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Antiretroviral Therapy and HIV-1 Infectivity in Women

Funding: R56 AI058698 NIH/NIAID
PI: RS McClelland
Time Period: 08/10/11 – 07/31/13

The proposed research aims (1) to develop and validate predictive models for genital shedding of HIV-1 RNA with genotypic resistance in an ongoing prospective cohort study of Kenyan women on 1st line ART; (2) to conduct a multidisciplinary study to identify and understand changes in sexual risk behavior over the course of long-term ART; and (3) to identify periods of elevated risk  for HIV-1 transmission by examining the association between ART adherence and sexual risk behavior in high-risk Kenyan women.