Sury Research Group

Sury Lab 1

Research Focus

A large fraction of pharmaceutical products are administered as solids. We are interested in the material science of pharmaceutical solids with a specific emphasis on their physical characterization. In drugs and excipients we investigate the polymorphic form, degree of crystallinity, and the nature and extent of interaction with water.

In addition to X-ray powder diffractometry, thermoanalytical, spectroscopic and microscopic techniques are used for this purpose. We are specifically interested in monitoring and quantifying phase transitions at various stages of pharmaceutical processing. While the active ingredient is of predominant concern, there are cases where phase transitions of excipients may be of relevance and importance. The goal is to ensure reproducible and predictable performance of solid dosage forms with minimum batch-to-batch variations.


Recent Publications

  • Investigation of Spatial Heterogeneity of Salt Disproportionation in Tablets by Synchrotron X-ray Diffractometry Koranne S, Govindarajan R, Suryanarayanan R.  Investigation of Spatial Heterogeneity of Salt Disproportionation in Tablets by Synchrotron X-ray Diffractometry. Mol Pharm. 2017 Mar 2. doi: 10.1021/acs.molpharmaceut.6b01052. [Epub ahead of print]. PMID:28195490
    Posted Mar 27, 2017, 1:30 PM by Jody Tracy
  • Effects of Excipient Interactions on the State of the Freeze-Concentrate and Protein Stability Jena S, Horn J, Suryanarayanan R, Friess W, Aksan A. Effects of Excipient Interactions on the State of the Freeze-Concentrate and Protein Stability. Pharm Res. 2017 Feb;34(2):462-478. doi: 10.1007/s11095-016-2078-y.  PMID: 27981449 (2016).
    Posted Mar 27, 2017, 1:32 PM by Jody Tracy
  • Salt Disproportionation in the Solid State: Role of Solubility and Counterion Volatility. Thakral NK, Behme RJ, Aburub A, Peterson JA, Woods TA, Diseroad BA, Suryanarayanan R, Stephenson GA. Salt Disproportionation in the Solid State: Role of Solubility and Counterion Volatility. Mol Pharm. 2016 Nov 2. [Epub ahead of print] PubMed PMID: 27766882.
    Posted Nov 17, 2016, 11:58 AM by Jody Tracy
  • Accelerated Physical Stability Testing of Amorphous Dispersions. Mehta M, Suryanarayanan R. Accelerated Physical Stability Testing of Amorphous Dispersions. Mol Pharm. 2016 Aug 1;13(8):2661-6. doi: 10.1021/acs.molpharmaceut.6b00218. PubMed PMID: 27299377.
    Posted Nov 17, 2016, 11:58 AM by Jody Tracy
  • Mutual Influence of Mannitol and Trehalose on Crystallization Behavior in Frozen Solutions. Jena S, Suryanarayanan R, Aksan A. Mutual Influence of Mannitol and Trehalose on Crystallization Behavior in Frozen Solutions. Pharm Res. 2016 Jun;33(6):1413-25. doi: 10.1007/s11095-016-1883-7. PubMed PMID: 26908047.
    Posted Nov 17, 2016, 11:57 AM by Jody Tracy
  • Molecular mobility in glassy dispersions. Mehta M, McKenna GB, Suryanarayanan R. Molecular mobility in glassy dispersions. J Chem Phys. 2016 May 28;144(20):204506. doi: 10.1063/1.4950768. PubMed PMID: 27250315.
    Posted Nov 17, 2016, 11:57 AM by Jody Tracy
  • Recent advances in the characterization of amorphous pharmaceuticals by X-ray diffractometry. Thakral S, Terban MW, Thakral NK, Suryanarayanan R. Recent advances in the characterization of amorphous pharmaceuticals by X-ray diffractometry. Adv Drug Deliv Rev. 2016 May 1;100:183-93. doi: 10.1016/j.addr.2015.12.013. Review. PubMed PMID: 26712710.
    Posted Nov 17, 2016, 11:55 AM by Jody Tracy
  • Effect of Water on Molecular Mobility and Physical Stability of Amorphous Pharmaceuticals. Mehta M, Kothari K, Ragoonanan V, Suryanarayanan R. Effect of Water on Molecular Mobility and Physical Stability of Amorphous Pharmaceuticals. Mol Pharm. 2016 Apr 4;13(4):1339-46. doi: 10.1021/acs.molpharmaceut.5b00950. PubMed PMID: 26954586.
    Posted Nov 17, 2016, 11:55 AM by Jody Tracy
Showing posts 1 - 8 of 36. View more »

Current Research

  1. Monitor phase transitions during the entire freeze-drying cycle using special instrumentation built in-house. The ultimate goal is the optimization of the freeze-drying cycles of protein pharmaceuticals.

