Royal Society’s 350th Anniversary Philosophical Transactions B issue, entitled Personal Perspectives
In our article, we describe eight distinctive signatures of natural selection that capture different evolutionary mechanisms and relative time scales and then describe good examples of genes where selection has been demonstrated. We also compare approaches that use available human genome datasets in an independent verification of regions found by different methods or using different populations. Lessons learned from genome wide searches for selection in humans will be applied to identify genome signatures of historic selective pressures in other species with emerging genome sequences. They offer considerable potential for genome annotation in functional, developmental, and evolutionary contexts.