Research




 
Welcome

We study how proteins work via conformational changes, posttranslational modifications, and protein:protein interactions. Our research areas include proteins in the nitric oxide-sGC-cGMP pathway crucial to the cardiovascular system, nitrogen oxides modifications, non canonical protein:RNA interactions, ligand:protein interactions and novel methods to detect protein:protein interactions.

Our expertise, including molecular biology, biochemistry, spectroscopy, x-ray crystallography, and small-angle x-ray scattering, allows us to answer key questions regarding enzyme catalysis, inhibition, recognition, and structural plasticity.
 







Current lab projects

  GAPDH - RNA  
sGC
 
 
BICXS
 
 
   GAPDH - RNA
Exploring the non-canonical binding of RNA by glyceraldehyde-3-phosphate dehydrogenase
  sGC 
Gaining insights into the structural biochemistry of soluble
guanylate cyclase
  BICXS
Developing a model system for imaging biomolecular interactions using coherent x-ray scattering