  2. Simultaneous quantification of reactant, product, and intermediate phases of very rapid reactions (time resolution of 40 msec) using high intensity X-rays.

  3. Use of a microdiffractometer to map tablet surfaces and also to characterize specific regions of a powder bed (or of a tablet).

  4. Identify new excipients or modify the physical state of current excipients with the object of expanding their utility in freeze-dried formulations.


Announcements

  • Congratulations Michelle! Michelle recently walked in the Graduate Hooding Ceremony, held at the TCF Bank Stadium. Dr. Raj Suryanarayanan delivered the commencement address. Michelle expects to defend her thesis in August of 2017. Congratulations, Michelle!
    Posted Jun 8, 2017, 11:13 AM by Jody Tracy
  • Pinal Mistry received the PPB Award at AAPS 2015 Pinal Mistry was selected to receive the 2015 Graduate Student Research Award in Physical Pharmacy and Biopharmaceutics section of AAPS for her poster abstract titled Strength of drug-polymer interactions: implications on the molecular mobility, physical stability, and dissolution behavior of amorphous solid dispersions. This award is designed to recognize excellence in graduate education in the fields of physical pharmacy and biopharmaceutics.  Congratulations, Pinal!
    Posted Dec 1, 2016, 5:30 PM by Jody Tracy
  • Michelle Fung received the APQ Award at AAPS 2016 Michelle Fung was selected to receive the 2016 American Association of Pharmaceutical Scientists (AAPS) Graduate Student Research Award in Analysis and Pharmaceutical Quality (APQ) for her poster, “The Use of Small Molecule Excipients for Improving the Physical Stability and Dissolution Performance of Ketoconazole Spray Dried Dispersions.”  Congratulations, Michelle!
    Posted Dec 1, 2016, 5:11 PM by Jody Tracy
  • Pinal Mistry received the APQ and PPB Awards at AAPS 2016 Pinal Mistry is a recipient of the 2016 American Association of Pharmaceutical Scientists (AAPS) Analysis and Pharmaceutical Quality (APQ) Travelship Award for her poster abstract, “Molecular Mobility as a Polymer Selection Tool for Amorphous Solid Dispersions.” She was also selected as a winner of the AAPS Physical Pharmacy and Biopharmaceutics (PPB) Best Manuscript Contest for her manuscript, “Role of the Strength of Drug-Polymer Interactions on the Molecular Mobility and Crystallization Inhibition in Ketoconazole Solid Dispersions.” The paper was published in the September 2015 issue of Molecular Pharmaceutics.  Congratulations, Pinal!
    Posted Dec 1, 2016, 5:12 PM by Jody Tracy
  • Sampada Koranne received the FDD Award at AAPS 2016 Sampada Koranne was selected to receive the 2016 American Association of Pharmaceutical Scientists (AAPS) Graduate Student Research Award in Formulation Design and Development (FDD) for her poster abstract, “Investigation of the Spatial Heterogeneity of Salt Disproportionation in Tablet Formulations.” This award is designed to recognize excellence in graduate education in the formulation design and development areas, including pre-formulation, biopharmaceutics, formulation strategies and technologies, and manufacturing process optimization. She presented her poster at the 2016 AAPS Annual Meeting and Exposition in Denver, Colorado in November 2016.  Congratulations, Sampada!
    Posted Dec 1, 2016, 5:12 PM by Jody Tracy
  • Sampada Koranne received the APQ Award at AAPS 2015 Sampada Koranne received the 2015 Graduate Student Research Award in Analysis and Pharmaceutical Quality section of AAPS for her poster abstract titled, "Salt disproportionation in the solid state: characterization by thermal, spectroscopic, and diffractometric techniques". This award is designed to recognize excellence in graduate education in the fields of pharmaceutics, bioanalytical chemistry, and pharmaceutical analysis. She presented her poster at the 2015 AAPS Annual Meeting.  Congratulations, Sampada!
    Posted Dec 1, 2016, 5:13 PM by Jody Tracy
  • Congratulations, Mehak Mehta! The Sury Lab gathered at Ginger Hop to celebrate Mehak's graduation and to wish her well upon her departure! 
    Posted Jun 8, 2017, 11:24 AM by Jody Tracy
  • Congratulations to 2015 Ralph Shangraw Memorial Award Winner, Dr. Raj Suryanarayanan! The International Pharmaceutical Excipient Council of the Americas  (IPEC) Foundation has awarded the 2015 Ralph Shangraw Memorial Award to Raj Suryanarayanan, Ph.D.  More information about the award can be found at this link.
    Posted Nov 10, 2015, 11:25 AM by Jody Tracy
Showing posts 1 - 8 of 8. View more »