Pharmacology
Mechanisms of stress transduction at the sympatho-adrenal synapse
Cellular and molecular mechanisms of pathways that maintain genomic stability or influence therapeutic response in cells treated with anti-cancer agents
Cell biology and immunology; head and neck cancer
Altered striatal function: role in obesity and substance abuse/addiction
Neuropharmacology; regulation of dopamine transporter activity after acute and repeated amphetamine
Chemical carcinogenesis: metabolic activation and detoxication of carcinogens, mechanisms of carcinogen-activating enzymes, cytochrome P-450 and biological oxidations and peroxidations
Thrombosis, signal transduction, Pharmacology, Hematology.
Mechanisms of neurotransmitter and hormone secretion; membrane permeability
Signal transduction by steroid/intracellular receptors; hormonal control of gene expression; transcription factor interactions
Cellular and molecular biology of voltage-gated sodium channels
Basic cellular and molecular mechanisms underlying complex neuropsychiatric diseases
Novel therapeutic targets for mental health disorders
Developmental and opioid-related mechanisms contributing to psychiatric diseases, such as depression and substance abuse.
Regulation of the secretion of neurotransmitters and hormones in both central nervous and endocrine systems
Role of cell cycle checkpoints in response of cells to drugs and radiation
Determining the cellular signaling pathways that lead to cardiac and vascular disease and contribute to the many risk factors, particularly intracellular hormonal signaling and signaling in lipid and glucose metabolism
Chemical pharmacology: free radicals, oxidative stress, drug metabolism, regulation of hemoproteins
Pharmacogenetics/genomics and drug metabolism of Breast Cancer Therapies
1. Role of ion channels and fuel metabolism in the production of Ca oscillations and pulsatile insulin secretion in normal as well as diabetic islets of Langerhans
2. Elucidating how mild traumatic brain injury or concussion impacts upon functional synaptic transmission in the cerebral cortex
Interactions between the G proteins and their protein targets at a molecular and structural level with the goal of understanding how these interactions lead to alterations in protein and cellular activities
G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation
Using in vitro and in vivo models to characterize the mechanism of action of strong analgesic drugs such as morphine