Workshop sulla Ricerca 2015

     
            
Il Dipartimento di Chimica e Tecnologie del Farmaco il giorno 21 Settembre 2015 organizza un “Workshop sulla Ricerca”, per permettere di avere un quadro più approfondito sui vari temi di ricerca sviluppati dai 20 gruppi appartenenti al Dipartimento e sul loro stato di avanzamento, al fine di segnalare nuovi argomenti che si intende affrontare, confrontarsi sui risultati conseguiti e sulle linee da intraprendere, indicare collegamenti nazionali e internazionali in atto o in progetto. Il Workshop è aperto alla partecipazione di esponenti del mondo industriale e accademico che potranno essere così informati sulle linee di ricerca dipartimentali permettendo in tal modo il possibile inizio di nuove e fruttuose collaborazioni.

Aula D Plesso Tecce

Programma

9:00 Saluti

Sessione I

9:30-9:45 O-01 Nanostructured based Electrochemical and optical biosensors: characterization and applications
Paolo Bollella, Riccarda Antiochia, Gabriele Favero, Cristina Tortolini, Giovanni Fusco, Gabriella Sanzò, Franco Mazzei

9:45-10:00 O-02 Structural characterization of ionic species from simple molecules tobiomolecule-drug complexes
Barbara Chiavarino, Simonetta Fornarini, Maria Elisa Crestoni

 10:00-10:15 O-03 Traditional and innovative methodologies in food characterization
Luisa Mannina, Stefania Cesa, Donatella Capitani, Noemi Proietti, Anatoly P. Sobolev

10:15-10:30 O-04 Synthesis of artificial receptorsfor molecular recognition and discovery of natural compounds with anticanceractivity
Deborah Quaglio, Simone Berardozzi, Andrea Calcaterra, Ilaria D’Acquarica, Francesca Ghirga, Patrizio Ghirga, Cinzia Ingallina, Valentina Iovine, and Bruno Botta

10:30-11:00 BREAK

11:00-11:15 O-05 Application of virtual screening methodologies to get new drugs
Antonio Coluccia, Giuseppe La Regina, Valeria Famiglini, Sveva Pelliccia, Sara Passacantilli, Romano Silvestri

11:15-11:30 O-06 Reattività e struttura di specie gassose isolate, ioniche e neutre, di interesse fondamentale e multidisciplinare
G. de Petris, P. Giacomello, S. Garzoli, F. Pepi, C. Salvitti, A. Troiani

11:30-11:45 O-07 New ways of envisioning phospholipid vesicles in drug delivery
Stefania Petralito, Patrizia Paolicelli, Francesca Apollonio, Micaela Liberti, Martina Nardoni, Caterina Merla, Rosanna Pinto, Settimio Pacelli, Antonella Di Sotto, Maria Antonietta Casadei

 11:45-12:00 O-08 Enantioselective supramolecular devices in the gas phase
Caterina Fraschetti, Laura Guarcini, Maurizio Speranza, Antonello Filippi

 12:00-12:15 O-09 Vesicular nanocarriers: a versatile approach to nanomedicine
C. Marianecci, F. Rinaldi, Patrizia N. Hanieh, M. Carafa

 12:15-12:30 O-10 Small-molecule modulators for epigenetic targets: a new frontier for drug discovery
Antonello Mai, Dante Rotili, Sergio Valente, Clemens Zwergel, Alessia Lenoci, Alessia Lucidi, Mariantonietta Forgione, Biagina Marrocco, Veronica Rodriguez, Giulia Stazi.

