Reviews & Commentaries

Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer
Halbrook CJ, Lyssiotis CA. Cancer Cell (2017) 31:5-19.
Abstract | PDF

Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant Kras-Driven Cancers
Shah Y, Lyssiotis CA. Gastroenterology (2016) 151:798-801.

A Novel Small-Molecule Inhibitor of 3-Phosphoglycerate Dehydrogenase
Mullarky E, Lairson LL, Cantley LC, Lyssiotis CAMolecular and Cellular Oncology (2016) 3:e1164280.

Metabolic Reprogramming by the PI3K/AKT-mTOR Pathway in Cancer
Lien E, Lyssiotis CA, Cantley LC. In: Recent Results in Cancer Research. Metabolism in Cancer. New York, NY. Springer Publishing GroupKramer T, Schmitt CA. eds. (2016) 207:3972.
Abstract | PDF

Designing a Broad-Spectrum Integrative Approach for Cancer Prevention and Treatment
Getting to Know Cancer Taskforce*. [*member of >200 author taskforce] Seminars in Cancer Biology (2015) 35S, S276S304.

Dysregulated Metabolism Contributes to Oncogenesis
Hirschey MD, *DeBerardinis RJ, *Diehl AME, *Drew J, *Frezza C, *Green MF, *Jones LW, *Ko YH, *Le A, *Lea MA, *Locasale JW, *Longo VD, *Lyssiotis CA*McDonnell E, *Mehrmohamadi M, *Michelotti G, *Muralidhar V, *Murphy MP, *Pedersen P, *Poore B, *Raffaghello L, *Rathmell JC, *Sivanand S, *Vander Heiden MG, *Wellen KE; Target Validation Team. [*equal contribution; authors listed alphabetically] Semin Cancer Biol (2015) 35S, S129S150.

Acetate Fuels the Cancer Engine
Lyssiotis CA, Cantley LC. Cell (2014) 159, 1492–1494.

Fluxing Through Cancer: Tracking the Fate of 13C-Labeled Energy Sources in Cancer Cells and Mouse Tumors
Lyssiotis CA, Breitkopf SB, Yuan M, Bellinger G, Asara JM. Cambridge Isotope Labs (2014) Application Note 34. 

Targeting Metabolic Scavenging in Pancreatic Cancer
Lyssiotis CA, Cantley LC. Clinical Cancer Research (2014) 20, 6–8.

Metabolic Syndrome: F Stands for Fructose and Fat
Lyssiotis CA, Cantley LC. Nature (2013) 502, 181–182.

Pancreatic Cancers Rely on a Novel Glutamine Metabolism Pathway to Maintain Redox Balance
Lyssiotis CA, Son J, Cantley LC, Kimmelman AC. Cell Cycle (2013) 12, 1987–1988.

SIRT6 Puts Cancer Metabolism in the Driver’s Seat
Lyssiotis CA, Cantley LC. Cell (2012) 151, 1155-1156.

Small Molecule-Based Approaches to Adult Stem Cell Therapies
Lairson LL, Lyssiotis CA, Zhu S & Schultz PG. Annual Review of Pharmacology and Toxicology (2013) 6, 107–125.

Emerging Concepts: Linking Hypoxic Signaling and Cancer Metabolism
Lyssiotis CA, Vander Heiden MG, Muñoz-Pinedo C, Emerling BM. Cell Death and Disease (2012) 3, e303.

Cellular Control Mechanisms that Regulate Pyruvate Kinase M2 Activity and Promote Cancer Growth
Lyssiotis CA, Anastasiou D, Locasale JW, Vander Heiden MG, Christofk HR, Cantley LC. Biomed Research (2012) 23, 213–217. 

Chemical Control of Stem Cell Fate and Developmental Potential
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Angewandte Chemie (2011) 50, 200–242.
Abstract | PDF | German | Times cited: 83

Insight into the Reprogramming of Cell Fate with Small Molecules 
Lyssiotis CA. Graduate Thesis (2010).
Link | PDF

Reprogramming Developmental Potential
Lyssiotis CA, Charette BD & Lairson LL. In: Emerging Technology Platforms for Stem Cells (2009) New York, NY. John Wiley & Sons Press, Inc.; 51–85. Lakshmipathy U, Chesnut JD & Thyagarajan B, eds.
Summary | PDF

Cautiously Interpret Data
Lyssiotis CA. Chemical & Engineering News (2007) Nov-12, 6.