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Sarcoidosis Disease


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My belief is that you need to research and educate yourself in relation to Sarcoidosis (see What is Sarcoidosis). The medical profession seems to be somewhat divided. Some even saying that in the majority of cases that Sarcoidosis will disappear (see Myths of Sarcoidosis). From what I have heard from those with Sarcoidosis this is not the case and the disease continues to haunt us throughout our lives. 

Everyone has a choice concerning the course of treatment you follow. Some follow the route of Prednisone and Methotrexate (see Conventional Treatments for Sarcoidosis) while others are following antibiotic therapy believing that Sarcoidosis is caused by a bacteria (see Bacterial Etiology of Sarcoidosis). Others take natural therapies. 

Which ever route you choose its your choice. Please talk to others and learn from their experience - then make up your own mind.

If I have missed a link that could help others please email me at support@sarcoidosisaustralia.com

Sarcoidosis also called Sarcoid, Besnier-Boeck or Besnier-Boeck-Schaumann Disease and is an inflammatory disease. It is described by Chronic Illness Recovery as a chronic, progressive, systemic disease that can gradually reduce the quality of life. (see Sarcoidosis Information)

The Cleveland Clinic describes Sarcoidosis as an inflammatory disease and goes on to say that: In the medical world, inflammation causes a litany of health issues.  Ranging from arthritis to bowel disease, from skin disease to cancer.  It occurs as a result of a change in our immune system. 

What is sarcoidosis

Sarcoidosis is an illness that results from inflammation.  A rather common condition, sarcoidosis is an immune disease that causes abnormal inflammation of cells in the body.  Sarcoidosis can affect the lungs, eyes, and other organs – including the heart and brain in the most severe cases.

Dr. Daniel Culver, a leader in the treatment of sarcoidosis, and a staff physician for the Respiratory Institute at Cleveland Clinic empathizes with his patients.

“People look at them and say, ‘you don’t look sick’, but the truth is, these patients are very ill,” Dr. Culver says.  “It’s difficult to cope with something that many people don’t understand.”

What’s more, the disease is not fully understood by researchers, and extremely difficult to diagnose.  The cause of the disease is unknown, but studies have shown that it is more common among African Americans and females, and often occurs before the age of forty.

Sarcoidosis is often overlooked

On average, people with sarcoidosis in their lungs will pay five visits to the doctor before being properly diagnosed.  Almost all patients have lung, or chest symptoms including chest pain, dry cough, and shortness of breath.

“Sarcoidosis is often overlooked because it manifests in a number of different ways, and presents itself with a number of different symptoms depending on the inflamed area of the body,” says Dr. Culver.  “Physicians assume bronchitis or asthma when they hear wheezing, or worse, cancer, when they see enlarged lymph nodes in the lungs.”

How sarcoidosis can be diagnosed

Diagnosis usually requires an X-ray or CAT scan followed by a biopsy, and the biopsy doesn't prove the existence of the disease until other conditions are excluded.

With all of the complexity involved, patients are often left with questions on how to cope.

At this point, there is no cure for sarcoidosis, but one-half to two-thirds of patients with sarcoidosis will have the disease go away on its own over time, says Dr.Culver.

The exact cause of sarcoidosis is not known. The disease can appear suddenly and then disappear, or it can develop gradually and produce symptoms that come and go for a lifetime.

Researchers believe that the disease is caused by an abnormal immune response. (The body’s defense system does not react as it should to a foreign substance "intruder.")    

In a healthy person, inflammation occurs as the cells of the body’s immune system come together to fight the intruder at an organ or tissue site. In a person with sarcoidosis, however, cells that come to fight end up clumping together into small lumps called granulomas.

It’s still uncertain which foreign substance "triggers" the body’s abnormal response. Some researchers suggest that fungi, viruses, or bacteria are likely triggers. In fact, cases of sarcoidosis have occurred in groups of people who had close contact with each other, as well as in recipients of heart, lung and bone marrow transplants. But, so far, no data have been able to convincingly and consistently establish this "infectious" connection as the cause of the disease. However, some types of bacteria have recently emerged as possible candidates and continue to be closely studied.

