Research

Pancreatic Cancer Research
Pancreatic Cancer Research

Cancer cells within a pancreatic tumor are exposed to severe physical and oxidative stress and are deprived of oxygen and nutrients. Despite such unfavorable circumstances for survival, these cells are able to persist and grow. Predictably, metabolism is rewired. A major focus of the Lyssiotis lab is aimed at defining metabolic alterations in pancreatic cancer to guide the development of diagnostic and prognostic markers, new drug targets and therapies.

Tumor Metabolism Research
Tumor Metabolism Research

Cancer cells have different metabolic requirements than their normal counterparts. What do such differences mean and can we exploit them for therapeutic beneļ¬t? See link for an introduction to cancer metabolism and the efforts by the Lyssiotis lab to understand how and why cancer cells differ metabolically from normal cells.

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Immunometabolism Research
https://sites.google.com/a/umich.edu/costaslyssiotislab/research/reprogramming-research

The fate and function of cells in the immune system are intrinsically linked to their metabolic properties. The emerging field of immunometabolism seeks to define the pathways that regulate effector function in the many diverse immune cell lineages. See link to learn more about immunometabolism and how the Lyssiotis lab is employing these principles to harness the potential of the immune sysmtem to target and destroy cancer cells.

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