Shih-Hwa Chiou

Position

• • Visiting Scholar, Harvard Medical School / Harvard Stem Cell Institute, USA (January 2016 – March 2016)

  • Visiting Scholar, Department of Molecular and Experimental Medicine, The Scripps Research Institute (TSRI), USA (March 2007 – August 2007)

  • Attending Physician, Department of Ophthalmology, Taoyuan Veterans General Hospital (January 2003 – December 2004)

  • Postdoctoral Research Fellow, Laboratory of Hematopoietic Stem Cell Transplantation, Beckman Research Institute, USA (February 2002 – April 2002)

  • Attending Physician, Department of Ophthalmology / Glaucoma Division, Taipei Veterans General Hospital (January 2000 – December 2002)

  • Clinical Research Fellow, Department of Ophthalmology, Taipei Veterans General Hospital (July 1998 – 1999)

  • Resident Physician and Physician, Department of Ophthalmology, Taipei Veterans General Hospital (July 1994 – June 1998)

  • Attending Physician, Department of Medical Research, Taipei Veterans General Hospital (Since December 2013 – Present)

  • Division Chief, Division of Basic Medical Research, Department of Medical Research, Taipei Veterans General Hospital (December 2013 – December 2018)

  • Director, Department of Medical Research, Taipei Veterans General Hospital (Since January 2019 – January 2025)

Education

• Institute of Clinical Medicine, National Yang Yang-Ming University PhD

• School of Medicine, National Defense Medical College 

Expertise

• • Ophthalmology and Retinal Regenerative Medicine

  • Stem Cell Genes and Cellular Reprogramming

  • Gene Editing and Nanoparticle-Mediated Gene Deliver

Selected Publications

1. Towards a holistic framework for multimodal LLM in 3D brain CT radiology report generation. i CY, Chang KJ, Yang CF, Wu HY, Chen W, Bansal H, Chen L, Yang YP, Chen YC, Chen SP, Chen SJ, Lirng JF, Chang KW, Chiou SH*(Corresponding Author).Nat Commun. 2025 Mar 6;16(1):2258. doi: 10.1038/s41467-025-57426-0. (Impact factor=14.7)

2. Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization. Kao-Jung Chang , Hsin-Yu Wu, Pin-Hsuan Chiang, Yu-Tien Hsu , Pei-Yu Weng, Ting-Han Yu , Cheng-Yi Li, Yu-Hsiang Chen, He-Jhen Dai , Han-Ying Tsai , Yu-Jung Chang , You-Ren Wu , Yi-Ping Yang, Cheng-Ta Li , Chih-Chien Hsu, Shih-Jen Chen , Yu-Chun Chen, Ching-Yu Cheng, Ai-Ru Hsieh , Chiou SH*(Corresponding Author). J Adv Res. 2025 Mar:69:197-213.(Impact factor=11.4)

3. Identifying Multiomic Signatures of X-Linked Retinoschisis-Derived Retinal Organoids and Mice Harboring Patient-Specific Mutation Using Spatiotemporal Single-Cell Transcriptomics. Chien Y, Wu YR, Chen CY, Yang YP, Ching LJ, Wang BX, Chang WC, Chiang IH, Su P, Chen SY, Lin WC, Wang IC, Lin TC, Chen SJ, Chiou SH*(Corresponding Author). Adv Sci (Weinh). 2024 Nov 6:e2405818. doi: 10.1002/advs.202405818.(Impact factor=14.3; Ranking= 29/439 (Materials Science, Multidisciplinary); Q1)

4. Neutrophils Recruited by NKX2-1 Suppression via Activation of CXCLs/CXCR2 Axis Promote Lung Adenocarcinoma Progression. La'ah AS, Tsai PH, Yarmishyn AA, Ching LJ, Chen CY, Chien Y, Chen JC, Tsai ML, Chen YC, Ma C, Hsu PK, Luo YH, Chen YM, Chiou GY, Lu KH, Lin WC, Chou YT, Wang ML#, Chiou SH*(Corresponding Author). Adv Sci (Weinh). 2024 Oct;11(38):e2400370. doi: 10.1002/advs.202400370. (Impact factor=14.3; Ranking= 29/439 (Materials Science, Multidisciplinary); Q1)

5. OphthalmicTethered Gold Yarnball-Mediated Retained Drug Delivery for Eye Fundus Disease Treatment. Chou SJ, Yang YP, Chiang MR, Chen CY, Ahmad Mulyadi Lai HI, Lin YY, Wu YR, Wang IC, Yarmishyn AA, Chiou GY, Lin TC, Hwang DK, Chen SJ, Chien Y#, Hu SH#, Chiou SH*(Corresponding Author). Small Science. 2024, 4, 2400095. doi: 10.1002/smsc.202400095. (Impact factor=11.2; Ranking= 43/439 (Materials Science, Multidisciplinary); Q1)

6. Gradient conducting polymer surfaces with netrin-1-conjugation promote axon guidance and neuron transmission of human iPSC-derived retinal ganglion cells. She JW, Young CM, Chou SJ, Wu YR, Lin YT, Huang TY, Shen MY, Chen CY, Yang YP, Chien Y, Ayalew H, Liao WH, Tung YC, Shyue JJ, Chiou SH*(Co-Corresponding Authors), Yu HH#. Biomaterials. 2025 Feb;313:122770. (Impact factor=12.8; Ranking= 4/123 (Materials Science, Multidisciplinary); Q1) 

Biosketch

Professor Chiou has consistently demonstrated exceptional innovation and leadership in both scientific research and its practical applications across multiple disciplines. Under his guidance, the research team at Taipei Veterans General Hospital (TVGH) has achieved remarkable advancements in areas such as stem cell research, cancer therapy, and the treatment of retinal diseases. These accomplishments have garnered international recognition and acclaim.

Among his notable achievements, Professor Chiou led Taiwan’s first clinical trial involving autologous induced pluripotent stem cell (iPSC) transplantation, marking a groundbreaking milestone in the nation's regenerative medicine sector. His leadership has significantly raised the standards of Taiwan’s regenerative medicine industry.

Professor Chiou’s body of research exemplifies the integration of cutting-edge technologies—including nanotechnology, CRISPR gene-editing, and stem cell science. This interdisciplinary approach is poised to further advance cross-university and international collaboration, strengthen Taiwan’s position in biomedical innovation, and accelerate the development of precision medicine. Ultimately, his work offers promising new therapeutic options and renewed hope for patients worldwide.

Beyond his scientific contributions, Professor Chiou has played a pivotal role in shaping Taiwan’s global standing in biomedical research. His dedication to education has also inspired a new generation of researchers and clinicians, many of whom have gone on to achieve distinction in academia and clinical practice.