Tadayoshi Miyamoto, Ph.D.

Morinomiya University of Medical Sciences

1-26-16 Nankokita Suminoe-ku,

Osaka City, Osaka 559-8611, JAPAN

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Exercise Physiology

Cardio-Respiratory  Control Lab.


Tadayoshi Miyamoto, Ph. D.

Year of Birth 1967
Position Professor Degree Ph.D.


B. Ed., Dept. of Education, Osaka Kyoiku Unv.
M. Ed. Grad. Sch. of OsakaKyoiku Univ., 
Ph.D. Grad. Sch. of Osaka City Univ., 
Research Fellow, Osaka City Univ., 

Employment History:
Research Associate, School of Health and Sports Sci./Div. of Motor Behavioral Ed, 
Osaka University

Research Fellow, Dept. of Cardiovascular Dynamics, 
National Cardiovascular Research Institute
Professor, Faculty of Health Sciences, 
Morinomiya University of Medical Sciences
Professor, Graduate School of Health Sciences, 
Morinomiya University of Medical Sciences

Courses and/or Classes Taugh
Fields of Specialization Exercise Physiology

Research Topics
Cardio-respiratory control during exercise

Research Keywords
Respiratory control
Circulatory control
Exercise Physiology
System analysis
Central blood volume

Menbership in Academic Societies


Development of a Quantitative Examination for Respiratory Regulation

In patients with heart failure, abnormal ventilatory patterns such as an enhanced ventilatory response to exercise happen occasionally. The respiratory regulation is performed by sensing the concentration of CO2 in arterial blood (PaCO2) and/or pH. Because the unnecessarily augmented breathing is considered to relate to the abnormal respiratory regulation in patients with heart failure, a quantitative examination method for abnormal respiratory regulation should be developed.

In normal subjects, we first measured the increment of respiration in response to the increase in PaCO2 achieved by an inspiration of high CO2 content gas. Next, we measured the decrease in PaCO2 by hyperventilation. The two data sets were combined in a equilibrium diagram of the respiratory regulation. This method will be improved and simplified to examine the respiratory regulation in patients with heart failure.



Analysis of Breath-by-Breath Gas Exchange in Small Animal.

    Beginning in 2009, we developed a  based system of small animal experiment to perform breath-by-breath analysis of ventilation and respiratory gas exchange in rat. 

Aerobic Interval Exercise Training Attenuates the Respiratory Drive during Exercise through Desensitization of the Respiratory Central Controller

Tadayoshi Miyamoto, Hidehiro Nakahara

Faculty of Health Sciences, Morinomiya University of Medical Sciences


Aerobic interval training(AIT) is more effective than continuous training in enhancing cardio-respiratory function and symptom severity in chronic heart failure(CHF). We examined how AIT affects ventilatory regulation. In 7 healthy subjects, at rest and during exercise at low and high intensities, we separately characterized respiratory central controller and peripheral plant (subsytems) of chemoreflex by changing inspiratory CO2 fraction and by making subjects alter ventilation (VE), respectively. RESULTS: AIT did not affect both subsystems at rest and during light intensity exercise. During high intensity exercise, rightward shift of central controller characteristics mainly attributed to lower VE (-9.4%,p<0.01) and higher end tidal PCO2 (+4.4%,p<0.05) after AIT. A attenuates the respiratory drive during heavy exercise through desensitization of the respiratory central controller. Such mechanism may contribute to favourable effects of AIT in CHF.