For a complete history of Sarcoidosis please see the attachment at the end of this page.

See Symptoms of Sarcoidosis.

What Goes Wrong?

Macrophages are a type of white blood cell which kill bacterial invaders. Macro-phages are also called phagocytes, or ‘eating cells’. In fact, the word ‘ macro-phage’ means they are the ‘big eaters’.

In Sarcoidosis, macro-phages are highly activated, but not completely effective, so other macro-phages surround and wall off the infected macro-phages (the ones with bacteria inside them), joining together their cell material to form multi-nucleated giant cells with little or no dead material (necrosis) because the bacteria are still alive.

Macrophages must die

Successful macro-phages have to die to kill the engulfed enemy bacteria and complete the phagocytic process. Otherwise, bacteria may be able to live and even replicate safely inside the macro-phage and the human host will still be ill.

This could be disastrous, considering that the life span of a macro-phage may be months or even years. Bacteria can continue living and replicating inside macro-phages within granulomas. Even slowly-reproducing bacteria might establish a stronghold by living inside macro-phages.

Etiology

Recent research has revealed that sarcoidosis is caused by Th1 inflammation as a result of immune system dysfunction due to a chronic intracellular bacterial infection. 

See Infectious Etiology of Sarcoidosis

Diagnosis

Diagnosis rarely occurs early in the disease process and many symptoms are attributed to other causes (e.g., arthritis, fibromyalgia, chronic fatigue syndrome, migraines, etc.). 

See Diagnosing Sarcoidosis

Myths

The failure to recognize the extent of this disease process accounts for the myth of automatic remission:

See Myths About Sarcoidosis

Vitamin D and Sarcoidosis

One of the most important things for any sarcoidosis patient to learn is about Vitamin D. I have posted a simple explanation below.

History of vitamin D - Vitamin D was misnamed when it was discovered in 1922. It’s not a true vitamin because an ongoing nutrient source is not required to sustain normal levels in the body. Vitamin D is properly classified as a secosteroid hormone precursor. A hormone is a chemical substance produced by one organ and then transported in the bloodstream to a target organ, where it causes a specific biological action. 

This animated video focuses on emerging research around the importance of vitamin D's connection to a range of vital systems in the human body. 

Understanding Vitamin D

D-metabolites

Vitamin D has several metabolites (forms). For practical purposes, this explanation is limited to two metabolites: 25-D (inactive) and 1,25-D (active).

25-D

25-D (also known as calciferol, calcidiol, 25-hydroxycholecalciferol or 25-hydroxyvitamin-D) has a less active role in vitamin D metabolism than the more active 1,25-D but it does increase calcium absorption from the gut and, theoretically, acts (at high levels) as an antagonist on the Vitamin D Receptor. 25-D is produced in the liver and synthesized in the cells of the skin in reaction to sunlight. 25-D may also be obtained from naturally occurring dietary sources (especially fish, fish oils, liver, eggs), processed foods that are supplemented with vitamin D (dairy products, cereals, etc.) and vitamin supplements.

25-D is the major circulating form of vitamin D. It is used in the production of (1,25-D) in the kidneys.

D3 is the form of 25-D that comes from animals. it is also produced in the skin and is available in pill or capsule form.

1,25-D

1,25-D (also known as calcitriol or 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin-D3) is a potent secosteroid paracrine mediator and affects almost all cellular activity.

1,25-D is formed in the kidneys, the skin and many other tissues of the body. In addition, light falling in the eyes may cause generation of 1,25-D.

Testing your Vitamin D Levels

To verify inflammatory illness/Sarcoidosis and dysregulated vitamin D metabolism, we recommend measuring two D-metabolites:

1,25-dihydroxyvitamin-D (125-D)

25-hydroxyvitamin-D (25D or D2/D3).

Learn More about D-Metabolites and Diagnostic Tests

Learn more about the role of Vitamin D in Sarcoidosis


Other Links Below:

Marshall Protocol

The Sarcoidosis Centre

Etiology of Sarcoidosis: Does Infection Play a Role?

http://bacteriality.com/about-the-mp/

http://mpkb.org/

http://autoimmunityresearch.org/

Links from Chronic Illness Recovery

What is Sarcoidosis?