 12:30-12:45 O-11 Polysaccharide hydrogels. A versatile tool for biomedical and pharmaceutical applications
Chiara Di Meo, Claudia Cencetti, Elita Montanari, Giuliana Manzi, Tommasina Coviello, Pietro Matricardi

 BREAK

 Sessione II

14:15-14:30 O-12 Compounds influencing endocannabinoid and TRP channels signalling
Enrico Morera, Marianna Nalli, Giorgio Ortar, and Ludovica Monti

14:30-14:45 O-13 Inhibiting the HIVIntegration Process
Valentina Noemi Madia, Luca Pescatori, Giuliana Cuzzucoli Crucitti, Francesco Saccoliti, Antonella Messore, Giovanni Pupo, Francesco Saverio Di Leva, Sandro Cosconati, Ettore,Novellino, Frederic Subra, Olivier Delelis, Giuseppe Rigogliuso, Francesca Esposito, Angela Corona,e Enzo Tramontano, Roberta Costi, and Roberto Di Santo

14:45-15:00 O-14 Chemoinformatics in drug discovery: different fields of application and future perspectives.
Adele Pirolli, Mijat Bozovic, Manuela Sabatino and Rino Ragno

 15:00-15:15 O-15 Anti-Candida albicans biofilm effect of cinnamic and caffeic acid derivatives
Daniela De Vita, Silvano Tortorella, Fabiana Pandolfi, Giovanna Simonetti, Felicia Diodata D’Auria, and Luigi Scipione

15:15-15:30 O-16 5-Membered nitrogen heterocycles and their biological activities
Giovanna Poce, Sara Consalvi Lluis Ballell, Robert H. Bates, Raquel Fernandez-Menendez, Alessandro De Logu, Eric J. Rubin, Lidia Sautebin, Concettina La Motta, Carla Ghelardini, Paola Patrignani, Antonio Giordani, Rino Ragno, Vincenzo Calderone, Maurizio Anzini and Mariangela Biava

15:30-16:00 BREAK

16:00-16:15 O-17 Recent advances in organometallic chemistry: transition-metal catalyzed heterocycles synthesis
Sandro Cacchi, Giancarlo Fabrizi, Antonella Goggiamani, Antonia Iazzetti and Rosanna Verdiglione

 16:15-16:30 O-18 Development and application of modern HPLC/UHPLC and LC-MS techniques, studies of supramolecular host-guest interaction, stereochemical and stereodynamic investigation of chiral molecules.
Sergio Menta, Giuseppe Pierri, Rocchina Sabia, Omar H. Ismail, Alessia Ciogli, Marco Pierini, Claudio Villani, Francesco Gasparrini.

16:30-16:45 O-19 Non-classical and selective carbonic anhydrase inhibitors
Daniela Secci



SESSIONE POSTER

            P1        [abstract]          [poster]
SPR biosensor for the investigation of liposome and anabolic androgenic steroids interactions
Paolo Bollella, Riccarda Antiochia, Gabriele Favero, Cristina Tortolini, Marta Letizia Antonelli, Franco Mazzei

            P2        [abstract]          [poster]
Synthesis and characterization of “green” metallic NPs to develop an electrochemical biosensor
Paolo Bollella, Riccarda Antiochia, Gabriele Favero, Franco Mazzei, Lo Gorton

            P3        [abstract]          [poster]
Nanostructured sensors and biosensors with enhanced electrochemical performance based on Pt Nanoflowers and Pt Nanospheres.
Gabriella Sanzo’, Irene Taurino, Sandro Carrara, Gabriele Favero, Franco Mazzei

            P4        [abstract]          [poster]
Inhibition based electrochemical biosensors for herbicides analysis
Cristina Tortolini, Paolo Bollella, Gabriella Sanzò, Giovanni Fusco, Riccarda Antiochia, Gabriele Favero, Franco Mazzei

            P5        [abstract]          [poster]
Nanostructured modified electrodes for the direct detection of Chemically Oxygen Demand
Giovanni Fusco, Gabriella Sanzò, Andrea D’Annibale, Antonella De Mico, Franco Mazzei

            P6        [abstract]          [poster]
Reactivity and spectroscopy of species involved in NO binding and delivery
Barbara Chiavarino, Simonetta Fornarini, Maria Elisa Crestoni

            P7        [abstract]          [poster]
High-valent metal-oxo complexes: key intermediates in biomimetic oxidations (mimicking Compound I)
Maria Elisa Crestoni, Simonetta Fornarini

            P8        [abstract]          [poster]
Vibrational spectroscopy as structural probe for charged arene adducts: structural, reactivity and spectroscopic features of ion-π interactions
Barbara Chiavarino, Simonetta Fornarini, Maria Elisa Crestoni

