Hypothesis 1 If I covalently attach the delivered drug to the periphery of the Dendrimer forms Dendrimer prodrugs, then the hydrophobic nature of the original drug can be diminished.
Hypothesis 2 If I load the original drug in polymeric micelles, then it can penetrate tissues easier.
Dendrimer is commonly used in the encapsulation of hydrophobic compounds and for the delivery of anticancer drugs. Covalently attaching the delivered drug to the periphery of the Dendrimer forms Dendrimer prodrugs and decreases the hydrophobic nature of the original drug, thus improving the photosensitivity of metal Phthalocyanine compounds. Meanwhile, the use of polymeric micelle may strengthen the targeting of the drug, for the micelle material can self-assemble into core-shell type nano-micelles in water, making the tissues easier to penetrate for the drug. Thus, it is reasonable to hypothesize that, the use of Dendrimer and polymeric micelle can solve the questions mentioned.