A paper authored by Takeshi Fujii, Yukio Ishikawa, and several collaborators has been published in the online version of Proceedings of the National Academy of the USA on October 18, 2011. http://www.pnas.org/cgi/doi/10.1073/pnas.1107282108
Normal males of silkmoth respond to bombykol, which is secreted by females as the sex pheromone. However, the male moths of spli mutants showed only weak response to bombykol, but strongly responded to bombykal, an oxidized form of bombykol. We found that a transcription factor, Bmacj6, was completely deleted in the spli mutant. Deletion of Bmacj6 was found to cause decrease in the expression of bombykol receptor and induce mistargeting of the neurons in the brain.