Recently, the link between progranulin and its vital role in defending against prolonged inflammation was further strengthened when scientists found that progranulin could potentially counteract tumor necrosis factor-alpha (TNF-α), a major pro-inflammatory cytokine that stimulates activation of the inflammatory response (Tang, et al., 2011). Progranulin was found to bind to TNF-α’s receptors, thus probably blocking interaction between TNF-α and its receptors. This could prevent TNF-α from activating the inflammatory response, supporting the idea that progranulin could be essential in preventing chronic inflammation, and insufficient levels of it could lead to diseases like FTD.
We based our idea on this finding, and progranulin was our initial focus.
NF-κB inflammatory pathway