Through this store we hope to raise funds
to progress awareness of Sarcoidosis & Lyme DiseaseSee
What Goes Wrong?
Macrophages are a type of white blood cell which kill bacterial invaders. Macro-phages are also called phagocytes, or ‘eating cells’. In fact, the word ‘ macro-phage’ means they are the ‘big eaters’.
In Sarcoidosis, macro-phages are highly activated, but not completely effective, so other macro-phages surround and wall off the infected macro-phages (the ones with bacteria inside them), joining together their cell material to form multi-nucleated giant cells with little or no dead material (necrosis) because the bacteria are still alive.
Macrophages must die
Successful macro-phages have to die to kill the engulfed enemy bacteria and complete the phagocytic process. Otherwise, bacteria may be able to live and even replicate safely inside the macro-phage and the human host will still be ill.
This could be disastrous, considering that the life span of a macro-phage may be months or even years. Bacteria can continue living and replicating inside macro-phages within granulomas. Even slowly-reproducing bacteria might establish a stronghold by living inside macro-phages.
Recent research has revealed that sarcoidosis is caused by Th1 inflammation as a result of immune system dysfunction due to a chronic intracellular bacterial infection.
Diagnosis rarely occurs early in the disease process and many symptoms are attributed to other causes (e.g., arthritis, fibromyalgia, chronic fatigue syndrome, migraines, etc.).
The failure to recognize the extent of this disease process accounts for the myth of automatic remission:
Vitamin D and Sarcoidosis
One of the most important things for any sarcoidosis patient to learn is about Vitamin D. I have posted a simple explanation below.
History of vitamin D - Vitamin D was misnamed when it was discovered in 1922. It’s not a true vitamin because an ongoing nutrient source is not required to sustain normal levels in the body. Vitamin D is properly classified as a secosteroid hormone precursor. A hormone is a chemical substance produced by one organ and then transported in the bloodstream to a target organ, where it causes a specific biological action.
This animated video focuses on emerging research around the importance of vitamin D's connection to a range of vital systems in the human body.
Vitamin D has several metabolites (forms). For practical purposes, this explanation is limited to two metabolites: 25-D (inactive) and 1,25-D (active).
25-D (also known as calciferol, calcidiol, 25-hydroxycholecalciferol or 25-hydroxyvitamin-D) has a less active role in vitamin D metabolism than the more active 1,25-D but it does increase calcium absorption from the gut and, theoretically, acts (at high levels) as an antagonist on the Vitamin D Receptor. 25-D is produced in the liver and synthesized in the cells of the skin in reaction to sunlight. 25-D may also be obtained from naturally occurring dietary sources (especially fish, fish oils, liver, eggs), processed foods that are supplemented with vitamin D (dairy products, cereals, etc.) and vitamin supplements.
25-D is the major circulating form of vitamin D. It is used in the production of (1,25-D) in the kidneys.
D3 is the form of 25-D that comes from animals. it is also produced in the skin and is available in pill or capsule form.
1,25-D (also known as calcitriol or 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin-D3) is a potent secosteroid paracrine mediator and affects almost all cellular activity.
1,25-D is formed in the kidneys, the skin and many other tissues of the body. In addition, light falling in the eyes may cause generation of 1,25-D.
Testing your Vitamin D Levels
To verify inflammatory illness/Sarcoidosis and dysregulated vitamin D metabolism, we recommend measuring two D-metabolites:
25-hydroxyvitamin-D (25D or D2/D3).
Other Links Below:
Links from Chronic Illness RecoveryPatient Handouts Sourced from Medline Plus
MedlinePlus presents interactive health tutorials from the Patient Education Institute. Learn about the symptoms, diagnosis and treatment for a variety of diseases and conditions. Also learn about surgeries, prevention and wellness. Each tutorial includes animated graphics, audio and easy-to-read language.
Medline Plus - Articles about Sarcoidosis
ABSTRACT - The synthesis of vitamin D is altered by the granulomatous inflammation of sarcoidosis leading to increased production of 1, 25-dihydroxyvitamin D. Mounting evidence suggests that vitamin D is an immunomodulating hormone that inhibits both antigen presentation by cells of the innate immune system, and the cytokine release and proliferation of Th1 cells. These and other extraskeletal health benefits have led to an increase in vitamin D assessment and pharmacological supplementation in the general population. This review highlights the altered synthesis and general immunomodulating properties of vitamin D with a special emphasis on known interactions with sarcoidosis. In addition, the assessment of vitamin D nutritional status, its pharmacological supplementation, and the management of bone health in patients with sarcoidosis are reviewed.KEYWORDS: Sarcoidosis, vitamin D, 1, 25-dihydroxyvitamin D
Our body's immune system is supposed to protect us from infection and disease, but there is a condition called "sarcoidosis" that actually causes a person's immune system to damage its own tissues.
In this "Faces of Rare Disease," Sabrina Sonnier talks about this diagnosis that could threaten every organ in her body.
Reviewed By: Ann Edmundson, April 2006
Credits: This Video is from the WebMD Video Archive.Medical Reference from Medstar Television. www.medstar.comNational Jewish Medical and Research Center,http://www.nationaljewish.orgAmerican Lung Association, http://www.lungusa.org ArthritisFoundation
To help differentiate between (TB) and (Sacoidosis) we should know that TB causes "caseating granuloma" but Sarcoidosis causes "NON-caseating granulomas" which means there is NO "necrosis" in the center of the granulmoa but in the case of TB there is necrosis in the center of granuloma.
