Sebastian Höethker

Sebastian Hoethker hoethker@utexas.edu

Sebastian was born in Bonn, where he later obtained his PhD under the supervision of Andreas Gansäuer while studying stereocontrolled, radical, intramolecular transfer reactions using low-valent Titanium complexes. He is a recipient of the Manchot Fellowship as well as the Feodor-Lynen Fellowship awarded by the Alexander von Humboldt Foundation that supports early-career researchers. He joined the Krische group in the winter of 2024 and is interested in plugging fundamental knowledge gaps motivated by streamlining natural product synthesis through the use of innovative, novel methodologies.

Sebastian's Publications (prior to Krische group)

1. Schwarz Goncalves Henriques, D., Rojo-Wiechel, E., Klare, S., Mika, R., Höthker, S., Schacht, J. H., Schmickler, S., Gansäuer, A.*(2022): Titanocene(III)-Catalyzed Precision Deuteration of Epoxides. Angew. Chem. Int. Ed., 61, e202114198. https://doi.org/10.1002/anie.202114198

2. Schacht, J. H., Wu, S., Klare, S., Höthker, S., Schmickler, N., Gansäuer, A.* (2022): Polymethylhydrosiloxane (PMHS) as Sustainable Reductant in the Titanocene Catalyzed Epoxide Hydrosilylation. ChemCatChem, 14, e202200852. https://doi.org/10.1002/cctc.202200852

3. Höthker, S., Mika, R., Goli, H., Gansäuer, A.*(2023): Converging Stereodivergent Reactions: Highly Stereoselective Formal anti-Markovnikov Addition of H2O to Mixtures of Olefins. Chem. Eur. J., 29, e202301031. https://doi.org/10.1002/chem.202301031

4. Höthker, S.*, Gansäuer, A.* (2023): Formal Anti-Markovnikov Addition of Water to Olefins by Titanocene-Catalyzed Epoxide Hydrosilylation: From Stoichiometric to Sustainable Catalytic Reactions. Global Challenges, 7, 2200240. https://doi.org/10.1002/gch2.202200240

5. Höthker, S., Plato, A., Grimme, S., Qu, Z.-W.*, Gansäuer, A.* (2024): Stereoconvergent Approach to the Enantioselective Construction of α-Quaternary Alcohols by Radical Epoxide Allylation. Angew. Chem. Int. Ed., 63, e202405911. https://doi.org/10.1002/anie.202405911

6. Höthker, S., Goli, H., Klare, S., Krebs, T., Schacht, J. H., Gansäuer, A.* (2024): Attenuating Nucleophilicity of Titanocene Hydrides beyond Steric Effects en Route to Fatty Alcohols. Chem. Eur. J., 30, e202402694. https://doi.org/10.1002/chem.202402694

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