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Mitochondrial Rescue


The mitochondria are organelles within the cells that produce energy for the body. They also play a part in the function of the immune system, providing a defence against invaders separate to the white blood cells. When mitochondria become weakened, the whole body suffers. There are ways of testing the function of mitochondrial function to find out whether they are part of the cause of disease.

Polymorphisms (SNPs) and poisoning can disorder mitochondrial function by inhibition of the respiratory chain and uncoupling the oxidative phosphorylation process. Some poison inhibitors include barbiturates, rotenone, sulphuric acid, carbon monoxide, cyanide and some antibiotics (Oligomycin, Piericidin-A). Some ATP-ase uncoupling poisons are 2-4-dinitrophenol,dinitrocresol,pentachlorophenol. Evaluation of cytochrome C oxidase, NADH-ubiquinone oxidoreductase and mitochondrial ATP synthase are SNPs under current scientific investigation.

Specific antioxidants and oral and injection supplements specific to patients with genomic defects focus on mitochondrial rescue.

References
Liu J, Atamna H, Kuratsune H, Ames BN. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci. 2002 Apr;959:133-66. PMID: 11976193