            P9        [abstract]          [poster]
Characterization of platinum (II) complexes relevant in antitumor activity
B. Chiavarino, Davide Corinti, M. E. Crestoni, S. Fornarini, J.-Y. Salpin

            P10      [abstract]          [poster]
Probing biomolecules of nutritional interest: structural characterization of ionized pantothenic acid and antocyanins
Davide Corinti, Luisa Mannina, Barbara Chiavarino, Simonetta Fornarini, Maria Elisa Crestoni

            P11      [abstract]          [poster]
Pomegranate fruit  (Punica granatum L.): a functional food
Stefania Cesa, Andrea Coccia, Valeria Giaffreda, Eugenio Lendaro, Alessandra Masci, Luciana Mosca, Federico Pepi, Patrizia Paolicelli

            P12      [abstract]          [poster]
Application of NMR metabolomics to the study of fruits
Luisa Mannina, Stefania Cesa, Donatella Capitani, Noemi Proietti, Anatoly P. Sobolev, Alberta Tomassini, Alfredo Miccheli, Maria E. Di Cocco, Giorgio Capuani, Fabio Sciubba, Flavio R. De Salvador, Maorizio Delfini

            P13      [abstract]          [poster]
Conventional HPLC-DAD methods and colorimetric analysis (CIELab) for the evaluation of blueberry fruits
Stefania Cesa, Federica Lippi, Luisa Mannina, Patrizia Paolicelli

            P14      [abstract]          [poster]
1H NMR Study of Saffron Samples of Different Origin
Luisa Mannina, Silvia Vista Anatoly P. Sobolev, Simone Carradori, Donatella Capitani, , Agata Trella, Federico Marini

            P15      [abstract]          [poster]
Synthesis and NMR investigation of N-peptidoresorc[4]arenes as noncompetitive inhibitors for α-chymotrypsin
Andrea Calcaterra, Ilaria D’Acquarica, Cinzia Ingallinaa, Valentina Iovine, Gloria Uccello-Barretta, and Bruno Botta

            P16      [abstract]          [poster]
Synthesis of a basket-resorc[4]arene via metathesis reaction and encapsulation studies of fullerenes C60 and C70
Ilaria D’Acquarica, Francesca Ghirga, Valentina Iovine, Deborah Quaglio, Sergio Menta, Marco Pierini, and Bruno Botta

            P17      [abstract]          [poster]
Synthesis of chalcones as inhibitors of the Notch signaling pathway in the treatment of T-cell acute lymphoblastic leukemia
Francesca Ghirga, Andrea Calcaterra, Simone Berardozzia, Patrizio Ghirga, Mattia Mori, and Bruno Botta

            P18      [abstract]          [poster]
Gli1/DNA interaction is a druggable target forHedgehog-dependent tumors
Cinzia Ingallina, Simone Berardozzi, Patrizio Ghirga, Mattia Mori, Lucia Di Marcotullio, Gloria Uccello-Barretta, and Bruno Botta

            P19      [abstract]          [poster]
Drug design, synthesis and biological evaluation of new antiretroviral agents
Valeria Famiglini, Giuseppe La Regina, Antonio Coluccia, Andrea Brancale, José A. Esté, Romano Silvestri

            P20      [abstract]          [poster]
Microwave-assisted synthesis of arylthioindoles and aroylindoles as potent inhibitors of tubulin polymerization
Giuseppe La Regina, Valeria Famiglini, Sveva Pelliccia, Sara Passacantilli, Matteo Creta, and Romano Silvestri

            P21      [abstract]          [poster]
Design and Synthesis of New Potent Tubulin Polymerization Inhibitors
Sara Passacantilli, Giuseppe La Regina, Antonio Coluccia, Matteo Creta, Ernest Hamel, Ettore Novellino, Romano Silvestri

            P22      [abstract]          [poster]
New inhibitors of hepatitis C virus targeting cyclooxygenase-2
Sveva Pelliccia, Giuseppe La Regina, Dinesh Manvar , Neerja Kaushik- Basu, Johan Neyt, and Romano Silvestri

