Bioinformatics and Integrative Genomics Lab
Bioinformatics and Integrative Genomics Lab
Su-Min Yee*, Ji Hye Jeong*, Daeun Kim*, Sung-Bae Kang, Hanna Yoon, Hyein Cho, Daechan Park#, Eunsung Jun#, Mihue Jang#, One-step knock-in CAR constructs in human NK cells enable scalable, TGFβ1-resistant immunotherapy for solid tumors (2026) Theranostics, 16(10):5609-5629, DOI: 10.7150/thno.127565 #co-corresponding *equally contributed
Ye Seop Park*, Chang Beom Jeong*, Minju Kim, Daeun Kim, Daechan Park#, Tae Hyeon Yoo#, Machine learning-assisted engineering of substrate-specific β-lactamases (2026) International Journal of Biological Macromolecules, 358:151692, DOI: 10.1016/j.ijbiomac.2026.151692 #co-corresponding *equally contributed
Jina Seo*, Hyo-Jung Park*, Ayoung Oh*, Chang Beom Jeong, Sohee Kim, Sojeong Lee, Chuna Kim, Hyeshik Chang, Jae-Hwan Nam#, Daechan Park#, 3AIM-seq: Quality assessment of mRNA therapeutics using sequencing for 3' poly(A) tails of in vitro-transcribed mRNA (2025) Molecular Therapy, S1525-0016(25)00484-8, DOI: 10.1016/j.ymthe.2025.06.033
Ye Ji Kim*, Doyeop Oh*, Jaehoon Kim, Jeongtae Son, Jae Yun Moon, Ye Kyung Kim, Bin Ahn, Kyu Ri Kang, Daechan Park#, Hyun Mi Kang#, Heightened incidence of adverse events associated with a live attenuated varicella vaccine strain that lacks critical genetic polymorphisms in ORF62 (2024) Clinical Microbiology and Infection, S1198-743X(24)00417-8, DOI: 10.1016/j.cmi.2024.08.018
Sangyeop Hyun*, Youngmin Han*, Jae Yun Moon*, Young-Ah Suh, Won-Gun Yun, Wooil Kwon, Jong-Eun Lee, Ja-Lok Ku, Jin-Young Jang, Daechan Park#, Defining and tracing subtypes of patient-derived xenograft models in pancreatic ductal adenocarcinoma (2024) Cancer Communications, 44(8):921-925, DOI: 10.1002/cac2.12585
Jae Yun Moon, Jina Seo, Jaewoo Lee#, Daechan Park#, Assessment of attenuation of varicella-zoster virus vaccines based on genomic comparison, (2023) Journal of Medical Virology 95(3), e28590, DOI:10.1002/jmv.28590
Do Young Hyeon*, Dowoon Nam*, Youngmin Han*, Duk Ki Kim*, Gibeom Kim*, Daeun Kim*, Jingi Bae, Seunghoon Back, Dong-Gi Mun, Inamul Hasan Madar, Hangyeore Lee, Su-Jin Kim, Hokeun Kim, Sangyeop Hyun, Chang Rok Kim, Seon Ah Choi, Yong Ryoul Kim, Juhee Jeong, Suwan Jeon, Yeon Woong Choo, Kyung Bun Lee, Wooil Kwon, Seunghyuk Choi, Taewan Goo, Taesung Park, Young-Ah Suh, Hongbeom Kim, Ja-Lok Ku, Min-Sik Kim, Eunok Paek, Daechan Park#, Keehoon Jung#, Sung Hee Baek#, Jin-Young Jang#, Daehee Hwang#, Sang-Won Lee#, Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes, (2023) Nature Cancer 4(2), 290–307,
DOI:10.1038/s43018-022-00479-7
Se Won Park*, Jaehoon Kim*, Sungryong Oh*, Jeongyoon Lee, Joowon Cha, Hyun Sik Lee, Keun Il Kim, Daechan Park#, Sung Hee Baek#, PHF20 is crucial for epigenetic control of starvation-induced autophagy through enhancer activation, Nucleic Acids Research, Volume 50, Issue 14, 12 August 2022, Pages 7856–7872, DOI:10.1093/nar/gkac584
Chuna Kim*, Sanghyun Sung*, Jong-Seo Kim*, Hyunji Lee, Yoonseok Jung, Sanghee Shin, Eunkyeong Kim, Jenny J. Seo, Jun Kim, Daeun Kim, Hiroyuki Niida, Narry V. Kim, Daechan Park# and Junho Lee#, Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells (2021) Nature Communications 12(1):1097. DOI: 10.1038/s41467-021-21341-x