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Publications

New paper titled "Comprehensive DNA methylation study identifies novel progression - related and prognostic markers for cutaneous melanoma"  has been published by SYS-MEL partners in KUL, UCD and OncoMark in BMC Medicine in June 2017. This study identified novel markers of melanoma tumour development and progression. 



Review article titled "Master Transcriptional Regulators in Cancer; Discovery via Reverse Engineering Approaches and Subsequent Validation" has been published in Cancer Research in May 2017. 

Paper titled "Examining the In-Vitro Efficacy of the IAP Antagonist Birinapant as a Single-Agent or in Combination with Dacarbazine to Induce Melanoma Cell Death" has accepted for publication in Oncology Research in March 2017.


Paper titled "Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozomide" has been published in Oncotarget in September 2016. 


Review article titled "Prognostic and predictive biomarkers in melanoma: an update" has been published in Expert Review of Molecular Diagnostics in February 2016.


Paper titled "An Analysis of the Truncated Bid- and ROS dependent Spatial Propagation of Mitochondrial Permeabilization Waves during Apoptosis has been published in the Journal of Biological Chemistry in February 2016. 


Protocol titled "Measuring Caspase Activity by Forster Resonance Energy Transfer" has been published in the Cold Spring Harbor Protocols in January 2015. 

Paper titled "A systems biological analysis of apoptosome formation and apoptosis execution supports allosteric procaspase‑9 activation" has been published by RCSI partners in Journal of Biological Chemistry in September 2014. It describes the findings regarding dogma that all initiator procaspases require homodimerization for activation during apoptosome formation.

Review article titled "Key regulators of apoptosis execution as biomarker candidates in melanoma" has been published in Molecular and Cellular Oncology in September 2014
Paper titled " Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways" has been published by RCSI partners in Cell Death & Disease in January 2014. It discusses the influence of autophagic and proteasomal activity on apoptosis susceptibility, which is now rapidly gaining more attention as a significant modulator of cell death signalling in the context of human health and disease, such as melanoma.



Review article titled: "Epigenetics of malignant melanoma" has been published in Seminars in Cancer Biology in October 2017 [Epub ahead of print]


Review article titled: "Epidemiologic design and analysis for proteomic studies: a primer on -omic technologies" has been published in the American Journal of Epidemiology in March 2015.