Center for Anatomical Science and Education

Mission Statement

The Center for Anatomical Science and Education is committed to providing innovative scholarship and effective teaching in all aspects of the structure of the human body, offering training programs in anatomy for graduate students, assisting in M.D. and Ph.D. postdoctoral training, and stimulating interest in research and technical expertise by active participation in a variety of research projects.



  • The CASE sponsored Annual Gift Body Interfaith Memorial Service was held at St. Francis Xavier College Church November 6, 2015.
  • Mohammed Waheed Rana, Ph.D. was honored November 5, 2015 at the Interfaith Partnership of Greater St. Louis 30th Anniversary Dinner & Celebration for his decades of exemplary leadership in the interfaith community.  His relationships played a key role in securing greater St. Louis' acceptance of the building of the Daar-ul-Islam Masjid in Ballwin MO.  Dr. Rana is often called upon as a speaker and representative of Islam.  He has previously been commended with the Malachi Award for Interfaith Relations and Understanding.  His untiring commitment and friendship have touched the hearts of many in St. Louis.
  • CASE faculty and students recently participated in the SLU Center for Neuroscience 1st Annual Research Symposium on October 30, 2015.
    • Dan T. Daly, CASE graduate student, presented a poster entitled, "The commissure connecting both sides of the turtle lateral cerebellum is myelinated and travels in the Purkinje Cell Layer."
    •  Solomon Segal, M.D. presented a co-authored poster entitled, "Development of a Methodology for Visualization and Geometric Characterization of Myelinated White Matter Neural Fibers."
    • Joshua W. Little, D.C., Ph.D. was a co-author of a poster entitled, "Novel A3 Adenosine Receptor Agonists As Analgesics In Chronic Neuropathic Pain." 
  • Solomon Segal, M.D. was an invited speaker at the international symposium, "Vesalius and the Invention of the Modern 
  • Body." This interdisciplinary symposium was created to celebrate the 500-year anniversary of the birth of Andreas Vesalius (1514-1564), founder of the study of modern human anatomy, and join internationally recognized experts to examine his work, De humani corporis fabrica. Dr. Segal gave a presentation entitled, "Fabrica Guided Neo-Vesalian Public Anatomy of the Brain Ventricular System 500 Years Later at Saint Louis University." His presentation explored the historical, humanistic, and anatomical synergies reflected in the work of Andreas Vesalius. 
  • Joshua W. Little, D.C., Ph.D. was the first author of 
    a recent 
    publication in the journal, BRAIN. 
    Dr. Little was part of an international team of researchers together with lead researcher, Daniela Salvemini, Ph.D., that demonstrated activation of the adenosine receptor subtype A3  in the spinal cord and brain can alleviate several neuropathic pain states. Local, national (e.g., ScienceDaily and Medical News Today) and international [e.g. The Independent (UK),  La tampa(Turin), Berliner Kurier (Berlin), El Imparcial(Mexico), Al Jazeera (Turkey), Times of India] science and news media have reported this discovery as a potential "off switch" for chronic pain.  
  • Joshua W. Little, D.C., Ph.D. was featured in the National University of Health Sciences websiteHe was interviewed about his recent publication in the journal BRAIN.
  • Joshua W. Little, D.C., Ph.D. was featured in the Springfield News-Leader. He was interviewed about his career in pain research.
  • Joshua W. Little, D.C., Ph.D. was featured on the Evangel University website for his Distinguished Alumnus Award.
  • The CASE sponsored Annual Gift Body Interfaith Memorial Service was held at St. Francis Xavier College Church November 7, 2014.


  • John R. Martin, Ph.D. was honored with a SLU Student 
  • Government Association Faculty Excellence Award at a special ceremony on 04/12/15 at the Pere Marquette Gallery. The Faculty Excellence Awards were developed to recognize distinguished SLU faculty members. Nominations for the awards come from the SLU community with an emphasis on student nominations.
  • Joshua W. Little D.C., Ph.D.  was recently awarded 
    the inaugural Department of Kinesiology Distinguished Alumnus from Evangel University on 10/9/2014.

Joshua W. Little D.C., Ph.D. received the American Pain Society Young Investigator Travel Award to attend the 2014 33rd annual conference in Tampa, FL.. He will present his abstract entitled, "Central adenosine A3 receptor (A3AR) activation reverses neuropathic pain."