Myths About Sarcoidosis

Infectious Etiology of Sarcoidosis

Diagnosing Sarcoidosis

Symptoms of Sarcoidosis

Conventional Treatments for Sarcoidosis          

Scientific Studies

http://www.sarcoidcenter.com/

http://wwwnc.cdc.gov/eid/article/8/11/02-0318_article.htm

http://www.sarcoidosis.com.au/Publications/Sarcoidosis%20Publications/A%20prospective%20Study%20of%2032px%20w%20neuro.pdf

Patient Handouts Sourced from Medline  Plus

Interactive Health Tutorials

MedlinePlus presents interactive health tutorials from the Patient Education Institute. Learn about the symptoms, diagnosis and treatment for a variety of diseases and conditions. Also learn about surgeries, prevention and wellness. Each tutorial includes animated graphics, audio and easy-to-read language.





Dermatologic Manifestations of Sarcoidosis

About Helper T Cells

Calcium and Vitamin D in Sarcoidosis: How to Assess and Manage

Robert R. Burke1,2Benjamin A. Rybicki3D. Sudhaker Rao4
1 Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
2 Division of Pulmonary and Critical Care Medicine, Henry Ford Health System, Detroit, Michigan
3 Department of Research Epidemiology and Biostatistics, Henry Ford Hospital, Henry Ford Health System, Detroit, Michigan
4 Division of Endocrinology, Diabetes, and Bone and Mineral Disorders, Henry Ford Health System, Detroit, Michigan

ABSTRACTThe synthesis of vitamin D is altered by the granulomatous inflammation of sarcoidosis leading to increased production of 1, 25-dihydroxyvitamin D. Mounting evidence suggests that vitamin D is an immunomodulating hormone that inhibits both antigen presentation by cells of the innate immune system, and the cytokine release and proliferation of Th1 cells. These and other extraskeletal health benefits have led to an increase in vitamin D assessment and pharmacological supplementation in the general population. This review highlights the altered synthesis and general immunomodulating properties of vitamin D with a special emphasis on known interactions with sarcoidosis. In addition, the assessment of vitamin D nutritional status, its pharmacological supplementation, and the management of bone health in patients with sarcoidosis are reviewed. 

KEYWORDS: Sarcoidosis, vitamin D, 1, 25-dihydroxyvitamin D

Sarcoidosis-Morbus Besnier-Boeck-Schaumann


Our body's immune system is supposed to protect us from infection and disease, but there is a condition called "sarcoidosis" that actually causes a person's immune system to damage its own tissues.

In this "Faces of Rare Disease," Sabrina Sonnier talks about this diagnosis that could threaten every organ in her body.




Understanding Sarcoidosis with Daniel Culver, DOJoseph Parambil, MD, and Jinny Tavee, MD


FSR Patient Conference - November 2010 - Part 1


Lung Effects from Sarcoidosis

Lung Effects from Sarcoidosis

Reviewed By: Ann Edmundson, April 2006

Credits: This Video is from the WebMD Video Archive.Medical Reference from Medstar Television. www.medstar.comNational Jewish Medical and Research Center,http://www.nationaljewish.orgAmerican Lung Association, http://www.lungusa.org ArthritisFoundation


FSR Patient Conference - November 2010 - Part 2


FSR Patient Conference - November 2010 - Part 3


FSR Patient Conference - November 2010 - Part 4


Neurosarcoidosis


SARCOIDOSIS


Neurosarcoidosis


Neurosarcoidosis 2008 Rare Neuroimmunologic Disorders Symposium, Neurosarcoidosis, Carlos Pardo, MD


Understanding and Diagnosing Sarcoidosis. ClevelandClinic on Oct 6, 2011


"Pathophysiology", Sarcoidosis. Oct 3, 2011


Internal Medicine Grand Rounds: Sarcoidosis


sarcoidosis.avi


Honored Gerry James Lecture: Is sarcoidosis ready for personalized medicine?