Prof. Trevor Marshall addressed the issue of biological complexity in his presentation at the 5th Asian Congress on Autoimmunity, in Singapore, on 19 November 2011.
Highlights from the presentation of Dr Roswitha Goetze-Pelka at the 2011 Autoimmunity Congress Asia. She discusses the new data supporting Plato's observation that "the greatest mistake in the treatment of diseases is that there are physicians for the body, and physicians for the soul, although the two cannot be separated."
CORPUS CHRISTI (Kiii News) – Dr. Gregg Silverman joins John Thomas on Monday's 3 News First Edition to discuss an disease that causes swelling in the lungs, liver, eyes, and other tissues. Sarcoidosis is a chronic inflammatory disease affecting organs and other tissues throughout the body. It can also affect several parts of the body with arthritis and skin lesions. Dr. Silverman talks about what this condition is and what we can do to spot the signs and symptoms of the disease.
MICROBIOLOGIST GARTH NICOLSON interview, (Sudbury, Ontario Aug. 30, 2008). Will YOUR doctor tell you about weaponized mycoplasma? About engineered mycoplasma pathogens in vaccines? Or will he or she treat your symptoms, hook you up for life (or death) on high-priced (and often dangerous) drugs? What's the real story of Chronic Fatigue Syndrome, Gulf War Syndrome, AIDS and other degenerative diseases such as Alzheimer's, Crohns, Parkinson's, Huntington's, Lupus, Lyme disease, fibromyalgia, rheumatoid arthritis, multiple sclerosis, diabetes (type one) and MANY others? If your doctor doesn't know about (or isn't CURIOUS about) US chemical & biological warfare, Operation Paperclip, MKNAOMI, MKDELTA, Texas prison inmates being used as guinea pigs to test genetically engineered pathogens (mycoplasma fermentans incognitus), then get another doctor. You can't afford not to know what Dr. Nicolson is carefully, cautiously, telling us. Nicolson was a speaker at the 9th Common Cause Medical Research Foundation Conference, Sudbury Canada (Aug 29-31, 2008). GARTH NICOLSON is a whistle-blower. The kind that movies won't be made about because the conspiracy is huge, on-going, and reaches to the top. It reveals a key element (a silent weapon) in the quiet war on the 'lower orders.' But SURELY parents (and grandparents) want to know - for starters - what's going on with vaccines their children are forced to take by the Benevolent Homeland. This video is subtitled, 'Who's killing us, and how?' The title avoids the question,'why?' Garth Nicolson, PhD, avers it's for money, greed. Surely, that's a big part of it. Dr. Nicolson is the President, Chief Scientific Officer and Research Professor at the Institute for Molecular Medicine in Huntington Beach, California. Born in 1943 in Los Angeles, Dr. Nicolson received his B.S. in Chemistry from University of California at Los Angeles in 1965 and his Ph.D. in Biochemistry and Cell Biology from the University of California at San Diego in 1970. He is currently Professor of Integrative Medicine at Capitol University of Integrative Medicine and a Conjoint Professor at the University of Newcastle (Australia). He was formally the David Bruton Jr. Chair in Cancer Research and Professor and Chairman of the Department of Tumor Biology at the University of Texas M. D. Anderson Cancer Center in Houston, and he was Professor of Internal Medicine and Professor of Pathology and Laboratory Medicine at the University of Texas Medical School at Houston. He was also Professor of Comparative Pathology at Texas A & M University. Among the most cited scientists in the world, Professor Nicolson has published over 550 medical and scientific papers (including 3 Current Contents Citation Classics), edited 14 books, served on the Editorial Boards of 20 medical and scientific journals and is currently serving as Editor of two (Clinical & Experimental Metastasis and the Journal of Cellular Biochemistry). Professor Nicolson has received peer-reviewed research grants from the U. S. Army, National Cancer Institute, National Institutes of Health, American Cancer Society and the National Foundation for Cancer Research. Dr. Garth Nicolson has won many awards, such as the Burroughs Wellcome Medal of the Royal Society of Medicine (United Kingdom), Stephen Paget Award of the Metastasis Research Society, the U. S. National Cancer Institute Outstanding Investigator Award, and the Innovative Medicine Award of Canada. He is also a Colonel (Honorary) of the U. S. Army Special Forces and a U. S. Navy SEAL (Honorary) for his work on Armed Forces and veterans illnesses. For interview transcript, see snowshoefilms website. See also Dr. Nicolson's book, Project Day Lily and William L.C.Scott and Donald W.Scott's magnificent book, AIDS: The Crime Beyond Belief. yoryevrah
Books on Sarcoidosis
Primary care medicine: office evaluation and management of the adult patient (Chapter 51) By Allan H. Goroll, Albert G. Mulley
Gulf War and Health: Fuels, combustion, products, and propellants By Carolyn Fulco, Catharyn T. Liverman, Institute of Medicine (U.S.). Committee on Health Effects Associated with Exposures during the Gulf War
Even though the sound of it is something quite atrosious.
If you say it loud enough you'll always sounds sardoshus.