Steffen Pockes

Dr. Steffen Pockes

Visiting Professor, ITDD & Department of Medicinal Chemistry

Visiting Professor, Department of Neurology

Twitter: @SteffenPockes

PhD, Medicinal Chemistry, University of Regensburg, Germany, 2015

Study of Pharmacy, University of Regensburg, Germany, 2011

Expertise: Medicinal Chemistry, Drug Development

Summary

Steffen Pockes is a Visiting Professor from the University of Regensburg (Germany) and works in the field of Medicinal Chemistry. Since 2019, he is collaborating with the groups of Prof. Karen Hsiao Ashe (Department of Neurology, University of Minnesota) and Prof. Michael A. Walters (Institute for Therapeutics Discovery & Development; Department of Medicinal Chemistry, University of Minnesota). From October 2020 to October 2021 he is working in the groups of. Prof. Ashe and Prof. Walters – equipped with a DFG (German Research Foundation) Research Fellowship – to work in the field of Alzheimer’s disease at the N. Bud Grossman Center for Memory Research and Care and the Department of Medicinal Chemistry/ITDD.

Publications

For a full listing see: Google Scholar Bibliography

Selected Publications:

Rosier, N.; Grätz, L.*; Schihada, H.; Möller, J.; Isbilir, A.; Nagl, M.; Seibel, U.; Lohse, M. J.; Pockes, S.* A Versatile Subnanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor. Journal of Medicinal Chemistry 2021, 64 (15), 11695-11708. https://doi.org/10.1021/acs.jmedchem.1c01089.

Tropmann, K.; Bresinsky, M.; Forster, L.; Buschauer, A.; Wittmann, H.J.; Hübner, H.; Gmeiner, P.; Pockes, S.*; Strasser A.* Abolishing Dopamine D2long/D3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H2R Agonists. Journal of Medicinal Chemistry 2021, 64 (12), 8684-8709. https://doi.org/10.1021/acs.jmedchem.1c00692.

Pockes, S.*; Tropmann, K. Histamine H2 Receptor Radioligands: Triumphs and Challenges. Future Medicinal Chemistry 2021, 13 (12), 1073-1081. https://doi.org/10.4155/fmc-2021-0058.

Biselli, S.; Bresinsky, M.; Tropmann, K.; Forster, L.;  Honisch, C.; Buschauer, A.; Bernhardt, G.; Pockes, S.* Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H2R and D3R. European Journal of Medicinal Chemistry 2021, 214, 113190. https://doi.org/10.1016/j.ejmech.2021.113190.

Tropmann, K.; Höring, C.; Plank, N.; Pockes, S.* Discovery of a G Protein-Biased Radioligand for the Histamine H2 Receptor with Reversible Binding Properties. Journal of Medicinal Chemistry 2020, 63 (21), 13090-13102. https://doi.org/10.1021/acs.jmedchem.0c01494.

Grätz, L.; Tropmann, K.; Bresinsky, M.; Müller, C.; Bernhardt, G.; Pockes, S.* NanoBRET Binding Assay for Histamine H2 Receptor Ligands Using Live Recombinant HEK293T Cells. Scientific Reports 2020, 10 (1), 13288. https://doi.org/10.1038/s41598-020-70332-3.