The goal of our laboratory is to apply the principles of chemical biology and medicinal chemistry to the design of new chemical and cell based therapies by:
• Applying chemical induced dimerization to guide the self-assembly of protein nanorings that can be used for drug delivery, tumor imaging and the targeting of immune and stem cells for tumor targeting or tissue regeneration.
• Designing therapeutic nucleotide prodrugs that can be targeted too and activated by diseased tissues.
Uncovering the natural function of Hint proteins and applying our
knowledge to the design of anticancer, antiviral drugs and new pain
Chemically Self-Assembled Nanostructures
laboratory has developed a method for the engineering and preparation
of chemically self-assembling nanorings (CSANs) that can display
targeting peptides and proteins, such as single chain antibodies (scFvs)
that can be used for drug delivery, imaging and cell surface
Histidine Triad Binding Proteins (HINTs) are conserved from bacteria to human and are considered to be the ancestor of the histidine triad protein (HIT) superfamily. Humans express three HINTs: hHINT1, hHINT2 and hHINT3. Our laboratory has shown that hHINTs act as nucleoside phosphoramidate monoester and acyl-adenylate hydrolases and are therefore the likely intracellular enzymatic activators of nucleoside phosphoramidates.