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Early Infection and Re-infection in Women Exposed Mucosally to HIV-1

Funding: NIH/NIAID R37 AI038518 
PI: J Overbaugh
Time period: 09/15/95 – 02/28/15

The proposed research aims (1) to further define the relationship of viral complexity and viral subtype with systemic and mucosal viral burden and disease progression; (2) to determine if intersubtype recombinants are becoming more prevelant; (3) to determine if there are differences in neutralizing antibody responses in women who are initially infected with multiple variants versus a single variant; and (4) to examine the role of endogenous and exogenous female hormones in HIV shedding and pathogenesis during chronic disease