In addition to be being a primary site for colonization and entry of pathogens to the body, mucosal surfaces are one of the most metabolically and physiologically active regions of any animal. Specifically, the mucosal surface of the gastrointestinal tract contains a complex network of highly specialized cells involved in digestion, nutrient absorption, immune response, hormone regulation, and neurotransmission. In addition to the host cells, the intestinal surface is also populated a complex mixture of commensal microorganisms. Understanding how all these cells work in concert is essential to our understanding how the overall health of any animal is maintained. Our laboratory is currently working to understand how changes in the intestinal microflora affect the expression and function of the different host cell found in the gut, and how these changes impact the overall health and fitness of whole animal.
M. Chichlowski, J. Croom, R. Qui, B. W. McBride and M. D. Koci. Direct Fed Microbial, Primalac®, Supplementation and Jejunal Glucose and Proline Transport in Broiler Chickens. International Journal of Poultry Science. 7: 1163-1166, 2008.
M. Chichlowski, J. Croom, B. W. McBride, L. R. Daniel, G. Davis and M. D. Koci. Direct-fed microbial and salinomycin modulate whole body and intestinal oxygen consumption and intestinal mucosal cytokine production in the broiler chick. Poultry Science. 86:1100-1106, 2007.
M. Chichlowski, J. Croom, F. Edens, B. W. McBride, R. Qiu, C. C. Chiang, L. R. Daniel, G. W. Havenstein and M. D. Koci. Microarchitecture and spatial relationship between bacteria and ileal, cecal and colonic epithelium in chicks fed a direct-fed microbial and salinomycin. Poultry Science. 86:1121-1132, 2007.
KOCI LAB TOOLS