09/25 Crespi on autism

Where Darwin Meets Freud: Evolutionary Biology and the Genetics of Autism, Psychosis, and the Social Brain
Bernard Crespi, Professor of Evolutionary Biology, Simon Fraser University, British Columbia
Tuesday Sept 25 at 4 PM in 1755 School of Public Health  Refreshments at 3:45 PM.
This room is in the old (north) SPH building, take hallway to the left.
Abstract:  I integrate evidence from evolutionary biology, human genetics, psychiatry, psychology and neuroscience to  develop and test hypotheses for the causes and manifestations of human mental disorders that centrally  involve social interaction. A primary hypothesis addressed focuses on   autism spectrum and psychotic-affective spectrum disorders as opposite   (diametric) sets of conditions, mediated by under-development versus   over-development of human-specific social brain phenotypes. This   hypothesis is evaluated using data from the literature and from our   recent studies of how schizophrenia and autism risk alleles influence   performance for verbal, visual-spatial, and other salient skills in   non-clinical populations. This approach, and our results, have direct   implications for the origins, maintenance, genetic causes, diagnosis,   and treatment of autism spectrum and psychotic-affective spectrum
Crespi is a University of Michigan graduate who is the most productive and provocative evolutionary geneticist working on mental disorders. His talks at UM will focus on his hypothesis that autism and schizophrenia are flip sides of the same Trivers/Haig coin involving competition between maternal and paternal genomes using imprinting to advance their own representation in future generations. 
Crespi will also give a talk Tuesday 9/25 at Noon in Room 2009 at the Ruthven Mueseum for the EEB lunch seminar: Evolutionary-ecological tradeoffs in human cognition 
If you would like to meet with Professor Crespi, send a note to EHAP@umich.edu.

If you would like to learn more about the lecture series, full information is at http://EvolutionAndMedicine.com
To get on a mailing list for weekly updates on the series, go to http://mcommunity.umich.edu   and add your uniqname to the group "EHAnnouncements".
This lecture series is sponsored by the UM Evolution and Human Adaptation Program, the School of Public Health Department of Epidemiology and MAC-Epid, and the LS&A Department of Ecology and Evolutionary Biology. 

 Recent publications below 


Crespi, B., P. Stead and M. Elliot (2010) Comparative genomics of autism and schizophrenia.  Proceedings of the National Academy of Sciences 107:1736-1741 (PDF-paper) (PDF-SupportingInfo)


Crespi, B. (2010) The origins and evolution of genetic disease risk in modern humans.   Year in Evolutionary Biology (Annals New York Academy of Sciences) 1206:80-109 (PDF)


Crespi, B. (2010) The strategies of the genes: genomic conflicts, attachment theory and development of the social brain.  Chapter in Art Petronis and Jonathon Mill (Editors). Brain, Behavior and Epigenetics (in press) (PDF)


Arbuthnott, D., M. Elliot, M. McPeek and B. Crespi (2010) Diversification of  courtship and genetalic traits in Timema walking-sticks. Journal of Evolutionary Biology 23:1399-1411 (PDF).


Crespi, B. J. (2010) The emergence of human-evolutionary medical genomics.  Evolutionary Applications (in press) (PDF).


Crespi, B. J. (2010) Revisiting Bleuler: the relationship of autism with schizophrenia.  British Journal of Psychiatry 196:496.


Summers, K. and B. Crespi (2010) Xmrks the spot: life-history tradeoffs, sexual selection, and the evolutionary ecology of carcinogenesis.  Molecular Ecology 19:3022-3024. (PDF).


Springer, S. A., B. J. Crespi and W. J. Swanson (2011) Beyond the phenotypic gambit: molecular behavioral ecology and the evolution of genetic architecture.  Molecular Ecology 20:2240-2257.   PDF


Crespi, B. J. (2011) One hundred years of insanity: genomic, psychological and evolutionary models of autism in relation to  schizophrenia.  In: Textbook of Schizophrenia-Spectrum Disorders, edited by M. Ritsner (in press).(PDF)


Crespi, B. (2011) The evolutionary biology of child health. Proceedings of the Royal Society of London B  278: 1441-1449.  PDF


Schwander, T,  Henry, L and Crespi B. (2011) Molecular evidence for ancient asexuality in Timema stick insects. Current Biology 21:1129-1134.  PDF


Frank SA and Crespi BJ. (2011) Pathology from evolutionary conflict, with a theory of X chromosome versus autosome conflict over sexually antagonistic traits PNAS 108: 10886-10893. PDF


Crespi B. (2011) Autism and cancer risk. Autism Res. 2011 4:302-10. PDF


Crespi BJ, Thiselton DL. (2011) Comparative immunogenetics of autism and schizophrenia. Genes Brain Behavior (in press)  PDF


Somjee, U, Ablard K, Crespi B, Schaefer PW, Gries G (2011)  Local mate competition in the solitary parasitoid wasp Ooencyrtus kuvanae. Behavioral Ecology and Sociobiology  65:1071-1077. PDF


Antolin MF, Jenkins KP, Bergstrom CT, Crespi BJ et al.  (2012) Evolution and medicine In undergraduate education: A prescription for all biology students. Evolution 66:1191-2006 (PDF)


Henry L, Schwander T, and Crespi BJ (2012) Deleterious mutation accumulation in asexual Timema stick insects. Molecular Biology and Evolution 29:401-408 (PDF)


Joy JB and Crespi BJ (2012) Island phytophagy: explaining the remarkable diversity of plant-feeding insects. Proceedings of the Royal Society B, published online 2 May 2012 (PDF)


Ryan CP and Crespi BJ (2012) Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility. Evolutionary Applications, published online 11 June 2012 (PDF)


Dinsdale N and Crespi BJ (2012) The borderline empathy paradox:  evidence and conceptual models for empathic enhancements in borderline personality disorder. Journal of Personality Disorders (in press) (PDF)