences the maturation of behavioral processes. Our project focuses on determining the potentially dissociable roles of gonadal hormones and sex chromosome complement on the response of embryos to gestational ethanol exposure. It utilizes the Four Core Genotypes mouse model.
This project, conducted in collaboration with Professor Desmond Smith (UCLA Pharmacology) focuses on delineating the heritable patterns of neuroadaptation in gene expression elicited by intravenous cocaine self-administration. It utilizes an advanced population of inbred mice known as the hybrid mouse diversity panel.
This center, a collaboration between The Jackson Laboratory (Bar Harbor ME), University of North Carolina (Chapel Hill), University of Pittsburgh and Binghamton University uses systems genetic approaches to map genomic correlates of addiction-relevant behaviors. Our project focuses on genetic influences on impulsive action and choice. It utilizes the Collaborative Cross and Diversity Outbred mouse models.
This project, a collaboration with Professor Art Arnold (UCLA Integrative Biology and Physiology) delineates the role for sex chromosome complement in Klinefelter Syndrome (47,XXY) related behaviors. It utilizes the Sex Chromosome Trisomy, Four Core Genotypes and XY* mouse models.
This training grant provides support to 4 doctoral students and 2 postdoctoral researchers to facilitate in depth, research-intensive training, as well as professional development activities and education on the responsible conduct of research.
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