Nucleophilic Catalysis

Nucleophilic Catalysis Via Phosphine Conjugate Addition:

"Asymmetric Total Synthesis of the Iridoid -Glucoside (+)-Geniposide via Phosphine Organocatalysis." Jones, R. A.; Krische, M. J. Org. Lett. 2009, 11, 1849.

"Concise Stereocontrolled Formal Synthesis of (±)-Quinine and Total Synthesis of (±)-7-Hydroxyquinine via Merged Morita-Baylis-Hillman-Tsuji-Trost Cyclization." Webber, P.; Krische, M. J. J. Org. Chem. 2008, 73, 9379.

"Phosphine Catalyzed Allylic Substitution of Morita-Baylis-Hillman Acetates: Synthesis of N-Protected  -Aminophosphonic Acid Esters." Park, H.; Cho, C.-W.; Krische, M. J. J. Org. Chem. 2006, 71, 7892.

"Enatioselective Total and Formal Syntheses of Paroxetine (PAXIL) via Phosphine Catalyzed Enone -Arylation Using Arylbismuth (V) Reagents: A Regiochemical Complement to Heck Arylation." Koech, P. K.; Krische, M. J. Tetrahedron 2006, 62, 10594.

"Regio- and Stereoselective Construction of g-Butenolides via Phosphine Catalyzed Substitution of Morita-Baylis-Hillman Acetates: An Organocatalytic Allylic Alkylation" Cho, C.-W.; Krische, M. J. Angew. Chem. Int. Ed. 2004, 43, 6689.

"Phosphine Catalyzed Regiospecific Allylic Amination and Dynamic Kinetic Resolution of Morita-Baylis-Hillman Acetates" Cho, C.-W.; Kong, J. R.; Krische, M. J. Org. Lett. 2004, 6, 1337.

"Nucleophilic Catalysis via Phosphine Conjugate Addition: Vinyl Sulfones as Reacting Partners in Catalytic Cross-Michael Cycloisomerization" Luis, A.-L.; Krische, M. J. Synthesis (Feature Article), 2004, 2579.

"Phosphine Catalyzed a-Arylation of Enones Using Hypervalent Bismuth Reagents: Regiospecific Enolate Arylation via Nucleophilic Catalysis" Koech, P. K.; Krische, M. J. J. Am. Chem. Soc. 2004, 126, 5350.

"Phosphine Mediated Reductive Condensation of g-Acyloxy Butynoates: A Diversity Oriented Strategy for the Construction of Substituted Furans" Wang, J.-C.; Jung, C.-K.; Krische, M. J. J. Am. Chem. Soc. 2004, 126, 4118.

"Intramolecular Organocatalytic [3+2] Dipolar Cycloaddition: Stereospecific Cycloaddition and The Total Synthesis of (±)-Hirsutene" Wang, J.-C.; Krische, M. J. Angew. Chem. Int. Ed.2003, 42, 5855.

"Catalytic Crossed Michael Cycloisomerization of Thioenoates: Total Synthesis of (±)-Ricciocarpin A" Agapiou, K.; Krische, M. J. Org. Lett. 2003, 5, 1737.

"Catalytic Enone Allylation via Concomitant Activation of Latent Nucleophilic and Electrophilic Partners: Merging Organic and Transition Metal Catalysis" Jellerichs, B. G.; Kong, J.-R.; Krische, M. J. J. Am. Chem. Soc. 2003, 125, 7758.

"Catalytic Diastereoselective Synthesis of Diquinanes from Acyclic Precursors" Wang, J.-C.; Ng, S.-S.; Krische, M. J. J. Am. Chem. Soc. 2003, 125, 3682.

"Organocatalytic Michael Cycloisomerization of bis(Enones): The Intramolecular Rauhut-Currier Reaction" Wang, L.-C.; Luiz, A.-L.; Agapiou, K.; Jang, H.-Y.; Krische, M. J. J. Am. Chem. Soc. 2002, 124, 2402.