Faculty‎ > ‎

Yun Tan, M.D., Ph.D








Associate Professor
School of Medicine 
Schwitalla Hall, M402
email: tany@slu.edu
314-977-8041


Education:
Ph.D., Saint Louis University, 1999 
M.D., Binzhou Medical College, 1985


Teaching Responsibilities:

Medical Courses:

Introduction to Clinical Anatomy Module (A-100) 2008-present 
Global Health Learning Community (GHLC-106), Course Director, 2010-present
Prematriculation Program, Supervisor, 2011-present

Graduate Courses:
Human Gross Anatomy (ANAT-5000), Course Director, 2008-present
Advanced Dissections in Human Anatomy (ANAT-5500), Course Director, 2010-present

Service Courses:
Human Gross Anatomy for AHP (ANAT-4000), Course Director, 2008-present
Human Gross Anatomy for Physician Assistants ANAT-4100, Course Director, 2008-present


Faculty Appointments:

Associate Professor
Department of Surgery
Center for Anatomical Science and Education
Saint Louis University School of Medicine
2015-present

Assistant Professor
Department of Surgery
Center for Anatomical Science and Education
Saint Louis University School of Medicine
2007-2015


Professional Experience:

Research Associate 
Department of Biochemistry and Molecular Biology
Saint Louis University School of Medicine
2001-2007

Postdoctoral Fellow 
Department of Pharmacological and Physiological Science
Saint Louis University School of Medicine
1999-2001

Chief Resident
Department of Emergency Medicine 
Affiliated Hospital of Qingdao Medical College (China)
 01/1991 - 07/1992 

Resident
Department of Emergency Medicine 
Affiliated Hospital of Qingdao Medical College (China)
07/1985-12/1990

                         

Publications:

Heldermon CD, Ohlemiller KK, Herzog ED, Vogler C, Qin E, Wozniak DF, Tan Y, Orrock JL, Sands MS.  Therapeutic efficacy of bone marrow transplant, intracranial AAV-mediated gene therapy, or both in the mouse model of MPS IIIB.  Mol Ther. 2010 May; 18(5):873-80.

Macauley SL, Wozniak DF, Kielar C, Tan Y, Cooper JD, Sands MS.  Cerebellar pathology and motor deficits in the palmitoyl protein thioesterase 1-deficient mouse.  Exp Neurol. 2009 May;217(1):124-35.

Grubb JH, Vogler C, Tan Y, Shah G, MacRae A, Sly WS.  Infused Fc-tagged β-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8375-80. 

Montano AM1, Oikawa H, Tomatsu S, Nishioka T, Vogler C, Gutierrez MA, Oguma T, Tan Y,  Grubb JH, Dung VC, Ohashi A, Miyamoto K, Orii T, Yoneda Y, Sly WS.  Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice. Mol Genet Metab. 2008 Jun; 94(2):178-89. 

Grubb JH, Vogler C, Levy B, Galvin N, Tan Y, Sly WS.  Chemically modified beta-glucuronidase crosses blood–brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.  Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2616-21. 

Sly WS1, Vogler C, Grubb JH, Levy B, Galvin N, Tan Y, Nishioka T, Tomatsu S.  Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors.  Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15172-7. 

Vogler C, Levy B, Grubb J, Galvin N, Tan Y, Kakkis E, Pavloff, N, Sly WS.  Overcoming the blood brain barrier with high dose enzyme replacement therapy in murine MucopolysaccharidosisVII.  Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14777-82. 

Orii KO, Grubb JH, Vogler C, Tan Y, Markova K, Monte J, Waheed A, Vogler GA, Davidson BL, Orii T, Kondo N, Sly WS.  Defining the pathway for Tat-mediated delivery of beta-glucuronidase in cultured cells and MPS VII mice.  Mol Ther. 2005 Aug; 12(2):345-52.

Rauls RA1, Tan Y, Knuepfer MM.  Central beta-adrenoceptors mediate phasic and sustained components of hemodynamic responses to acute behavioral stress.  Brain Res. 2005 Jun 28;1048(1-2):98-107.

Hou Y, Tan Y, Belcheva MM, Clark AL, Zahm DS, Coscia CJ.  Differential effects of gestational buprenorphine, nalozone, and methadone on mesolimbic u opioid and ORL1 receptor G protein coupling.  Brain Res Dev Brain Res. 2004 Jul 19; 151(1-2):149-57.

Belcheva MM1, Tan Y, Heaton VM, Clark AL, Coscia CJ.  Mu opioid transactivation and down-regulation of the epidermal growth factor receptor in astrocytes: implications for mitogen-activated protein kinase signaling.  Mol Pharmacol. 2003 Dec; 64(6):1391-401.

Tan Y, Gan Q, Knuepfer MM.  Central alpha-adrenergic receptors and corticotropin releasing factor mediate hemodynamic responses to acute cold stress.  Brain Res. 2003 Apr 4;968(1):122-9.

Belcheva MM, Haas PD, Tan Y, Heaton VM, Coscia CJ.  The fibroblast growth factor receptor is at the site of convergence between mu-opioid receptor and growth factor signaling pathways in rat C6 glioma cells.  J Pharmacol Exp Ther. 2002 Dec; 303(3):909-18.

Tan Y, Williams ES, Lancia AJ, Zahm DS.  On the altered expression of tyrosine hydroxylase and calbindin-D 28kD immunoreactivities and viability of neurons in the ventral tegmental area of Tsai following injections of 6-hydroxydopamine in the medial forebrain bundle in the rat. Brain Res. 2000 Jun 30; 869(1-2):56-68.

Tan Y, Williams ES, Zahm DS.  Calbindin-D 28kD Immunofluorescence in ventral mesencephalic neurons labeled following injections of Fluoro-Gold in nucleus accumbens subterritories: inverse relationship relative to known neurotoxin vulnerabilities.  Brain Res. 1999 Oct 9;844(1-2):67-77.

Meredith GE, Farrell T, Kellaghan P, Tan Y, Zahm DS, Totterdell S.  Immunocytochemical characterisation of catecholaminergic neurons in the rat striatum following dopamine-depleting lesions.  Eur J Neurosci. 1999 Oct; 11(10):3585-96.

Panneton WM, McCulloch PF, Tan Y, Tan YX, Yavari P.  Brainstem origin of preganglionic cardiac motoneurons in the muskrat.  Brain Res. 1996 Nov 4; 738(2):342-6.

Tan Y, Brog JS, Williams ES, Zahm DS.  Morphometric analysis of ventral mesencephalic neurons retrogradely labeled with Fluoro-Gold following injections in the shell, core and rostral pole of the rat nucleus accumbens.  Brain Res. 1995 Aug 14; 689(1):151-6.


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