Welcome to the Harrity Group Website. Here you can find out more information about our research group, as well as current research interests and projects. You can also find links to General research Topics that we have discussed in group meetings, as well as links to a range of useful resources. We hope that you find this site useful and if you require any further information, then feel free to contact me directly.



   
   
   
         
   
 
   
Cu-Promoted Sydnone Cycloadditions of Alkynes: Scope and Mechanism Studies 
Júlia Comas-Barceló, Robert S. Foster, Béla Fiser, Enrique Gomez-Bengoa & Joseph P. A. Harrity* Chemistry a European Journal
 
   
           
   
Vamos Cobre!: Cu salts have been found to promote the cycloaddition reaction of sydnones and terminal alkynes, providing significant reduction  in reaction times. Specifically, the use of Cu(OTf)2 is found to provide 1,3-disubstituted pyrazoles, whereas simply switching the promoter system to Cu(OAc)2 allows the corresponding 1,4-isomers to be produced. The mechanism of the Cu-effect in each case has been investigated by experimental and theoretical studies, and they suggest that Cu(OTf)2 functions by Lewis acid activation of the sydnone, whereas Cu(OAc)2 promotes formation of reactive CuI acetylides.
   
           
   
A Nickel-Catalyzed Benzannulation Approach to Aromatic Boronic Esters

Anne-Laure Auvinet & Prof. Joseph P. A. Harrity* Angew. Chem. Int. Ed. 
   
           
   
Off and On: A nickel catalyzed benzannulation of alkynylboronates provides functionalized phenols with high levels of chemo- and regioselctively. While transmetalation of organoboron intermediate to organonickel does not occur during cycloaddition, it is “switched on” by addition of base,  thus allowing a one-pot benzannulation and cross-coupling to be realized (see scheme; Pin = pinacolato, Ms=mesyl)
   
           
   
   
 
 
http://www.peakdale.co.uk/products/latest-products/boronates-may-2012.html
 
https://sites.google.com/a/sheffield.ac.uk/echonet-itn/
 
https://sites.google.com/a/sheffield.ac.uk/cosshnet-eid-itn/home

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