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As a ubiquitous and multifunctional protein, Thioredoxin (Trx) is expressed in all forms of life, executing its function through its anti-oxidativeanti-apoptoticanti-inflammatory, and signal-transuding activities. In addition to Trx, the thioredoxin system comprises truncated Trx (Trx-80), Trx reductaseNADPH, and thioredoxin interacting protein (TXNIP), a natural Trx inhibitor.

Still cardiovascular diseases (CVDs), as dysfunctions of heart and blood vessels, remain the leading cause of morbidity and death worldwide. The majority of CVDs result from complications of atherosclerosis. Available evidence supports the notion of central role of oxidative stressinflammation, and aging in the initiation and progression of atherosclerosis. Therefore, targeting the Trx system represents an interesting therapeutic approach for human diseases. 

  


Mahmood DF et alAntioxidants & redox signaling 2013, 19:1266-303.






Mahmood DF et alAntioxidants & redox signaling 2013, 19:1266-303.



Mahmood DF et alAntioxidants & redox signaling 2013, 19:1266-303.





Department of Biology

School of Science

University of Sulaimani

Tasluja –Street 1- Zone 501

46001-Sulaimania

KRG-Iraq

           dler.darweesh@univsul.edu.iq



Dler Mahmood-PubMed 

http://www.ncbi.nlm.nih.gov/pubmed/?term=Dler+Mahmood

Dler Mahmood-Google Scholar

https://scholar.google.com/citations?user=6ITLoE0AAAAJ&hl=en

Dler Mahmood-Research Gate

Dler Mahmood-Research Gate