            P23      [abstract]          [poster]
Innovative gellan gum and gelatin hydrogels for drug delivery and tissue engineering applications
Settimio Pacelli, Patrizia Paolicelli, Stefania Petralito, Marta Dionisi, Pierluigi Iovino, Felice Cerreto, Arghya Paul, Maria Antonietta Casadei

            P24      [abstract]          [poster]
Gellan gum methacrylate and laponite as innovative nanocomposite hydrogel for biomedical application
Settimio Pacelli, Patrizia Paolicelli, Giuseppe Moretti, Stefania Petralito, Felice Cerreto, Silvia Di Giacomo, Annabella Vitalone,Maria Antonietta Casadei

            P25      [abstract]          [poster]
Manufacturing and characterization of polymeric thin films for buccal delivery of drugs
Gabriele Varani, Alessandra Adrover, Claudia Fioramonti, Giulia Carella, Settimio Pacelli, Patrizia Paolicelli, Stefania Petralito, Maria Antonietta Casadei

            P26      [abstract]          [poster]
Carboxymethyl scleroglucan: a smart biocompatible polymer for drug delivery
Patrizia Paolicelli, Settimio Pacelli, Stefania Petralito, Elisa Ogliani, Gabriele Varani, Alessandra Adrover, Maria Antonietta Casadei

            P27      [abstract]          [poster]
Protonated hexaazamacrocycles as selective K+ receptors
Caterina Fraschetti, Antonello Filippi, Maria Elisa Crestoni, Enrico Marcantoni, Marco Glucini, Laura Guarcini, Maria Montagna, Leonardo Guidoni, Maurizio Speranza

            P28      [abstract]          [poster]
Structure and conformation of protonated biotin in the unsolvated state
Caterina Fraschetti, Antonello Filippi, Laura Guarcini, Vincent Steinmetz, Maurizio Speranza

            P29      [abstract]          [poster]
Acoustic and physicochemical characterization of nanobubbles as theranostic agents
Hanieh P. N., Rinaldi F., Marianecci C., Carafa M.

            P30      [abstract]          [poster]
New strategy in niosomal brain drug delivery
Cinzia Ingallina,, Federica Rinaldi, Bruno Botta, Maria Carafa, Carlotta Marianecci

            P31      [abstract]          [poster]
pHLIP-coated niosomes as novel delivery systems for cancer therapy
F. Rinaldi, P. N. Hanieh, M. Pianella, Y. K. Reshetnyak, C. Marianecci, M. Carafa

            P32      [abstract]          [poster]
Preparation and characterization of vesicular nanocarriers: different approaches to brain delivery
Rinaldi F.,Hanieh P.N:,Carafa M.,Marianecci C.

            P33      [abstract]          [poster]
Design, synthesis & biological validation of 3- aryl- 1,2,4 oxadiazoles as highly potent and selective  SIRT2 inhibitors
Mariantonietta Forgione, Dante Rotili, Clemens Steegborn, Lucia Altucci, and Antonello Mai

            P34      [abstract]          [poster]
Tranylcypromine-based pure stereoisomers as inhibitors of Lysine specific demethylase 1: enzyme selectivity and in-cell studies
Biagina Marrocco, Sergio Valente, Veronica Rodriguez, Ciro Mercurio, Paola Vianello, Giuseppe Ciossani, Saverio Minucci, Andrea Mattevi, Mario Varasi and Antonello Mai

            P35      [abstract]          [poster]
Structure-based lead-optimization of quinoline-based agents as selective non-nucleoside DNA Methyltransferase inhibitors
Giulia Stazi, Clemens Zwergel, Sergio Valente, Christina Gros, Paola B. Arimondo, Danila Trisciuoglio, Donatella Del Bufalo, Antonello Mai

            P36      [abstract]          [poster]
Gellan gum nanohydrogel: a multi-drug delivery system for combination therapy
Giorgia D'Arrigo, Chiara Di Meo, Gemma Navarro, Tommasina Coviello, Franco Alhaique, Vladimir Torchilin, Pietro Matricardi

            P37      [abstract]          [poster]
Hyaluronic acid-based nanohydrogels as drug carriers
Chiara Di Meo, Elita Montanari, Giuliana Manzi, Tommasina Coviello, Claudio Passariello, Claudio Villani, Pietro Matricardi

