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Chemical Biology, Enzymology and Spectroscopy

Research in the Tonge laboratory focuses on two major areas: (i) inhibitor discovery and the mechanism of drug action, and (ii) photoreceptor biophysics and biology. We design and synthesize inhibitors of enzyme drug targets involved in infectious diseases and cancer, and use techniques such as mass spectrometry and positron emission tomography to explore the role of drug-target binding kinetics in drug activity at the cellular and whole organism level. We also use biophysical methods such as ultrafast spectroscopy coupled with site-specific protein modification to understand the mechanism of photoreceptor activation as a prelude to the development of optogenetic devices.

Tonge Group - Summer 2015


 


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