Recent Publications

  • W. Michael Panneton, Qi Gan, Michael Ariel, Injections of Algesic Solutions into Muscle Activate the Lateral Reticular Formation: A Nociceptive Relay of the Spinoreticulothalamic Tract. Public Library of Science. 2015 July 8.
  • Little J.W., Grieve, T., Cramer G.D., Rich J., Laptook E., Stiefel J., Linaker K, Quantifying Osteoarthritic Changes of the Zygapophyseal Joints From Radiographs: A Reliability Study. Journal of Manipulative and Physiological Therapeutics. 2015 Jun 25. pii: S0161-4754(15)00069-X. doi: 10.1016/j.jmpt.2014.12.009. [Epub ahead of print]
  • Ford A, Castonguay A, Cottet M, Little J.W., Chen Z, Symons-Liguori A.M., Doyle T, Egan T.M., Vanderah TW, De Konnick Y, Tosh DK, Jacobson KA, and Salvemini D. Engagement of the GABA to KCC2 Signaling Pathway Contributes to the Analgesic Effects of A3AR Agonists in Neuropathic Pain. J of Neuroscience, 15 April 2015, 35(15): 6057-6067; doi: 10.1523/JNEUROSCI.4495-14.2015
  • Little J.W., Ford A., Symons-Liguori A.M., Chen Z., Janes K., Doyle T., Bannister K., Xie J., Tosh D.K., Dickenson A., Vanderah T.W., Porreca F., Jacobson K., and Salvemini D. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain. 2014. DOI: First published online: 20 November 2014. PMID: 25414036.
  • Janes K., Wahlman C., Little J.W., Doyle T., Tosh D.K., Jacobson K.A., and Salvemini D. Spinal neuroimmmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy. Brain, Behavior, and Immunity. 2014 Sep 8. pii: S0889-1591(14)00427-9
  • Janes K., Little J.W., Li C., Bryant L., Chen C., Chen Z., Kamocki K., Doyle T., Snider A., Esposito E., Cuzzocrea S., Bieberich E., Obeid L., Petrache I., Nicol G., Neumann W.L., and Salvemini D. The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1. J Biol Chem. 2014, Jul 25;289(30):21082-21097. Epub 2014 May 29.

Graduate Student News

  • Dan T. Daly, CASE graduate student, presented a poster entitled, "The commissure connecting both sides of the turtle lateral cerebellum is myelinated and travels in the Purkinje Cell Layer." at the Society for Neuroscience 45th Annual Meeting on Monday, October 19, 2015,
  • Solomon Segal M.D. from CASE/Surgery was the dissertation advisor for Ajit George, a Ph. D. candidate in Biomedical Engineering. Ajit successfully defended his dissertation, "Development of a Methodology for Visualization and Geometric Characterization of Myelinated White Matter Neural Fibers," on Aug. 17, 2015. He was the first Ph.D. graduate student from SLU Department of Bioengineering. Along with Dr. Segal, this project was the result of a collaborative effort between SLU SOM and Parks College including faculty from five SLU departments: Departments of Biomedical Engineering (Dr. Gary Bledsoe), Surgery (Dr. Segal) Electrical and Computer Engineering (Dr. William Ebel), Pharmacology and Physiology (Dr. Michael Ariel) and Pathology (Dr. Grant Kolar). Dr. Segal's laboratory remains engaged in the study of the white matter fiber structure with a view to validate clinical observations by diffusion MRI.  
  • Akiva Katz successfully completed the M.S. (Project) degree in Anatomy Thursday July 23, 2015.  His project was entitled:  “A Video Tutorial for Anatomical Dissection”
  • Jessica McFarland successfully completed the M.S. (Project) degree in Anatomy Wednesday July 22, 2015.  Her project was entitled:  “Lumen Diameter of the Left Coronary Artery in Relation to Left Ventricular Wall Thickness, Length, Age, and Gender”
  • George Diab successfully completed the M.S. (Project) degree in Anatomy Wednesday May 6, 2015.  His project was entitled:  “An Interactive Atlas of the Superficial Face and the Temporomandibular Joint”
  • Dan Daly presented a paper entitled, "A neural mechanism for exacerbation of headache by light" by Noseda et al. 2010 on February 5, 2015 for CASE Journal Club.
  • John Merlo presented a paper entitled, "Rat Model of Lumbar Facet Joint Osteoarthritis Associated With Facet-mediated Mechanical Hyperalgesia Induced by Intra-articular Injection of Monosodium Iodoacetate" by Gong et al. 2011 on January 29, 2015 for CASE Journal Club.
  • Jessica McFarland presented a paper entitled, "Coronary CT angiography for the detection of coronary artery stenosis in patients referred for transcatheter aortic valve replacement" by Hamdan et al. 2015 on January 22, 2015 for CASE Journal Club.
  • Akiva Katz presented a paper entitled, "Increased Interleukin-1α and Prostaglandin E2 Expression in the Spinal Cord at 1 Day After Painful Facet Joint Injury " by Hamdan et al. 2015 on January 15, 2015 for CASE Journal Club.
  • Eric Brown successfully completed the M.S. (Project) degree in Anatomy Friday December 12, 2014.  His project was entitled:  “A Foundational White Matter Atlas of Dissected Human Brain Specimens”