            P38      [abstract]          [poster]
Scleroglucan, a versatile polysaccharide for modified drug delivery systems: preparation and characterization.
Tommasina Coviello, Chiara Di Meo, Pietro Matricardi, Gianfranco Bocchinfuso, Antonio Palleschi, Franco Alhaique

            P39      [abstract]          [poster]
A novel functionalized collagen based biomaterial for tendon regeneration.
Claudia Cencetti, Pietro Matricardi, Tommasina Coviello, Andrea Martinelli, Anna Scotto D’Abusco, Davide Bellini

            P40      [abstract]          [poster]
Polysaccharide semi-IPNs and IPNs for biomedical applications.
Claudia Cencetti, Laura Pescosolido, Giorgia D’Arrigo, Pauline Chiciriccò, Wim Hennink, Tina Vermonden, Pierre Weiss, Catherine Le Visage, Davide Bellini, Joachim Meraner, Anna Scotto D’Abusco Franco Alhaique, Tommasina Coviello, Pietro Matricardi

            P41      [abstract]          [poster]
SAR exploration of natural product ligands of TRP channels
Enrico Morera, Marianna Nalli, Giorgio Ortar, and Ludovica Monti

            P42      [abstract]          [poster]
SAR analysis of phenolic phytochemicals as TRP channel modulators.
Enrico Morera, Marianna Nalli, Giorgio Ortar, and Ludovica Monti

            P43      [abstract]          [poster]
Design, synthesis, and biological evaluation of molecules targeting both fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels
Enrico Morera, Marianna Nalli, Giorgio Ortar, and Ludovica Monti

            P44      [abstract]          [poster]
New potent antiviral derivatives to defeat poliovirus disease
Luca Pescatori, Valentina Noemi Madia, Giuliana Cuzzucoli Crucitti, Giovanni Pupo,  Antonella Messore, Francesco Saccoliti, Lucia Fiore, Eric Rhoden, M.Steven Oberste, Roberta Costi, Roberto Di Santo

            P45      [abstract]          [poster]
Development of Tyrosyl DNA Phosphodiesterase Inhibitors for the Treatment of Lung Cancer
Giuliana Cuzzucoli Crucitti, Luca Pescatori, Antonella Messore, Valentina Noemi Madia, Giovanni Pupo, Francesco Saccoliti, Francesco Saverio Di Leva, Sandro Cosconati, Ettore Novellino, Christophe Marchand, Yves Pommier, Sabrina Taliani, Federico Da Settimo, Roberta Costi, and Roberto Di Santo

            P46      [abstract]          [poster]
Biological Evaluation of Small Molecules as Stabilizers of Tumor Suppressor Pdcd4
Francesco Saccoliti, Luca Pescatori, Giuliana Cuzzucoli Crucitti, Valentina Noemi Madia, Giovanni Pupo, Antonella Messore, Johanna S. Blees, Magdalena M. Bajer, John A. Beutler, Nancy H. Colburn, Tobias Schmid, Roberta Costi, Roberto Di Santo

            P47      [abstract]          [poster]
Inhibition of Leishmania infantum Trypanothione Reductase by Thioethers.
Giovanni Pupo, Luca Pescatori, Giuliana Cuzzucoli Crucitti, Francesco Saccoliti, Valentina Noemi Madia, Antonella Messore, Andrea Ilari, Gianni Colotti, Gabriella Angiulli, Roberta Costi and Roberto Di Santo

            P48      [abstract]          [poster]
LBDD and SBDD virtual screening techniques in the identification of new lead-compounds: ARSA, and KDM1A case studies
Adele Pirolli, Alexandros Patsilinakos, and Rino Ragno

            P49      [abstract]          [poster]
Py_Qsalign, a new methods for semi-automatic molecular alignment to develop 3-D QSAR models.
Manuela Sabatino, Eleonora Menicacci, Nikola Dino Capocchiano and Rino Ragno

            P50      [abstract]          [poster]
Computer-Aided Drug Design: structure-based (SB) and ligand-based (LB) application to different series of molecules
Martina Agostini, Maria Ilaria D’Andrea, Sonia Ginersio and Rino Ragno

