~ Welcome to the Wei Lab ~

The Wei Laboratory investigates the molecular principles that build cellular architecture and sustain organismal physiology. Our research centers on the assembly, organization, and functional regulation of microtubules and microtubule-based organelles, particularly centrosomes and cilia. We seek to determine how precise control of these cytoskeletal structures governs physiological processes, and how their disruption leads to developmental defects and human disease.

To address these questions, we integrate cell biology, advanced imaging, biochemistry, biophysics, multiomics approaches, and mouse genetics. Our work spans three major research areas: centrosome and cilium biology, spermatogenesis, and neurodevelopment, with a strong emphasis on two clinically relevant conditions: male infertility and malformations of cortical development.