WASOGBAL 2011 Panel discussion Health and environment


Sarcoidosis Awareness


WASOGBAL 2011 Maastricht Congress Party


Sarcoidosis: perspective from the 10th WASOG meeting and future plans


Uveitis - Long term concerns


Ophthalmology - Uvea Class5: Panuveitis Part1


The Climb Sarcoidosis Version


What is Sarcoidosis? - Adam Morgenthau, MD, Mt. Sinai Medical Center


Is exercise good for my sarcoidosis?


Will drinking alcoholic beverages


Is fatigue common in Sarcoidosis


Will sarcoidosis affect my pregnancy?


Can my family get sarcoidosis from me?


Is sarcoidosis more prevalent among people of certain occupations?


Is sarcoidosis more common in certain areas in the United States?


Is sarcoidosis a type of cancer?


Could my asthma be sarcoidosis?


If I relocate, will it affect my sarcoidosis?


Information from the Sarcoidosis Seminar


A relative has sarcoidosis. How can I help?


011 Sarcoidosis Patient Conference Q&A#1


Inspirational Stories: Vivian


Prof Marshall at DNA-day 2011 from Tre


Autoimmune and Neurodegenerative Disease


Seminar in Oslo - The Marshall Protocol

                  

Prof Marshall -- Summit on Vitamin D

          

Amy Proal on Viral and Bacterial Metage

           

Amy Proal on Antibodies from Trevor Ma

                         

Prof Trevor Marshall on vitamin D and Ol

           

"Olmesartan is safe and well-tolerated a

  "Olmesartan is safe and well-tolerated at doses from 120-240mg/day"by Greg Blaney 

Sarcoidosis Health Byte


What is sarcoidosis?

To help differentiate between (TB) and (Sacoidosis) we should know that TB causes "caseating granuloma" but Sarcoidosis causes "NON-caseating granulomas" which means there is NO "necrosis" in the center of the granulmoa but in the case of TB there is necrosis in the center of granuloma.

Sarcoidosis


How Microbes feed Chronic Disease

Prof Trevor Marshall - How Microbes feed Chronic Disease from Trevor Marshall on Vimeo.

Prof. Trevor Marshall addressed the issue of biological complexity in his presentation at the 5th Asian Congress on Autoimmunity, in Singapore, on 19 November 2011.

He explored how the Human Microbiome leads to a semi-infinite Interactome, and how the combined metagenomes from the microbes living in and on the human body accumulate to cause chronic disease, including Autoimmune Disease.

Psychiatric and Neurologic comorbidities

Psychiatric and Neurologic comorbidities as systemic dysfunctions from Trevor Marshall on Vimeo.

Highlights from the presentation of Dr Roswitha Goetze-Pelka at the 2011 Autoimmunity Congress Asia. She discusses the new data supporting Plato's observation that "the greatest mistake in the treatment of diseases is that there are physicians for the body, and physicians for the soul, although the two cannot be separated."

Life and Breath Foundation and Sarcoidosis


Sarcoidosis Public Annoncement



Living With and Managing Sarcoidosis


Sarcoidosis Awareness


Ariel talks on Sarcoidosis - Part 1


Ariel talks on Sarcoidosis - Part 2


The Hardest Parts About Sarcoidosis


Sarcoidosis - S.O.A.R.


Al McKay and The All Stars....A Song For Life For Sarcoidosis Foundation


Check Presentation to Sarcoidosis Center


Life and Breath Foundation Video


A Will To Live



Chest x-ray - interpretation - Sarcoidosis


Chronic Diseases: Who's killing us, and how?