            P51      [abstract]          [poster]
Biological activities of essential oils and extracts of a selection of plant species
Mijat Božović and Rino Ragno

            P52      [abstract]          [poster]
The Use of Python Programming Language for the Developing of Ligand- and Structure-Based Tools.
Rino Ragno

            P53      [abstract]          [poster]
A novel class of small compounds with high and selective inhibition activity on Plasmodium falciparum Carbonic Anhydrase: new potential antimalarial agents
Daniela De Vita, Silvano Tortorella, Fabiana Pandolfi, Louis Maes, Claudiu T. Supuran and Luigi Scipione

            P54      [abstract]          [poster]
Imidazole derivatives with high activity against Trypanosoma cruzi
Daniela De Vita, Silvano Tortorella, Fabiana Pandolfi, An Matheeussen, Louis Maes  and Luigi Scipione

            P55      [abstract]          [poster]
2,6-Dichloro-4-aminopyridine derivatives as new acetylcholinesterase inhibitors
Daniela De Vita, Silvano Tortorella, Fabiana Pandolfi, Manuela Bartolini, Vincenza Andrisano and Luigi Scipione

            P56      [abstract]          [poster]
1,5-Diphenylpyrrole derivatives as COX-2 selective  inhibitors
Giovanna Poce, Sara Consalvi, Lidia Sautebin, Concettina La Motta, Carla Ghelardini, Paola Patrignani, Antonio Giordani, Rino Ragno, Maurizio Anzini and Mariangela Biava

            P57      [abstract]          [poster]
Pharmacodynamic hybrids as nitric oxide donors COX-2 selective inhibitors
Giovanna Poce, Sara Consalvi, Lidia Sautebin, Concettina La Motta, Carla Ghelardini, Paola Patrignani, Vincenzo Calderone, Antonio Giordani, Maurizio Anzini and Mariangela Biava

            P58      [abstract]          [poster]
Towards tuberculosis treatment with a new class of MmpL3 inhibitors
Giovanna Poce, Sara Consalvi, Lluis Ballell, Robert H. Bates, Raquel Fernandez-Menendez, Alessandro De Logu, Eric J. Rubin and Mariangela Biava

            P59      [abstract]          [poster]
Recent advances in heterocyclic synthesis via direct C-H bond activation
Sandro Cacchi, Giancarlo Fabrizi, Antonella Goggiamani, Antonia Iazzetti, Rosanna Verdiglione

            P60      [abstract]          [poster]
Copper-catalyzed and palladium/copper cocatalyzed synthesis of free NH 2-(aminomethyl)indoles
Sandro Cacchi, Giancarlo Fabrizi, Antonella Goggiamani, Antonia Iazzetti and Rosanna Verdiglione

            P61      [abstract]          [poster]
Chemical and biological versatility of the thiosemicarbazone skeleton
Secci Daniela, Bolasco Adriana, Bizzarri Bruna, Chimenti Paola, De Monte Celeste, Granese Arianna, Lavagna Silvio Massimo

            P62    [abstract]          [poster]
1-Substituted N-[(3-phenyl-1H-pyrazol-4-yl)methyl]anilinesas new antiviral agents
Nicoletta Desideri, Rossella Fioravanti, Elena Maria Atzori, Cristina Ibba, Ilenia Delogu, Roberta Loddo

             P63    [abstract]          [poster]
Oxygen Atom Transfer Reaction From Oxyhalogenated Anions To Carbon Monoxide

Anna Troiani

             P64    [abstract]          [poster]
Inside the mechanism of the acid-catalyzed D-Fructose dehydration: a mass spectrometric study

Federico Pepi, Andreina Ricci, Stefania Garzoli, Anna Troiani, Chiara Salvitti, Brunella Di Rienzo, Pierluigi Giacomello

              P65    [abstract]          [poster]
Development of novel quinazoline-based DNMT3A selective inhibitors
Alessia Lucidi, Alessia Lenoci, Mariantonietta Forgione, Paola Arimondo,
Marc Diederich, Dante Rotili, Antonello Mai