Our laboratory studies the immune response to infectious diseases, with a primary focus on the factors associated with initial innate recognition of the pathogen. The innate immune system is an evolutionarily conserved aspect of immunity. How the innate immune system recognizes and responds to infection can have profound affects on the adaptive response and ultimately the fate of the host. Understanding how stimulation of the innate immune system leads to different clinical outcomes is critical to understanding the genetic basis of disease resistance. As part of this work, we use different in vitro and in vivo models to identify common responses across different host species. Understanding how different species detect and respond to infection allows for the development of therapies which will work against large classes of pathogens and for a wide variety of animal species.
Given the diversity of the host models used, a large aspect of our research involves identifying and characterizing the host response genes.
Selected PublicationsP. K. Nighot, A. Moeser, R. A. Ali, A. T. Blikslager, and M. D. Koci. Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanged expression. Virology. 401:146-54, 2010.
E. Strain, L. A. Kelley, S. Schultz-Cherry, S. V. Muse, and M. D. Koci. Genomic Analysis of Closely Related Astroviruses. Journal of Virology. 82: 5099-5103, 2008.
M. D. Koci, L. A. Kelley, D. L. Larsen, and S. Schultz-Cherry. Astrovirus-induced synthesis of nitric oxide contributes to virus control during infection. Journal of Virology. 78:1564-1574, 2004.
M. D. Koci, L. A. Moser, L. A. Kelley, D. L. Larsen, C. C. Brown, and S. Schultz-Cherry. Astrovirus induces diarrhea in the absence of inflammation and cell death. Journal of Virology. 77:11798-11808, 2003.
(Assistant Professor, Viral Immunology)
KOCI LAB TOOLS