Anindya Roy Lab

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                              Dr. Anindya Roy









                             Associate Professor  
                             Dept. of Biotechnology 
                             IIT Hyderabad
                             Kandi, Sangareddy 502285
                             Telangana, INDIA  

                              E-Mail: anindya@iith.ac.in
                              Scopus Author ID: 22953034800

                                                                      
 
Research area: DNA repair, cancer


Research Overview: My laboratory studies DNA repair. Nucleotide modification plays a critical role in many biological processes directly associated with cancer. Presently we are focusing on the DNA repair reaction targeted to alkylated DNA in relation to cancer. We use biochemical, molecular and genetic approach and exploit budding yeast as well as mammalian cell culture systems. We also translate research outputs and develop clinical diagnostic reagents and tools aiming at the early detection of cancer.    


                                                              Current Lab members (PhD students)

                                                                
        

            









                   
          
           
   






                                                   Nikhil Tuti                     B. Raghunath                       Deepa Akula

 

       Recent Publications from the lab Lab


[1] F.A. Khan, S. Ahmad, N. Kodipelli, G. Shivange, R. Anindya*, Syntheses of a library of molecules on the marine natural product ianthelliformisamines platform and their biological evaluation, Org Biomol Chem 12(23) (2014) 3847-65.

[2] G. Shivange, N. Kodipelli, R. Anindya*, A nonradioactive restriction enzyme-mediated assay to detect DNA repair by Fe(II)/2-oxoglutarate-dependent dioxygenase, Anal Biochem 465 (2014) 35-7.

[3] G. Shivange, N. Kodipelli, M. Monisha, R. Anindya*, A role for Saccharomyces cerevisiae Tpa1 protein in direct alkylation repair, J Biol Chem 289(52) (2014) 35939-52.

[4] S. Agarwal, P. Mishra, G. Shivange, N. Kodipelli, M. Moros, J.M. de la Fuente, R. Anindya*, Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1, Analyst 140(4) (2015) 1166-73.

[5] G. Shivange, N. Kodipelli, R. Anindya*, 2-Hydrazinobenzothiazole-based etheno-adduct repair protocol (HERP): a method for quantitative determination of direct repair of etheno-bases, DNA Repair (Amst) 28 (2015) 8-13.

[6] V. Singh, M. Monisha, R. Anindya, P. Das, Self assembled nanocages from DNA–protoporphyrin hybrid molecules, RSC Advance 5(108) (2015) 89025-89029.

[7] R. Kumari, S. Singh, M. Monisha, S. Bhowmick, R. Anindya, N. Das, P. Das, Hierarchical coassembly of DNA-triptycene hybrid molecular building blocks and zinc protoporphyrin IX, Beilstein J Nanotechnol 7 (2016) 697-707.

[8] G. Shivange, M. Monisha, R. Nigam, N. Kodipelli, R. Anindya*, RecA stimulates AlkB-mediated direct repair of DNA adducts, Nucleic Acids Res 44(18) (2016) 8754-8763.

[9] R. Anindya*, Non-heme dioxygenases in tumor hypoxia: They're all bound with the same fate, DNA Repair (Amst) 49 (2017) 21-25.

[10] M. Sharma, S.C. Vedithi, M. Das, R. Anindya, M. Ebenezer, Sequence homology and expression profile of genes associated with DNA repair pathways in Mycobacterium leprae, Int J Mycobacteriol 6(4) (2017) 365-378.

[11] A. Deepa, K. Naveena, R. Anindya*, DNA repair activity of Fe(II)/2OG-dependent dioxygenases affected by low iron level in Saccharomyces cerevisiae, FEMS Yeast Res 18(2) (2018).

[12] M. Mohan, V. Pandya, R. Anindya*, Escherichia coli AlkB and single-stranded DNA binding protein SSB interaction explored by Molecular Dynamics Simulation, J Mol Graph Model 84 (2018) 29-35.

[13] R. Nigam, R. Anindya*, Escherichia coli single-stranded DNA binding protein SSB promotes AlkB-mediated DNA dealkylation repair, Biochem Biophys Res Commun 496(2) (2018) 274-279.

[14] R. Nigam, K.R. Babu, T. Ghosh, B. Kumari, D. Akula, S.N. Rath, P. Das, R. Anindya*, F.A. Khan, Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3, Bioorg Med Chem 26(14) (2018) 4100-4112.

[15] R. Nigam, M. Mohan, G. Shivange, P.K. Dewangan, R. Anindya*, Escherichia coli AlkB interacts with single-stranded DNA binding protein SSB by an intrinsically disordered region of SSB, Mol Biol Rep 45(5) (2018) 865-870.

[16] M. Sharma, M. Das, D. Diana, A. Wedderburn, R. Anindya*, Identification of novel open reading frames in the intergenic regions of Mycobacterium leprae genome and detection of transcript by qRT-PCR, Microb Pathog 124 (2018) 316-321.

[17] G.P. Singh, R. Nigam, G.S. Tomar, M. Monisha, S.K. Bhoi, A. S, K. Sengar, D. Akula, P. Panta, R. Anindya*, Early and rapid detection of UCHL1 in the serum of brain-trauma patients: a novel gold nanoparticle-based method for diagnosing the severity of brain injury, Analyst 143(14) (2018) 3366-3373.

[18] G.S. Tomar, G.P. Singh, D. Lahkar, K. Sengar, R. Nigam, M. Mohan, R. Anindya*, New biomarkers in brain trauma, Clin Chim Acta 487 (2018) 325-329.

[19] Sharma M, Akula D, Mohan M, Nigam R, Das M, Anindya R. Heteroexpression of Mycobacterium leprae hypothetical protein ML0190 provides protection against DNA-alkylating agent methyl methanesulfonate. Biochem Biophys Res Commun. 509(3) (2018) 779-783.

[20] Mohan M, Akula D, Dhillon A, Goyal A, Anindya R, Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase (2019) Nucleic Acids Res. 47(22):11729-11745.