Faculty‎ > ‎

Daniel L. Tolbert, Ph.D.

Dr. Daniel L. Tolbert is Professor Emeritus of the Center for Anatomical Science and Education.  Dr. Tolbert received his doctorate in Anatomy at Saint Louis University in 1975. 

Dr. Tolbert's area of research interest is anatomical studies of hereditary neuronal degeneration.

Ph.D., Saint Louis University, 1975

Professor Emeritus
(314) 977-7390

Academic Appointments
Assistant Professor of Anatomy, Saint Louis University, 1978-1983
Assistant Professor of Surgery (Neurosurgery), Saint Louis University, 1978-1988
Associate Professor of Anatomy & Neurobiology, Saint Louis University, 1983-1988
Professor of Anatomy and Neurobiology, Saint Louis University, 1988-
Associate Professor of Surgery, Saint Louis University, 1988-1994
Professor of Surgery, Saint Louis University, 1994-
Director, Center for Anatomical Science and Education, Saint Louis University, 2004-2014

Community Service

  • Triad Community Unit District 2 Board of Education,
    Board Member, 1991-99
    Secretary, 1995-97
    Vice President, 1997-99
  • James S. McDonnell USO, Volunteer, 1999-
  • National Alumni Board Quincy University 2000-
    President, 2004-

Anatomical studies of hereditary neuronal degeneration.


Recent Publications

Wolf, L.W., LaRegina, M.C. and Tolbert, D.L. A behavioral study of the development of hereditary cerebellar ataxia in the shaker rat mutant. Behav. Brain Res. 75:67-81, 1996.

Tolbert, D.L. and Gutting, J.C. Quantitative analysis of cuneocerebellar projections in rats: differential topography in the anterior and posterior lobes. Neuroscience, 80:359-371, 1997.

Alisky, J.M. and Tolbert, D.L. Quantitative analysis of converging spinal and cuneate mossy fiber afferent projections to the rat cerebellar anterior lobe. Neuroscience, 80:373-388, 1997.

Tolbert, D.L. and Heckroth, J. Purkinje cell transplants in shaker mutant rats with hereditary Purkinje cell degeneration and ataxia. Exp. Neurol. 153:255-267, 1998.

Clark, B.L. and Tolbert, D.L. X-linked transmission of the shaker mutation in rats with hereditary Purkinje cell degeneration and ataxia. Brain Res. 858:264-273, 2000.

Busiguina, S., Fernandez, A.M., Barrios, V., Tolbert, D.L., Clark, R., Berciano, J. and Torres-Aleman, I. Neurodegeneration is associated to changes in serum insulin-like growth factors. Neurobio. Dis. 7:657-665, 2000.

Tolbert, D.L. and Clark B.R. Olivocerebellar projections modify hereditary Purkinje cell degeneration. Neuroscience. 101:417-433, 2000.

Tolbert, D.L., Bradley, M.W., Tolod, E.G., Torres-Aleman, I. and Clark, B.R. Chronic intraventricular infusion of glial cell line-derived neurotrophic factor (GDNF) rescues some cerebellar Purkinje Cells from heredodegeneration. Exp. Neurol. 170:375-379, 2001.

Tolbert, D.L. and Knight, T. Persistence of spinocerebellar afferent topography following hereditary Purkinje cell degeneration. The Cerebellum 2:31-38, 2003.

Tolbert, D. L. and Clark, B.R. GDNF and IGF-I trophic factors delay hereditary Purkinje cell degeneration and the progression of gait ataxia. Exp. Neurol. 183:205-19, 2003.

Hess, B.H., Krewet, J.A., Tolbert, D.L., Olivocerebellar projections are necessary for exogenous trophic factors to delay heredo-Purkinje cell degeneration. Brain Res. 986:54-62, 2003.

Tolbert, D. L., Conoyer, B. and Ariel, M., Quantitative Analysis of Granule Cell Axons and Climbing Fiber Afferents in the Turtle Cerebellar Cortex. Anat. Embyo. 209:49-58, 2004.

Clark, B.R., Horwitz, D. and Tolbert, D., Temporal-spatial patterns of hereditary Purkinje cell degeneration correlated with movement behaviors. (In preparation)


Basic Clinical Neuroscience, P.A. Young, P.H. Young and D.L. Tolbert, 2nd ed., Lippincott Williams and Wilkins, 2007.