My laboratory focuses in understanding how the bone marrow (the organ that produces blood cells) functions. We know that hematopoietic stem cells (HSC) are the ultimate source of all blood cells. They reside in specific niches formed by blood vessels, perivascular (LepR+ and Ng2+) and megakaryocytes in the bone marrow that maintain and regulate them. While many of the signals that regulate HSC and their niches have been identified we know very little about how the bone marrow senses and respond to changes in its environment.  How it adjusts blood cell production to organism demand? How does it sense hematopoietic injury and responds to restore homeostasis? What are the mechanisms that determine the size of the hematopoietic stem cell niche? How are the different components of the HSC niche regulated? Answering these questions is important because it will allow us to develop new therapeutic approaches to promote blood cell production during disease (for example bone marrow failure and leukemia or lymphoma). It will also allow us to manipulate bone marrow niches to promote recovery after hematopoietic stem cell transplantation, bone marrow failure or blood cancer. Read more about our research.
Primary Investigator
Daniel Lucas-Alcaraz

Daniel Lucas-Alcaraz, Ph.D. Assistant Professor
dlucasal@umich.edu 
734-764-4644

Address:
109 Zina Picther Place
Office: 3065a
Lab: 3051-3054
Ann Arbor, MI 48109