Publications (selected from more than 50)

Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer
Halbrook CJ, Lyssiotis CA. Cancer Cell (2017) 31:5-19.
Abstract | PDF

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, *Lyssiotis CA [co-senior authors], *Kimmelman AC. Nature (2016) 25, 479-483.
Abstract | PDF

Targeting Glutamine Metabolism Sensitizes Pancreatic Cancer to PARP1-driven Metabolic Catastrophe Induced by ß-lapachone
Chakrabarti G, Moore Z, Luo X, Ilcheva M, Ali A, Anderson GG, Padanad M, Scaglioni PP, Cantley LC, Kimmelman AC, DeBerardinis RJ, *Lyssiotis CA [co-senior authors], *Boothman DA. Cancer & Metabolism (2015) 3, 12.
Abstract PDF 

Oncogene Ablation-Resistant Pancreatic Cancer Cells Depend on Mitochondrial Function
Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sanchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Carugo A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming J, Cantley LC, DePinho R & Draetta G. Nature (2014) 30, 628–632.
Abstract | PDF | Extended Figures | Times cited: 164

Glutamine Supports Pancreatic Cancer Growth Through a KRAS-Regulated Metabolic Pathway
*Son J, *Lyssiotis CA [*co-lead authors], Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC & Kimmelman AC. Nature (2013) 496, 101–105.

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
*Ying H, *Kimmelman AC, *Lyssiotis CA [*co-lead authors], Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik J, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC & DePinho RA. Cell (2012) 149, 656–670.