Luk Laboratory

Ed Luk, PhD
Associate Professor
Renaissance School of Medicine
Stony Brook University
Department of Biochemistry and Cell Biology

410 Life Sciences Building
Stony Brook, NY 11794-5215
Office telephone: 631-632-1903


Research Description

Histone proteins are major constituents of the chromosome. DNA wraps around histones to form repeating structural units called nucleosomes. Nucleosomes can then stack onto each other to fold the genomic DNA into a compact, organized structure within the nucleus. For the transcription machinery to ‘read’ the underlying genetic information, the histones must be reorganized and removed at some points. We study the molecular events that mobilize histones to allow the transcription machinery to engage the DNA and turn a gene on or off.