The Sampson Lab uses computational genomics, bioinformatics, and genetic epidemiology to discover novel nephrotic syndrome associated variants and characterize the clinical implications for patients harboring them. We also seek to understand the prevalence, clinical correlates, and molecular mechanisms underlying known genetic forms of nephrotic syndrome.

Check out Nephrotic Syndrome Variant Server (NephVS), our variant browser! This database has variant information from NEPTUNE. Click here to use our NephVS.

NephVS eQTL Browser

Check out our database of cis-eQTLs of the glomerular and tubulointerstitial tissues of the kidney found in 187 participants in the NEPTUNE cohort. You can use a gene symbol, entrezId, or rsid to find a gene or variant of interest or see our list of the most significant eQTLs in glomerulus and tubulointerstitium. Click here to learn more.
GeneVetter is a tool designed to investigate the background prevalence of exonic variation in the Phase 3 1000 Genomes data under user defined filtering criteria. It can also be used for comparing a user specified VCF (Variant Call Format) file to the 1000 Genomes subjects. Click here to learn more about the tool and here to use it.


We hypothesized that genes playing key roles in NS and glomerular diseases are under stronger negative selection compared to an average gene. Thus, we've used publicly available genetics resources and our to create a genome-wide, Gene-level Integrated Metric of negative Selection (GIMS) for each human gene and Transcript-level Integrated Metric of negative Selection (TIMS). To learn more or use the tool click here.

Keep Up-To-Date with Sampson Lab via Twitter!

Recent News

  • Updates: Two new publications and new members! We are very excited about our new publications and some new Lab members!Check out both of our new publications:Transethnic, Genome-Wide Analysis Reveals Immune-Related Risk Alleles and ...
    Posted Jul 27, 2018, 1:46 PM by Michelle McNulty
  • ASN Kidney Week 2017 Five days, two presentations, and two poster sessions later, Sampson Lab has returned from the beautiful city of New Orleans. Thank you for all who came to hear our work ...
    Posted Nov 9, 2017, 8:54 AM by Kalyn Yasutake
  • Sampson Lab Hits ASN Kidney Week 2017 in NOLA The American Society of Nephrology (ASN) Kidney Week 2017 Annual Meeting has accepted 4 abstracts from Sampson Lab projects! Taking place in New Orleans from October 31 to November 5 ...
    Posted Aug 14, 2017, 10:56 AM by Kalyn Yasutake
  • "Nephrotic syndrome genomic discovery in era of Big Data" presentation posted Check our "Selected Publications" page for a modified version of our talk from the 2016 ASN Annual Meeting.
    Posted Aug 14, 2017, 10:55 AM by Kalyn Yasutake
  • Nephrotic Variant Server (NephVS) Beta 0.01 released We are excited to announce the release of NephVS, the Nephrotic Variant Server. The goal NephVS is to create a database composed of aggregated short-read sequencing and array-based ...
    Posted Aug 14, 2017, 10:55 AM by Kalyn Yasutake
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