Recent advances in free-electron laser technology have demonstrated the ability to collect millions of "snap-shot" hard X-ray diffraction patterns from single bio-particles (e.g. viruses, cells) or hydrated protein nanocrystals. Other modes, such as Laue diffraction, fast (correlation) SAXS, and pump-probe experiments aimed at observing protein dynamics are also under development*.
The aim of this small workshop is to determine what opportunities the invention of the FEL offers to biologists.
For a brief review, see Chapman, Nature Materials, 8, 299 (2009)
Register online at http://www.regonline.com/FELS2011
M. Rossman (Purdue), D. Reese (Caltec), Louise Johnson (Oxford), K. Moffat (Chicago), Jack Johnson (Scripps), Bill Cramer (Purdue), K. Hodgson (SLAC), I. Schlichting (MPI Heidelburg), R. Neutze (Gothenburg), G. Simpson (Purdue), P. Fromme (ASU), H. Chapman (DESY), M. Frank (LLNL), Adam Arkin (UCB), R.M. Stroud (UCSF), A. Brunger (Stanford), G. Phillips (Wisc), S. Lane (CBST), C. Betzel (U.Hamburg), M.Wilmanns (EMBL), K. Nugent (CXS), J.C.H.Spence (ASU/LBL)
Tentative plans include talks on the following topics: The current status; Single Particles; Protein Nanocrystals; Dynamics - pump-probe possibilities; The phase problem; Instrumentation - (Sources, Detectors; Injection devices), In-situ experiments, Fast ab-initio fluctuation SAXS, In-jet snap-shot chemistry, Alternative methods - imaging in biology reviewed.
Inquires to J.C.H. Spence at email@example.com.
Funded by contributions from LBNL, CBST, LLNL, ASU, NSF, and SSRL SMB Program.
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