Edward F. Domino, M.D.

Dr. Domino has broad interests in translational basic to clinical pharmacology. His research includes several unifying themes in neuropsychopharmacology. These include a number of brain chemical messengers: acetylcholine, dopamine, endogenous opioids, glutamic acid, etc. Transmitters and receptors are involved in the central action of many different drugs. The mechanisms of tobacco and marijuana dependence are topics for periodic laboratory funded research. Brain imaging methodologies such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) are used by his laboratory extensively at University Hospital and Bioengineering on North Campus. Current funded research is on the role of NMDA antagonists of glutamic acid such as ketamine on imaging functional brain connectivity in normal, mentally depressed, and chronic pain volunteers. Selected highly motivated students and fellows are invited to participate.