MICROBIOLOGIST GARTH NICOLSON interview, (Sudbury, Ontario Aug. 30, 2008). Will YOUR doctor tell you about weaponized mycoplasma? About engineered mycoplasma pathogens in vaccines? Or will he or she treat your symptoms, hook you up for life (or death) on high-priced (and often dangerous) drugs? What's the real story of Chronic Fatigue Syndrome, Gulf War Syndrome, AIDS and other degenerative diseases such as Alzheimer's, Crohns, Parkinson's, Huntington's, Lupus, Lyme disease, fibromyalgia, rheumatoid arthritis, multiple sclerosis, diabetes (type one) and MANY others? If your doctor doesn't know about (or isn't CURIOUS about) US chemical & biological warfare, Operation Paperclip, MKNAOMI, MKDELTA, Texas prison inmates being used as guinea pigs to test genetically engineered pathogens (mycoplasma fermentans incognitus), then get another doctor. You can't afford not to know what Dr. Nicolson is carefully, cautiously, telling us. Nicolson was a speaker at the 9th Common Cause Medical Research Foundation Conference, Sudbury Canada (Aug 29-31, 2008). GARTH NICOLSON is a whistle-blower. The kind that movies won't be made about because the conspiracy is huge, on-going, and reaches to the top. It reveals a key element (a silent weapon) in the quiet war on the 'lower orders.' But SURELY parents (and grandparents) want to know - for starters - what's going on with vaccines their children are forced to take by the Benevolent Homeland. This video is subtitled, 'Who's killing us, and how?' The title avoids the question,'why?' Garth Nicolson, PhD, avers it's for money, greed. Surely, that's a big part of it. Dr. Nicolson is the President, Chief Scientific Officer and Research Professor at the Institute for Molecular Medicine in Huntington Beach, California. Born in 1943 in Los Angeles, Dr. Nicolson received his B.S. in Chemistry from University of California at Los Angeles in 1965 and his Ph.D. in Biochemistry and Cell Biology from the University of California at San Diego in 1970. He is currently Professor of Integrative Medicine at Capitol University of Integrative Medicine and a Conjoint Professor at the University of Newcastle (Australia). He was formally the David Bruton Jr. Chair in Cancer Research and Professor and Chairman of the Department of Tumor Biology at the University of Texas M. D. Anderson Cancer Center in Houston, and he was Professor of Internal Medicine and Professor of Pathology and Laboratory Medicine at the University of Texas Medical School at Houston. He was also Professor of Comparative Pathology at Texas A & M University. Among the most cited scientists in the world, Professor Nicolson has published over 550 medical and scientific papers (including 3 Current Contents Citation Classics), edited 14 books, served on the Editorial Boards of 20 medical and scientific journals and is currently serving as Editor of two (Clinical & Experimental Metastasis and the Journal of Cellular Biochemistry). Professor Nicolson has received peer-reviewed research grants from the U. S. Army, National Cancer Institute, National Institutes of Health, American Cancer Society and the National Foundation for Cancer Research. Dr. Garth Nicolson has won many awards, such as the Burroughs Wellcome Medal of the Royal Society of Medicine (United Kingdom), Stephen Paget Award of the Metastasis Research Society, the U. S. National Cancer Institute Outstanding Investigator Award, and the Innovative Medicine Award of Canada. He is also a Colonel (Honorary) of the U. S. Army Special Forces and a U. S. Navy SEAL (Honorary) for his work on Armed Forces and veterans illnesses. For interview transcript, see snowshoefilms website. See also Dr. Nicolson's book, Project Day Lily and William L.C.Scott and Donald W.Scott's magnificent book, AIDS: The Crime Beyond Belief. yoryevrah



                                       sarcoidosis

                                                                               More PowerPoint presentations from deepak talreja



 
 

Lecture 2 - Eye Anatomy from Root Atlas on Vimeo.

'MP Study Results,' Cpt. Tom Perez's Porto Presentation from Trevor Marshall on Vimeo.

Books on Sarcoidosis



Model Patient: My Life As an Incurable Wise-Ass

 By Karen Duffy





















Endobronchial Ultrasound: An Atlas and Practical Guide

 




Supercalifragilistic-sarcoidiosus.

Even though the sound of it is something quite atrosious. 

If you say it loud enough you'll always sounds sardoshus. 

Supercalifragilistic-sarcoidiosus. 

um-diddle-diddle-um-diddle-eye. um-diddle-diddle-um-diddle-eye.

um-diddle-diddle-um-diddle-eye um-diddle-diddle-um-diddle-eye

Simply Trisha
























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