Research Groups‎ > ‎

Prof.ssa Desideri and Dott.ssa Fioravanti (CHIM/08)

Head of Laboratory: Desideri Nicoletta and Rossella Fioravanti

Website:

Main research topics:


Synthesis, biological evaluation, SAR studies and mechanism of action elucidation of heterocyclic compounds designed as anti-picornavirus or anti-flaviviridae agents. 

Design, synthesis, biological evaluation and SAR studies of selective h-MAO-B inhibitors structurally related to natural flavonoids. 


National and International Collaborations:


Dr. Roberta Loddo, Dipartimento di Scienze Biomediche, Università degli Studi di Cagliari; 

Prof. Antonio Carta, Dipartimento di Chimica e Farmacia, Università di Sassari; 

Prof. Stefano Alcaro e Prof. F. Ortuso, Dipartimento di Scienze della Salute, Università di Catanzaro “Magna Græcia”; 

Dr. Cinzia Conti Dipartimento di Scienze di Sanità Pubblica, Sezione di Microbiologia, Sapienza Università di Roma 

Dr. Matilde Yáñez, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.


Facilities: 


Laboratory 204, CU019: Buchi Rotavapors, Heidolph magnetic stirrers with temperature sensor, Mettler balance. 

Laboratory 116, CU019: Buchi Rotavapors, Heidolph magnetic stirrers with temperature sensor, Gibertini analytical balance. 


ERC panels:


 LS7-3 


Laboratory Members:


Rossella Fioravanti

Nicoletta Desideri


Publications (2015-2018):


1. Rossella Fioravanti, Nicoletta Desideri, Mariangela Biava, Paolo Droghini, Elena Maria Atzori, Cristina Ibba, Gabriella Collu, Giuseppina Sanna, Ilenia Delogu, Roberta Loddo, N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents. Bioorganic & Medicinal Chemistry Letters 25, (2015) 2401-2404. http://dx.doi.org/10.1016/j.bmcl.2015.04.006 


2. Simone Carradori, Marco Pierini, Sergio Menta, Daniela Secci, Rossella Fioravanti, Roberto Cirilli, 3-(Phenyl-4-oxy)-5-phenyl-4,5-dihydro-(1H)-pyrazole: A fascinatingmolecular framework to study the enantioseparation ability of theamylose (3,5-dimethylphenylcarbamate) chiral stationary phase. PartI. Structure-enantioselectivity relationships; Journal of Chromatography A, 1467 (2016) 221–227 http://dx.doi.org/10.1016/j.chroma.2016.07.034 


3. Nicoletta Desideri, Luca Proietti Monaco, Rossella Fioravanti, Mariangela Biava, Matilde Yanez, Stefano Alcaro, Francesco Ortuso (E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors, European Journal of Medicinal Chemistry 117 (2016) 292- 300; http://dx.doi.org/10.1016/j.ejmech.2016.03.081 


4. A. Carta, I. Briguglio, S. Piras, P. Corona, R. Ibba, E. Laurini, M. Fermeglia, S. Pricl, N. Desideri, E.M. Atzori, P. La Colla, G. Collu, I. Delogu, R. Loddo. A combined in silico/in vitro approach unveils common molecular requirements for efficient BVDV RdRp binding of linear aromatic N-polycyclic systems. Eur. J. Med. Chem. 117 (2016) 321-334. 

DOI: 10.1016/j.ejmech.2016.03.080 


5. Fioravanti, Rossella, Desideri, Nicoletta, Carta, Antonio, Atzori, Elena Maria, Delogu, Ilenia, Collu, Gabriella, Loddo, Roberta. Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation. European Journal of Medicinal Chemistry,141 (2017) 15-25. 

DOI: 10.1016/j.ejmech.2017.09.060 


6. Cinzia Conti, Luca Proietti Monaco, Nicoletta Desideri. 3-Phenylalkyl-2H-chromenes and -chromans as novel rhinovirus infection inhibitors: Bioorganic and Medicinal Chemistry. 25 (2017) 2074-2083. DOI: 10.1016/j.bmc.2017.02.012