The laboratory of Biophotonics imaging and sensingResearch Focus
Our lab is located at Faculty Memorial Hall 009, NJIT, University Heights, Newark, NJ, 07102. We have spectral domain and swept source optical coherence tomography (OCT) systems with graphic processing units assisted real-time image processing capability. We also have a state-of-art facility for the fabrication of fiber-optic instruments.
Quantitative Optical Coherence Elastography (qOCE)
We developed and validated a novel optical coherence elastography technology to achieve quantitative mechanical characterization of biological tissue. The miniature qOCE device can perform characterization on time dependent and spatial dependent tissue dynamics. A wide range of mechanical properties (Young's modulus, creep function, relaxation function, etc) can be obtained using our device from biological tissue in vivo.
OCT based microangiography
We are able to provide high sensitivity micro vasculature detection and visualization using interframe variation of OCT signal. We can also assess blood flow quantitatively using optical Doppler tomography. Our capability in blood vessel imaging can be used to study many important biological processes, such as cancer angiogenesis, wound healing, and brain injury.
Optical image processing
Novel image processing algorithms are being investigated. For example, we have studied the entropy of OCT image as a feature related to the pathological status of tissue. We have also developed various wavelet domain image denoise methods. Our goal is to improve the quality of OCT image through post processing and extract image features that are directly related to the physiological and pathological status of tissue.