Eli

ELI ORTIZ eliortiz@utexas.edu

Eli was born in Delicias, Chihuahua, Mexico but spent his formative years in San Antonio, Texas. He graduated with his B.S. in Biochemistry from the University of Texas at San Antonio on June 2019. While there, he worked on the development of a novel reductive amination of indoles in collaboration with Bristol Myers Squibb, and a scalable semisynthetic route of artemisinin precursors under the tutelage of Prof. Doug E. Frantz. In the fall of 2019, he joined the Krische group and is working on methods development.

Eli's Publications

13. “Leveraging the Stereochemical Complexity of Octahedral Diastereomeric-at-Metal Catalysts to Unlock Regio- Diastereo and Enantioselectivity in Alcohol-Mediated C-C Couplings via Hydrogen Transfer,” Shezaf, J. Z.; Santana, C. G.; Ortiz, E.; Meyer, C. C.; Liu, P.; Sakata, K.; Huang. K.-W.; Krische, M. J. J. Am. Chem. Soc. 2024, 146, DOI: 10.1021/jacs.4c01857.

12. “Palladium(I)-Iodide Catalyzed Deoxygenative Heck Reaction of Vinyl Triflates: A Formate-Mediated Cross-Electrophile Reductive Coupling with cine-Substitution,” Chang, Y.-H.; Shen, W.; Shezaf, J. Z.; Ortiz, E.; Krische, M. J. J. Am. Chem. Soc. 2023, 145, DOI: 10.1021/jacs.3c09876.

11. “Intermolecular Metal-Catalyzed C‒C Coupling of Unactivated Alcohols or Aldehydes for Convergent Ketone Construction beyond Premetalated Reagents,” Spinello, B. J.; Ortiz, E.; Evarts, M. M.; Strong, Z. H.; Krische, M. J. ACS Catal. 2023, 13, DOI: 10.1021/acscatal.3c02209.

10. “Ruthenium-Catalyzed C-C Coupling of Terminal Alkynes with Primary Alcohols or Aldehydes: α,β-Acetylenic Ketones (Ynones) via Oxidative Alkynylation,” Ortiz, E.; Evarts, M. M.; Strong, Z. H.; Shezaf, J. Z. Angew. Chem. Int. Ed. 2023, 62, In Press (DOI: 10.1002/anie.202303345).

9. “Carbonyl Allylation and Crotylation: Historical Perspective, Relevance to Polyketide Synthesis, and Evolution of Enantioselective Ruthenium-Catalyzed Hydrogen Auto-Transfer Processes,” Ortiz, E.; Saludares, C.; Wu, J.; Cho, Y.; Santana, C. G.; Krische, M. J Synthesis. 2023, DOI: 10.1055/s-00000084.

8. “Asymmetric Ruthenium-Catalyzed Carbonyl Allylations by Gaseous Allene via Hydrogen Auto-Transfer: 1º vs 2º Alcohol Dehydrogenation for Streamlined Polyketide Construction,” Saludares, C.; Ortiz, E.; Santana, C. G.; Spinello, B. J. ACS Catal. 2023, 13, DOI: 10.1021/acscatal.2c05425.

7. “Ruthenium-Catalyzed Dehydrogenation: Historical Perspective and Survey of Enantioselective for Conversion of Lower Alcohols to Higher Alcohols,” Ortiz, E.; Shen, W.; Shezaf, J. Z.; Krische, M. J. Chem. Sci. 2022, 13, DOI: 10.1039/d2sc05621f.

6. “Stereo- and Site-Selective Crotylation of Alcohol Proelectrophiles via Ruthenium-Catalyzed Hydrogen Auto-Transfer Mediated by Methylallene and Butadiene,” Ortiz, E.; Spinello, B. J.; Cho, Y.; Wu, J.; Krische, M. J. Angew. Chem. Int. Ed. 2022, 61, e202212814.

5. “Enantioselective Metal-Catalyzed Reductive Coupling of Alkynes with Carbonyl Compounds and Imines: Convergent Construction of Allylic Alcohols and Amines” Ortiz, E.; Shezaf, J. Z.; Chang, Y.-H.; Krische, M. J. ACS Catal. 2022, 12, 8164.

4. “Stereo- and Site-Selective Conversion of Primary Alcohols to Allylic Alcohols via Ruthenium-Catalyzed Hydrogen Auto-Transfer Mediated by 2-Butyne,” Ortiz, E.; Chang, Y.-H.; Shezaf, J. Z.; Shen, W.; Krische, M. J. J. Am. Chem. Soc. 2022, 144, 8861.

3. “Understanding Halide Counterion Effects in Enantioselective Ruthenium-Catalyzed Carbonyl (α-Aryl)allylation: Alkynes as Latent Allenes and TFE-Enhanced Turnover in The Conversion of Ethanol to Higher Alcohols via Hydrogen Auto-Transfer,” Ortiz, E.; Shezaf, J. Z.; Chang, Y.-H.; Théo P. Gonçalves, Kuo-Wei Huang, Krische, M. J. J. Am. Chem. Soc. 2021, 143, 16709.

2. "Enantioselective Ruthenium-BINAP-Catalyzed Carbonyl Reductive Coupling of Alkoxyallenes: Convergent Construction of syn-sec,tert-Diols via (Z)-σ-Allylmetal Intermediates,” Xiang, M.; Pfaffinger, D.; Ortiz, E.; Brito, G. A.; Krische, M. J. J. Am. Chem. Soc. 2021, 143, 8849–8854.

1. "Catalytic Reductive Aldol and Mannich Reactions of Enone, Acrylate, and Vinyl Heteroaromatic Pronucleophiles," Meyer, C. C.; Ortiz, E.; Krische, M. J. Chem. Rev. 2020, 120, 3721.

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