Research

Chemical Biology in the Sampson Lab

Work in the Sampson laboratory focuses on the relationship between protein structure and protein function.  The functions of different protein systems ranging from bacterial cholesterol metabolism to mammalian fertilization have been elucidated using synthetic, analytical, and biochemical methods, including the development of methodology for the synthesis of new polymer structures. We are a very multi-disciplinary group with students from the Chemistry, Molecular Pharmacology, and Biochemistry and Structural Biology Graduate Programs all working side-by-side at the bench. 

Currently, we have two main research foci in our laboratory: Tuberculosis and Polymers. Both of these research areas require interdisciplinary work ranging from synthesizing inhibitors and substrates to investigating in vivo mechanism of action.