Debasis Dash, Ph.D

Research Interests

I am interested in developing computational tools and software for high-throughput biological data (NGS, Mass-spectrometry) analysis and using computational approaches for understanding protein function. My interests include:
  • Algorithms and software development for mass-spectrometry based proteomics and proteogenomics analysis
  • Comparative Genomics 
  • Machine learning for proteins 
  • Elucidating the role of intrinsic disorder in tuberculosis drug targets and the transcription network of yeast

  • Development of Polymorphism Markup Language

I have been involved in the development of different software tools for functional genomics and genome data mining. This includes software like PLHost for identification of invariant peptides as signatures of specific functional family and GeneDecipher for identification of protein coding genes in the genome. I am also part of an international effort for interoperability of biological data among various databases as well as in developing a genotype to phenotype database.

Office:
Room No. 301,
CSIR-IGIB,
Sukhdev Vihar, Mathura Road,
New Delhi - 110 020
Tel: 91-11-29879 301
Fax: +91 011 27667 471
e-mail: ddash@igib.in

 

Patents

  • A computer based method for identifying peptides useful as drug targets.
          US, PCT: NF64/2000; Samir K. Brahmachari and Debasis Dash
  • A computer based method for predicting protein coding DNA sequences useful as drug targets. 
           US, PCT: NF 421/03; S.K. Brahmachari, D. Dash, J.K Maheshwari and R. Sharma
     

Awards and Achievements


  • The CSIR Young Scientist Award for the year 2004 in Biological sciences for use of short peptide stretches to relate proteins in different genomes, which have similar function, and also for development of PLHOST software and associated databases
 

Publications


2015

  • Probing the missing human proteome: A computational perspective

  • Kumar D, Jain A and Dash D
    J. Proteome Res. 2015. (Accepted)

  • Expression profiling of lymph nodes in tuberculosis patients reveal inflammatory milieu at site of infection

  • Abhijit Maji, Richa Misra, Anupam Mondal, Dhirendra Kumar, Divya Bajaj, Anshika Singhal, Gunjan Arora, Asani Bhaduri, Andaleeb Sajid,
    Sugandha Bhatia, Sompal Singh, Harshvardhan Singh, Vivek Rao, Debasis Dash, Baby Shalini E, Joy Sarojini Michael, Anil Chaudhary, 
    Rajesh Gokhale, and Yogendra Singh
    Sci Rep. 2015. (Accepted)

  • Transcriptome and venom proteome of the box jellyfish Chironex fleckeri.

  • Brinkman DL, Jia X, Potriquet J, Kumar D, Dash D, Kvaskoff D, Mulvenna J.
    BMC Genomics. 2015 May 27

2014

           Kumar D, Mondal AK, Yadav AK , Dash D.
           Proteomics. 26 Aug 2014           Kaurani L, Vishal M, Kumar D, Sharma A, Mehani B, Sharma C, Chakraborty S, Jha P, Ray J, Sen A, Dash D, Ray K, Mukhopadhyay A.
           Invest Ophthalmol Vis Sci. 2014 Apr 24         R Das Roy, D Dash
         Amino Acids

2013

          Upadhyay RD, Yadav AK, Sonawane S, Goankar R, Dash D and Balasinor NH

          J Anal Bioanal Tech. Sep 16 2013 

          Faruq M, Narang A, Kumari R, Pandey R, Garg A, Behari M, Dash D, Srivastava A, Mukerji M

          Clin Genet. Sep 16 2013.

            Yadav AK, Kadimi PK, Kumar D and Dash D
            Bioinformatics. 20 Aug 2013
            Kumar D, Yadav AK, Kadimi PK, Nagaraj SH, Grimmond SM, Dash D
            Mol Cell Proteomics. 2013 Jul 23.
           GP Singh, D Dash
           PLoS one 8 (5), e64893

          Sinha A, Yadav AK, Chakraborty S, Kabra SK, Lodha R, Kumar M, Kulshreshtha A, Sethi T, Pandey R, Malik G, Laddha S, 
          Mukhopadhyay A, Dash D, Ghosh B,Agrawal A.
          The Journal of allergy and clinical immunology,10.1016/j.jaci.2013.03.035.

2012

           AK Yadav, D Kumar, D Dash
           PLoS one 7 (11), e50651
  • Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis.
            Vashisht R, Mondal AK, Jain A, Shah A, Vishnoi P, Priyadarshini P, Bhattacharyya K, Rohira H, Bhat AG, Passi A,   
            Mukherjee K, Choudhary KS, Kumar V, Arora A, Munusamy P, Subramanian A, Venkatachalam A, Gayathri S, Raj S, 
            Chitra V, Verma K, Zaheer S, Balaganesh J, Gurusamy M, Razeeth M, Raja I, Thandapani M, Mevada V, Soni R, Rana
            S, Ramanna GM, Raghavan S, Subramanya SN, Kholia T, Patel R, Bhavnani V, Chiranjeevi L, Sengupta S, Singh PK,
            Atray N, Gandhi S, Avasthi TS, Nisthar S, Anurag M, Sharma P, Hasija Y, Dash D, Sharma A, Scaria V, Thomas Z;     
            OSDD Consortium, Chandra N, Brahmachari SK, Bhardwaj A 
            PLoS One. 2012; 7(7):e39808. Epub 2012 Jul 11
  • Knowledge engineering for health: a new discipline required to bridge the "ICT gap" between research and healthcare.
            Beck T, Gollapudi S, Brunak S, Graf N, Lemke HU, Dash D, Buchan I, Díaz C,Sanz F, Brookes AJ.

            Hum Mutat. 2012 May;33(5):797-802
  • Location of disorder in coiled coil proteins is influenced by its biological role and subcellular localization: a GO-based study on human proteome.
            Anurag M, Singh GP, Dash D.

            Mol Biosyst. 2012 Jan;8(1):346-52.

2011




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