Professor Wong is jointly appointed in the Department of Biological Sciences (Faculty of Science) and the Department of Medicine (Faculty of Medicine and Dentistry). He identifies and develops novel applications made possible by exponential cost reductions in DNA/RNA sequencing. His work is not organism specific and many different areas of biological and/or medical research are covered. The only commonality is that computational analysis has a defining role in all of his projects.

Many of the activities conducted at the University of Alberta center on the use of sequencing to identify microbial agents in clinical samples. Examples include detection of retroviral integration in host genomes, capture based detection of ultra-low copy number viral infections, and metagenomic characterization of bacterial populations in the human gut (especially in fecal transplants). Another area of research employs single-cell omics to characterize the genetic changes underlying cancer metastasis.

Dr. Wong is active in many international collaborations, in part because of his long association with BGI-Shenzhen, the world's largest sequencing research organization. He leads a multi-disciplinary consortium that has sequenced the transcriptomes of over 1000 plant species across the Viridiplantae, covering to a first approximation every plant family known to science. Among the spin-offs from this effort is a program to develop molecular tools for neurosciences (i.e. optogenetics).